Frequency of BCR-ABL 1 Fusion Transcripts Variants in Chronic Myeloid Leukemia Algerian patients

Nachi Mourad; Kihek Ibtissem; Entasoltan Badra; Taibi Karima; Guella Mohamed Djaoued; Abed Amine; Boukhatmi Yasmine; Bekadja Mohamed Amine

Article Details

Frequency of BCR-ABL 1 Fusion Transcripts Variants in Chronic Myeloid Leukemia Algerian patients

Authors:

Nachi Mourad | Kihek Ibtissem | Entasoltan Badra | Taibi Karima | Guella Mohamed Djaoued | Abed Amine | Boukhatmi Yasmine | Bekadja Mohamed Amine

Publisher:

Université Oran 1 Ahmed Ben bella

Journal:

Journal de la Faculté de Médecine Vol.4 Issue 1, pp.527-532

Document Type:

Article

Publication Date:

6/2020

Document Language:

English

Document ID (Org No.):

2001452542

pISSN:

2602-6511

Keywords:

Abstract:

 Aim. In chronic myeloid leukemia (CML), the research of BCR-ABL1 fusion transcript became essential to confirm the molecular diagnosis. In this study, we describe the different types of BCR-ABL1 fusion transcripts found in CML patients in West Algerian patients.

Methods. A total of 167 CML suspected patients were included in our study. A qualitative research on fusion transcripts was carried out by reverse transcription polymerase chain reaction (RT-PCR) technique in the biochemistry laboratory of Oran’s university hospital establishment.

Results. The two types of major BCR-ABL1 fusion transcript Mb3a2 and Mb2a2 were present in 59,8 % and 36,4% of cases respectively. Two patients (1,8%) had an atypical and rare transcript type e19a2 and two others (1,8%) co-expressed b3a2 and b2a2 transcript types. 

Conclusion. Our study confirmed the data in the literature with a higher incidence of the major transcript.

Article Details

Frequency of BCR-ABL 1 Fusion Transcripts Variants in Chronic Myeloid Leukemia Algerian patients

Authors:

Nachi Mourad | Kihek Ibtissem | Entasoltan Badra | Taibi Karima | Guella Mohamed Djaoued | Abed Amine | Boukhatmi Yasmine | Bekadja Mohamed Amine

Publisher:

Université Oran 1 Ahmed Ben bella

Journal:

Journal de la Faculté de Médecine Vol.4 Issue 1, pp.527-532

Document Type:

Article

Publication Date:

6/2020

Document Language:

English

Document ID (Org No.):

2001452542

pISSN:

2602-6511

Chronic Myeloid Leukemia

multiplex RT

PCR

BCR

ABL1 Transcript

rare fusion transcripts

Co

expression b3a2/b2a2

Issues

Article Details

Authors: Nachi Mourad | Kihek Ibtissem | Entasoltan Badra | Taibi Karima | Guella Mohamed Djaoued | Abed Amine | Boukhatmi Yasmine | Bekadja Mohamed Amine

Publisher: Université Oran 1 Ahmed Ben bella

Journal: Journal de la Faculté de Médecine Vol.4 Issue 1, pp.527-532

Document Type: Article

Publication Date: 6/2020

Document Language: English

Document ID (Org No.): 2001452542

pISSN: 2602-6511

Issues

Authors:

Nachi Mourad | Kihek Ibtissem | Entasoltan Badra | Taibi Karima | Guella Mohamed Djaoued | Abed Amine | Boukhatmi Yasmine | Bekadja Mohamed Amine

Publisher:

Université Oran 1 Ahmed Ben bella

Journal:

Journal de la Faculté de Médecine Vol.4 Issue 1, pp.527-532

Document Type:

Article

Publication Date:

6/2020

Document Language:

English

Document ID (Org No.):

2001452542

pISSN:

2602-6511