Assessment of serum Cystatin-C, Cortisol and  Aldosterone hormone as markers for early detection of  nephropathy among Iraqi patients with Type 2 Diabetes  Mellitus

Noor Thair Tahir

Article Details

Assessment of serum Cystatin-C, Cortisol and Aldosterone hormone as markers for early detection of nephropathy among Iraqi patients with Type 2 Diabetes Mellitus

Authors:

Noor Thair Tahir

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.29 Issue 1, pp.469-475

Document Type:

Article

Publication Date:

3/2025

Document Language:

English

Document ID (Org No.):

2001339626

pISSN:

2630-6344

Keywords:

Abstract:

 Biomarkers which identify Diabetic nephropathy DN patients could allow early, more efficient intervention and management, decreasing patient morbidity and mortality. This study aimed to estimate the predictive value of cystatin-c protein, and the hormones cortisol and aldosterone in detecting DN in a study including 60 patients with DN under hemodialysis HD and other 60 patients with type 2 diabetes mellitus T2DM who were recruited from AL-Yarmouk, AL-Kindy and AL- Karama Teaching Hospitals dialysis center. Serum levels of cystatin-c, cortisol, and aldosterone were measured for both groups. Serum cystatin-c protein, cortisol and aldosterone hormones levels were significantly higher in patients with DN under HD when it compared with T2DM patients. Receiver operating characteristic ROC curve was utilized to test the cut off values of these biomarkers to predict DN results revealed that serum cystatin-c, cortisol and aldosterone levels were significantly higher in patients with DN under HD when it compared with T2DM patients. ROC analysis revealed that the cystatin-C level had the best predictive value in detecting of DN compared with serum cortisol and aldosterone which indicate that cystatin-C could be used to predict DN development and progression in patients with T2DM.

 Biomarkers which identify Diabetic nephropathy DN patients could allow early, more efficient intervention and management, decreasing patient morbidity and mortality. This study aimed to estimate the predictive value of cystatin-c protein, and the hormones cortisol and aldosterone in detecting DN in a study including 60 patients with DN under hemodialysis HD and other 60 patients with type 2 diabetes mellitus T2DM who were recruited from AL-Yarmouk, AL-Kindy and AL- Karama Teaching Hospitals dialysis center. Serum levels of cystatin-c, cortisol, and aldosterone were measured for both groups. Serum cystatin-c protein, cortisol and aldosterone hormones levels were significantly higher in patients with DN under HD when it compared with T2DM patients. Receiver operating characteristic ROC curve was utilized to test the cut off values of these biomarkers to predict DN results revealed that serum cystatin-c, cortisol and aldosterone levels were significantly higher in patients with DN under HD when it compared with T2DM patients. ROC analysis revealed that the cystatin-C level had the best predictive value in detecting of DN compared with serum cortisol and aldosterone which indicate that cystatin-C could be used to predict DN development and progression in patients with T2DM.

 Biomarkers which identify Diabetic nephropathy DN patients could allow early, more efficient intervention and management, decreasing patient morbidity and mortality. This study aimed to estimate the predictive value of cystatin-c protein, and the hormones cortisol and aldosterone in detecting DN in a study including 60 patients with DN under hemodialysis HD and other 60 patients with type 2 diabetes mellitus T2DM who were recruited from AL-Yarmouk, AL-Kindy and AL- Karama Teaching Hospitals dialysis center. Serum levels of cystatin-c, cortisol, and aldosterone were measured for both groups. Serum cystatin-c protein, cortisol and aldosterone hormones levels were significantly higher in patients with DN under HD when it compared with T2DM patients. Receiver operating characteristic ROC curve was utilized to test the cut off values of these biomarkers to predict DN results revealed that serum cystatin-c, cortisol and aldosterone levels were significantly higher in patients with DN under HD when it compared with T2DM patients. ROC analysis revealed that the cystatin-C level had the best predictive value in detecting of DN compared with serum cortisol and aldosterone which indicate that cystatin-C could be used to predict DN development and progression in patients with T2DM.

 Biomarkers which identify Diabetic nephropathy DN patients could allow early, more efficient intervention and management, decreasing patient morbidity and mortality. This study aimed to estimate the predictive value of cystatin-c protein, and the hormones cortisol and aldosterone in detecting DN in a study including 60 patients with DN under hemodialysis HD and other 60 patients with type 2 diabetes mellitus T2DM who were recruited from AL-Yarmouk, AL-Kindy and AL- Karama Teaching Hospitals dialysis center. Serum levels of cystatin-c, cortisol, and aldosterone were measured for both groups. Serum cystatin-c protein, cortisol and aldosterone hormones levels were significantly higher in patients with DN under HD when it compared with T2DM patients. Receiver operating characteristic ROC curve was utilized to test the cut off values of these biomarkers to predict DN results revealed that serum cystatin-c, cortisol and aldosterone levels were significantly higher in patients with DN under HD when it compared with T2DM patients. ROC analysis revealed that the cystatin-C level had the best predictive value in detecting of DN compared with serum cortisol and aldosterone which indicate that cystatin-C could be used to predict DN development and progression in patients with T2DM.

Article Details

Assessment of serum Cystatin-C, Cortisol and Aldosterone hormone as markers for early detection of nephropathy among Iraqi patients with Type 2 Diabetes Mellitus

Authors:

Noor Thair Tahir

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.29 Issue 1, pp.469-475

Document Type:

Article

Publication Date:

3/2025

Document Language:

English

Document ID (Org No.):

2001339626

pISSN:

2630-6344

Diabetes mellitus

Diabetic nephropathy

Cystatin-c

Cortisol

Aldosterone

Issues

Article Details

Assessment of serum Cystatin-C, Cortisol and Aldosterone hormone as markers for early detection of nephropathy among Iraqi patients with Type 2 Diabetes Mellitus

Authors: Noor Thair Tahir

Publisher: Marmara University

Main Topics: Pharmacology and Pharmaceutical Sciences (Other)

Journal: Journal of Research in Pharmacy Vol.29 Issue 1, pp.469-475

Document Type: Article

Publication Date: 3/2025

Document Language: English

Document ID (Org No.): 2001339626

pISSN: 2630-6344

Diabetes mellitus

Diabetic nephropathy

Cystatin-c

Cortisol

Aldosterone

Issues

Authors:

Noor Thair Tahir

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.29 Issue 1, pp.469-475

Document Type:

Article

Publication Date:

3/2025

Document Language:

English

Document ID (Org No.):

2001339626

pISSN:

2630-6344