White matter alterations in amnestic mild cognitive impairment: a tract-based spatial statistics study

Berrin Çavuşoğlu; Emel Ada; Derya Durusu Emek Savaş; Görsev Yener

Article Details

White matter alterations in amnestic mild cognitive impairment: a tract-based spatial statistics study

Authors:

Berrin Çavuşoğlu | Emel Ada | Derya Durusu Emek Savaş | Görsev Yener

Publisher:

Dokuz Eylul University

Main Topics:

Radyoloji ve Organ Görüntüleme

Journal:

Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi Vol.36 Issue 3, pp.267-274

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001283143

pISSN:

2602-3148

Keywords:

Abstract:

 Purpose: To compare white matter WM structural alterations between the subjects with amnestic mild cognitive impairment MCI which is a transitional state to Alzheimers Disease AD and healthy elderly controls. Methods: Diffusion tensor imaging DTI scans of 20 subjects with amnestic MCI and 20 healthy control groups who are matched by age, gender, and education with the MCI group between 2011 and 2016 were examined by in this retrospective study. WM structural integrity was analyzed using tract based spatial statistics TBSS for voxel-based differences in fractional anisotropy FA between the two groups. Results: Fractional anisotropy was found significantly lower in the forceps minor, the body and genu of the corpus callosum, the right anterior thalamic radiation, the right cingulum, the right inferior fronto-occipital fasciculus, the right superior longitudinal fasciculus, and the right superior corona radiata in the MCI group than the control group. Conclusion: TBSS analysis is a promising method to examine structural WM integrity. These findings suggested that the DTI measurements may be useful for the detection of preclinical changes in AD.

 Purpose: To compare white matter WM structural alterations between the subjects with amnestic mild cognitive impairment MCI which is a transitional state to Alzheimers Disease AD and healthy elderly controls. Methods: Diffusion tensor imaging DTI scans of 20 subjects with amnestic MCI and 20 healthy control groups who are matched by age, gender, and education with the MCI group between 2011 and 2016 were examined by in this retrospective study. WM structural integrity was analyzed using tract based spatial statistics TBSS for voxel-based differences in fractional anisotropy FA between the two groups. Results: Fractional anisotropy was found significantly lower in the forceps minor, the body and genu of the corpus callosum, the right anterior thalamic radiation, the right cingulum, the right inferior fronto-occipital fasciculus, the right superior longitudinal fasciculus, and the right superior corona radiata in the MCI group than the control group. Conclusion: TBSS analysis is a promising method to examine structural WM integrity. These findings suggested that the DTI measurements may be useful for the detection of preclinical changes in AD.

 Purpose: To compare white matter WM structural alterations between the subjects with amnestic mild cognitive impairment MCI which is a transitional state to Alzheimers Disease AD and healthy elderly controls. Methods: Diffusion tensor imaging DTI scans of 20 subjects with amnestic MCI and 20 healthy control groups who are matched by age, gender, and education with the MCI group between 2011 and 2016 were examined by in this retrospective study. WM structural integrity was analyzed using tract based spatial statistics TBSS for voxel-based differences in fractional anisotropy FA between the two groups. Results: Fractional anisotropy was found significantly lower in the forceps minor, the body and genu of the corpus callosum, the right anterior thalamic radiation, the right cingulum, the right inferior fronto-occipital fasciculus, the right superior longitudinal fasciculus, and the right superior corona radiata in the MCI group than the control group. Conclusion: TBSS analysis is a promising method to examine structural WM integrity. These findings suggested that the DTI measurements may be useful for the detection of preclinical changes in AD.

 Amaç: Alzheimer Hastalığına geçiş durumu olan amnestik hafif kognitif bozukluğu HKB olan olgular ile sağlıklı yaşlı kontroller arasındaki beyaz cevher yapısal değişikliklerini karşılaştırmaktır. Gereç ve Yöntem: Bu retrospektif çalışmada, 20 amnestik HKB ile yaş, cinsiyet ve eğitim açısından HKB grubu ile eşleştirilmiş 20 sağlıklı kontrol grubunun 2011-2016 arasındaki difüzyon tensör görüntüleme DTG taramaları incelendi. Beyaz cevher yapısal bütünlüğü, iki grup arasındaki fraksiyonel anizotropide FA voksel bazlı farklılıklar için yolak tabanlı uzamsal istatistik TBSS kullanılarak analiz edildi. Bulgular: Forseps minör, korpus kallozumun genu ve gövdesi, sağ anterior talamik radyasyon, sağ singulum, sağ inferior fronto oksipital fasikül, sağ superior longitudinal fasikül ve sağ üst korona radiatada FA değerleri kontrol grubuna göre HKB grubunda istatistiksel olarak düşük bulundu. Sonuç: TBSS analizi, yapısal beyaz cevher bütünlüğünü incelemek için umut verici bir yöntemdir. Bu bulgular, DTG ölçümlerinin Alzheimerdaki klinik öncesi değişikliklerin saptanması için yararlı olabileceğini düşündürdü.

Article Details

White matter alterations in amnestic mild cognitive impairment: a tract-based spatial statistics study

Authors:

Berrin Çavuşoğlu | Emel Ada | Derya Durusu Emek Savaş | Görsev Yener

Publisher:

Dokuz Eylul University

Main Topics:

Radyoloji ve Organ Görüntüleme

Journal:

Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi Vol.36 Issue 3, pp.267-274

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001283143

pISSN:

2602-3148

Mild cognitive impairment

magnetic resonance imaging

diffusion tensor imaging

tract based spatial statistics

fractional anisotropy

Hafif kognitif bozukluk

manyetik rezonans görüntüleme

difüzyon tensör görüntüleme

yolak tabanlı uzamsal istatistik

fraksiyonel anizotropi

Issues

Article Details

Authors: Berrin Çavuşoğlu | Emel Ada | Derya Durusu Emek Savaş | Görsev Yener

Publisher: Dokuz Eylul University

Main Topics: Radyoloji ve Organ Görüntüleme

Journal: Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi Vol.36 Issue 3, pp.267-274

Document Type: Article

Publication Date: 1/2023

Document Language: English

Document ID (Org No.): 2001283143

pISSN: 2602-3148

Issues

Authors:

Berrin Çavuşoğlu | Emel Ada | Derya Durusu Emek Savaş | Görsev Yener

Publisher:

Dokuz Eylul University

Main Topics:

Radyoloji ve Organ Görüntüleme

Journal:

Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi Vol.36 Issue 3, pp.267-274

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001283143

pISSN:

2602-3148