Evaluating Frailty and Exercise Capacity in Liver Cirrhosis: Comparative Insights from Field Tests

Bilge Taşkın Gürel; Melda Saglam; Onur Keskin; Ferhat Ünal; Naciye Vardar Yaglı

Article Details

Evaluating Frailty and Exercise Capacity in Liver Cirrhosis: Comparative Insights from Field Tests

Authors:

Bilge Taşkın Gürel | Melda Saglam | Onur Keskin | Ferhat Ünal | Naciye Vardar Yaglı

Publisher:

Hacettepe University

Main Topics:

Physiotherapy

Journal:

Journal of Hacettepe University Physical Therapy and Rehabilitation Faculty Vol.3 Issue 1, pp.18-25

Document Type:

Article

Publication Date:

1/2025

Document Language:

English

Document ID (Org No.):

2001340129

pISSN:

3023-5073

Keywords:

Abstract:

 Purpose: Liver cirrhosis, a chronic disease marked by progressive liver dysfunction, leads to increased frailty and diminished physical performance. We aimed to assess frailty and exercise capacity in individuals with cirrhosis using field tests and evaluate their correlation with frailty. Method: Participants demographic data and Model for End-stage Liver Disease MELD scores were recorded. Field tests included the Incremental Shuttle Walk Test ISWT, 6-Minute Walk Test 6MWT, and 1-Minute Sit-to-Stand Test 1MSTST. Frailty was evaluated using the Liver Frailty Index LFI, comprising chair stands, grip strength, and balance. Results: Twenty-four patients were included in the study, with 85 identified as frail or pre-frail according to the LFI. A strong correlation was found between the 6MWT and ISWT r0.783; p0.001, and a moderate correlation between the 6MWT and 1MSTST r0.604; p0.004. The ISWT had a strong positive relationship with 1MSTST r0.713; p0.001. Physical frailty scores were negatively correlated with the 6MWT r-0.474; p0.035, ISWT r-0.582; p0.009, and 1MSTST r-0.654; p0.002. Principal component analysis PCA revealed component loadings in descending order: ISWT 0.956, 6MWT 0.859, and 1MSTST 0.818. Discussion: This study identified a significant association between various field tests and frailty status in patients with liver cirrhosis. All field tests demonstrated a negative correlation with frailty. The strong correlation between the exercise tests and PCA results highlights ISWT as a key indicator of overall physical performance. These findings suggest that ISWT, along with the 6MWT and 1MSTST, can reliably assess physical frailty and exercise capacity in patients with liver cirrhosis.

 Purpose: Liver cirrhosis, a chronic disease marked by progressive liver dysfunction, leads to increased frailty and diminished physical performance. We aimed to assess frailty and exercise capacity in individuals with cirrhosis using field tests and evaluate their correlation with frailty. Method: Participants demographic data and Model for End-stage Liver Disease MELD scores were recorded. Field tests included the Incremental Shuttle Walk Test ISWT, 6-Minute Walk Test 6MWT, and 1-Minute Sit-to-Stand Test 1MSTST. Frailty was evaluated using the Liver Frailty Index LFI, comprising chair stands, grip strength, and balance. Results: Twenty-four patients were included in the study, with 85 identified as frail or pre-frail according to the LFI. A strong correlation was found between the 6MWT and ISWT r0.783; p0.001, and a moderate correlation between the 6MWT and 1MSTST r0.604; p0.004. The ISWT had a strong positive relationship with 1MSTST r0.713; p0.001. Physical frailty scores were negatively correlated with the 6MWT r-0.474; p0.035, ISWT r-0.582; p0.009, and 1MSTST r-0.654; p0.002. Principal component analysis PCA revealed component loadings in descending order: ISWT 0.956, 6MWT 0.859, and 1MSTST 0.818. Discussion: This study identified a significant association between various field tests and frailty status in patients with liver cirrhosis. All field tests demonstrated a negative correlation with frailty. The strong correlation between the exercise tests and PCA results highlights ISWT as a key indicator of overall physical performance. These findings suggest that ISWT, along with the 6MWT and 1MSTST, can reliably assess physical frailty and exercise capacity in patients with liver cirrhosis.

