Is there a predictive value of systemic inflammatory parameters and prognostic nutritional index in the detection of lymphatic metastases in papillary thyroid cancers?

Ali Özdemir; Osman Bandırmalı

Article Details

Is there a predictive value of systemic inflammatory parameters and prognostic nutritional index in the detection of lymphatic metastases in papillary thyroid cancers?

Authors:

Ali Özdemir | Osman Bandırmalı

Publisher:

Ondokuz Mayıs University

Main Topics:

General Surgery

Journal:

Deneysel ve Klinik Tıp Dergisi Vol.41 Issue 1, pp.14-19

Document Type:

Article

Publication Date:

3/2024

Document Language:

English

Document ID (Org No.):

2001314292

pISSN:

1309-4483

Keywords:

Abstract:

 This study aimed to assess the predictive value of systemic inflammatory parameters and the prognostic nutritional index PNI in identifying lymphatic metastases in papillary thyroid cancers PTC. PTCs, characterized by their in dolent nature and favorable prognosis, frequently disseminate to cervical lymphnodes, impacting recurrence and prognosis. However, the preoperative identification rate of cervical lymphnode metastases ranges from 20 to 75, necessitating supplemental examinations for precise detection and surgical planning. A retrospective analysis of 441 thyroidectomy cases, encompassing 272 PTC patients, was conducted. Patients were categorized into two cohorts: 221 lacked lymphnode metastases, while 51 exhibited lymphatic metastases. Parameters including age, gender, systemic inflammatory markers derived from hemogram tests, serum albumin levels, and postoperative histopathology findings were scrutinized to evaluate the predictive potential of systemic inflammatory parameters and PNI in discerning between the two cohorts. The findings revealed that neutrophil-to-lymphocyte ratio NLR, platelet-to-lymphocyte ratio PLR, and systemic immune-inflammation index SII values bore statistically significant predictive capacity p0.05 in preoperatively detecting cervical lymphnode metastases in PTC. Receiver operating characteristic ROC curves delineated the efficacy of NLR, PLR, and SII in prognostication. NLR exhibited an area under the curve AUC value of 0.932 95 CI, 0.902-0.962; p0.001, while PLR yielded an AUC value of 0.638 95 CI, 0.555-0.721; p0.002. SII analysis yielded an AUC value of 0.798 95 CI, 0.736-0.861; p0.001. Conversely, the prognostic nutritional index PNI demonstrated meager predictive utility, registering an AUC value of 0.192 95 CI, 0.124-0.260; p0.001, positioning below the reference line on the ROC curve. In conclusion, this study under scores NLRs utility in identifying cervical lymphnode metastases in PTC. While PLR and SII evince some association with lymphnode metastasis detection, their predictive efficacy remains constrained. Additionally, despite statistical significance, PNI exhibited in efficacy in forecasting lymphnode metastases.

 This study aimed to assess the predictive value of systemic inflammatory parameters and the prognostic nutritional index PNI in identifying lymphatic metastases in papillary thyroid cancers PTC. PTCs, characterized by their in dolent nature and favorable prognosis, frequently disseminate to cervical lymphnodes, impacting recurrence and prognosis. However, the preoperative identification rate of cervical lymphnode metastases ranges from 20 to 75, necessitating supplemental examinations for precise detection and surgical planning. A retrospective analysis of 441 thyroidectomy cases, encompassing 272 PTC patients, was conducted. Patients were categorized into two cohorts: 221 lacked lymphnode metastases, while 51 exhibited lymphatic metastases. Parameters including age, gender, systemic inflammatory markers derived from hemogram tests, serum albumin levels, and postoperative histopathology findings were scrutinized to evaluate the predictive potential of systemic inflammatory parameters and PNI in discerning between the two cohorts. The findings revealed that neutrophil-to-lymphocyte ratio NLR, platelet-to-lymphocyte ratio PLR, and systemic immune-inflammation index SII values bore statistically significant predictive capacity p0.05 in preoperatively detecting cervical lymphnode metastases in PTC. Receiver operating characteristic ROC curves delineated the efficacy of NLR, PLR, and SII in prognostication. NLR exhibited an area under the curve AUC value of 0.932 95 CI, 0.902-0.962; p0.001, while PLR yielded an AUC value of 0.638 95 CI, 0.555-0.721; p0.002. SII analysis yielded an AUC value of 0.798 95 CI, 0.736-0.861; p0.001. Conversely, the prognostic nutritional index PNI demonstrated meager predictive utility, registering an AUC value of 0.192 95 CI, 0.124-0.260; p0.001, positioning below the reference line on the ROC curve. In conclusion, this study under scores NLRs utility in identifying cervical lymphnode metastases in PTC. While PLR and SII evince some association with lymphnode metastasis detection, their predictive efficacy remains constrained. Additionally, despite statistical significance, PNI exhibited in efficacy in forecasting lymphnode metastases.

 This study aimed to assess the predictive value of systemic inflammatory parameters and the prognostic nutritional index PNI in identifying lymphatic metastases in papillary thyroid cancers PTC. PTCs, characterized by their in dolent nature and favorable prognosis, frequently disseminate to cervical lymphnodes, impacting recurrence and prognosis. However, the preoperative identification rate of cervical lymphnode metastases ranges from 20 to 75, necessitating supplemental examinations for precise detection and surgical planning. A retrospective analysis of 441 thyroidectomy cases, encompassing 272 PTC patients, was conducted. Patients were categorized into two cohorts: 221 lacked lymphnode metastases, while 51 exhibited lymphatic metastases. Parameters including age, gender, systemic inflammatory markers derived from hemogram tests, serum albumin levels, and postoperative histopathology findings were scrutinized to evaluate the predictive potential of systemic inflammatory parameters and PNI in discerning between the two cohorts. The findings revealed that neutrophil-to-lymphocyte ratio NLR, platelet-to-lymphocyte ratio PLR, and systemic immune-inflammation index SII values bore statistically significant predictive capacity p0.05 in preoperatively detecting cervical lymphnode metastases in PTC. Receiver operating characteristic ROC curves delineated the efficacy of NLR, PLR, and SII in prognostication. NLR exhibited an area under the curve AUC value of 0.932 95 CI, 0.902-0.962; p0.001, while PLR yielded an AUC value of 0.638 95 CI, 0.555-0.721; p0.002. SII analysis yielded an AUC value of 0.798 95 CI, 0.736-0.861; p0.001. Conversely, the prognostic nutritional index PNI demonstrated meager predictive utility, registering an AUC value of 0.192 95 CI, 0.124-0.260; p0.001, positioning below the reference line on the ROC curve. In conclusion, this study under scores NLRs utility in identifying cervical lymphnode metastases in PTC. While PLR and SII evince some association with lymphnode metastasis detection, their predictive efficacy remains constrained. Additionally, despite statistical significance, PNI exhibited in efficacy in forecasting lymphnode metastases.

 This study aimed to assess the predictive value of systemic inflammatory parameters and the prognostic nutritional index PNI in identifying lymphatic metastases in papillary thyroid cancers PTC. PTCs, characterized by their in dolent nature and favorable prognosis, frequently disseminate to cervical lymphnodes, impacting recurrence and prognosis. However, the preoperative identification rate of cervical lymphnode metastases ranges from 20 to 75, necessitating supplemental examinations for precise detection and surgical planning. A retrospective analysis of 441 thyroidectomy cases, encompassing 272 PTC patients, was conducted. Patients were categorized into two cohorts: 221 lacked lymphnode metastases, while 51 exhibited lymphatic metastases. Parameters including age, gender, systemic inflammatory markers derived from hemogram tests, serum albumin levels, and postoperative histopathology findings were scrutinized to evaluate the predictive potential of systemic inflammatory parameters and PNI in discerning between the two cohorts. The findings revealed that neutrophil-to-lymphocyte ratio NLR, platelet-to-lymphocyte ratio PLR, and systemic immune-inflammation index SII values bore statistically significant predictive capacity p0.05 in preoperatively detecting cervical lymphnode metastases in PTC. Receiver operating characteristic ROC curves delineated the efficacy of NLR, PLR, and SII in prognostication. NLR exhibited an area under the curve AUC value of 0.932 95 CI, 0.902-0.962; p0.001, while PLR yielded an AUC value of 0.638 95 CI, 0.555-0.721; p0.002. SII analysis yielded an AUC value of 0.798 95 CI, 0.736-0.861; p0.001. Conversely, the prognostic nutritional index PNI demonstrated meager predictive utility, registering an AUC value of 0.192 95 CI, 0.124-0.260; p0.001, positioning below the reference line on the ROC curve. In conclusion, this study under scores NLRs utility in identifying cervical lymphnode metastases in PTC. While PLR and SII evince some association with lymphnode metastasis detection, their predictive efficacy remains constrained. Additionally, despite statistical significance, PNI exhibited in efficacy in forecasting lymphnode metastases.

Article Details

Is there a predictive value of systemic inflammatory parameters and prognostic nutritional index in the detection of lymphatic metastases in papillary thyroid cancers?

Authors:

Ali Özdemir | Osman Bandırmalı

Publisher:

Ondokuz Mayıs University

Main Topics:

General Surgery

Journal:

Deneysel ve Klinik Tıp Dergisi Vol.41 Issue 1, pp.14-19

Document Type:

Article

Publication Date:

3/2024

Document Language:

English

Document ID (Org No.):

2001314292

pISSN:

1309-4483

Papillary thyroid carcinomas

Lymph node metastasis

Prognostic nutritional index

Inflammatory markers.Papiller tiroid karsinomları

Issues

Article Details

Is there a predictive value of systemic inflammatory parameters and prognostic nutritional index in the detection of lymphatic metastases in papillary thyroid cancers?

Authors: Ali Özdemir | Osman Bandırmalı

Publisher: Ondokuz Mayıs University

Main Topics: General Surgery

Journal: Deneysel ve Klinik Tıp Dergisi Vol.41 Issue 1, pp.14-19

Document Type: Article

Publication Date: 3/2024

Document Language: English

Document ID (Org No.): 2001314292

pISSN: 1309-4483

Papillary thyroid carcinomas

Lymph node metastasis

Prognostic nutritional index

Inflammatory markers.Papiller tiroid karsinomları

Issues

Authors:

Ali Özdemir | Osman Bandırmalı

Publisher:

Ondokuz Mayıs University

Main Topics:

General Surgery

Journal:

Deneysel ve Klinik Tıp Dergisi Vol.41 Issue 1, pp.14-19

Document Type:

Article

Publication Date:

3/2024

Document Language:

English

Document ID (Org No.):

2001314292

pISSN:

1309-4483