 Purpose: Liver cirrhosis, a chronic disease marked by progressive liver dysfunction, leads to increased frailty and diminished physical performance. We aimed to assess frailty and exercise capacity in individuals with cirrhosis using field tests and evaluate their correlation with frailty. Method: Participants demographic data and Model for End-stage Liver Disease MELD scores were recorded. Field tests included the Incremental Shuttle Walk Test ISWT, 6-Minute Walk Test 6MWT, and 1-Minute Sit-to-Stand Test 1MSTST. Frailty was evaluated using the Liver Frailty Index LFI, comprising chair stands, grip strength, and balance. Results: Twenty-four patients were included in the study, with 85 identified as frail or pre-frail according to the LFI. A strong correlation was found between the 6MWT and ISWT r0.783; p0.001, and a moderate correlation between the 6MWT and 1MSTST r0.604; p0.004. The ISWT had a strong positive relationship with 1MSTST r0.713; p0.001. Physical frailty scores were negatively correlated with the 6MWT r-0.474; p0.035, ISWT r-0.582; p0.009, and 1MSTST r-0.654; p0.002. Principal component analysis PCA revealed component loadings in descending order: ISWT 0.956, 6MWT 0.859, and 1MSTST 0.818. Discussion: This study identified a significant association between various field tests and frailty status in patients with liver cirrhosis. All field tests demonstrated a negative correlation with frailty. The strong correlation between the exercise tests and PCA results highlights ISWT as a key indicator of overall physical performance. These findings suggest that ISWT, along with the 6MWT and 1MSTST, can reliably assess physical frailty and exercise capacity in patients with liver cirrhosis.

 Purpose: Liver cirrhosis, a chronic disease marked by progressive liver dysfunction, leads to increased frailty and diminished physical performance. We aimed to assess frailty and exercise capacity in individuals with cirrhosis using field tests and evaluate their correlation with frailty. Method: Participants demographic data and Model for End-stage Liver Disease MELD scores were recorded. Field tests included the Incremental Shuttle Walk Test ISWT, 6-Minute Walk Test 6MWT, and 1-Minute Sit-to-Stand Test 1MSTST. Frailty was evaluated using the Liver Frailty Index LFI, comprising chair stands, grip strength, and balance. Results: Twenty-four patients were included in the study, with 85 identified as frail or pre-frail according to the LFI. A strong correlation was found between the 6MWT and ISWT r0.783; p0.001, and a moderate correlation between the 6MWT and 1MSTST r0.604; p0.004. The ISWT had a strong positive relationship with 1MSTST r0.713; p0.001. Physical frailty scores were negatively correlated with the 6MWT r-0.474; p0.035, ISWT r-0.582; p0.009, and 1MSTST r-0.654; p0.002. Principal component analysis PCA revealed component loadings in descending order: ISWT 0.956, 6MWT 0.859, and 1MSTST 0.818. Discussion: This study identified a significant association between various field tests and frailty status in patients with liver cirrhosis. All field tests demonstrated a negative correlation with frailty. The strong correlation between the exercise tests and PCA results highlights ISWT as a key indicator of overall physical performance. These findings suggest that ISWT, along with the 6MWT and 1MSTST, can reliably assess physical frailty and exercise capacity in patients with liver cirrhosis.

Article Details

Evaluating Frailty and Exercise Capacity in Liver Cirrhosis: Comparative Insights from Field Tests

Authors:

Bilge Taşkın Gürel | Melda Saglam | Onur Keskin | Ferhat Ünal | Naciye Vardar Yaglı

Publisher:

Hacettepe University

Main Topics:

Physiotherapy

Journal:

Journal of Hacettepe University Physical Therapy and Rehabilitation Faculty Vol.3 Issue 1, pp.18-25

Document Type:

Article

Publication Date:

1/2025

Document Language:

English

Document ID (Org No.):

2001340129

pISSN:

3023-5073

exercise test

frailty

liver cirrhosis

sarcopenia

Issues

Article Details

Evaluating Frailty and Exercise Capacity in Liver Cirrhosis: Comparative Insights from Field Tests

Authors: Bilge Taşkın Gürel | Melda Saglam | Onur Keskin | Ferhat Ünal | Naciye Vardar Yaglı

Publisher: Hacettepe University

Main Topics: Physiotherapy

Journal: Journal of Hacettepe University Physical Therapy and Rehabilitation Faculty Vol.3 Issue 1, pp.18-25

Document Type: Article

Publication Date: 1/2025

Document Language: English

Document ID (Org No.): 2001340129

pISSN: 3023-5073

exercise test

frailty

liver cirrhosis

sarcopenia

Issues

Authors:

Bilge Taşkın Gürel | Melda Saglam | Onur Keskin | Ferhat Ünal | Naciye Vardar Yaglı

Publisher:

Hacettepe University

Main Topics:

Physiotherapy

Journal:

Journal of Hacettepe University Physical Therapy and Rehabilitation Faculty Vol.3 Issue 1, pp.18-25

Document Type:

Article

Publication Date:

1/2025

Document Language:

English

Document ID (Org No.):

2001340129

pISSN:

3023-5073