Ultrasound-Assisted Synthesis of Some New N-(Substituted Carboxylic Acid-2-yl)-6-Methyl-4-Substituted Phenyl-3, 4-Dihydropyrimidine-2(1H)-One Carboxamides

Karzan K. Hameed; Faiq H. S. Hussain

doi:10.23918/eajse.v4i2p61

Article Details

Ultrasound-Assisted Synthesis of Some New N-(Substituted Carboxylic Acid-2-yl)-6-Methyl-4-Substituted Phenyl-3, 4-Dihydropyrimidine-2(1H)-One Carboxamides

Authors:

Karzan K. Hameed | Faiq H. S. Hussain

Publisher:

Tishk International University

Main Topics:

Dihydropyrimidinone | Biginelli Reaction | Lacl3.7H2O | Amino Acids | Ultrasonic Technique | Green Chemistry

Journal:

EURASIAN JOURNAL OF SCIENCE AND ENGINEERING Vol.4 Issue 2, pp.61-73

Document Type:

Article

Publication Date:

1/2018

Document Language:

English

Document ID (Org No.):

2001364853

pISSN:

2414-5602

DOI:

10.23918/eajse.v4i2p61

Keywords:

Abstract:

 In this work, the starting material 6-methyl-4- substituted phenyl-3,4-dihydropyrimidine-2- (1H)-one-5-carboxylic acid ethyl ester (3a,b) have been prepared from the condensation of benzaldehyde (or anisaldehyde), urea and ethyl acetoacetate, in presence of an acid in ethanol under sonication, then hydrolysed to the corresponding acids (4a,b) which were chlorinated with SOCl2 to produce 6-methyl- 4-substituted phenyl-3, 4-dihydropyrimidine-2-(1H)-one-carbonyl chloride (5a,b). The compounds (5a,b) then subjected to react with different amino acids in the presence of LaCl3.7H2O as a catalyst using a green method (ultrasound assisted technique) to give a new series of N-(Substituted carboxylic acid-2- yl)-6-methyl-4-substituted phenyl-3,4- dihydropyrimidine-2-(1H)-one-5-carboxamide (6a-e and 7a-h). The structures of the synthesized compounds were characterized by using FT-IR, 1H-NMR, 13C-NMR and elemental analysis.

Article Details

Ultrasound-Assisted Synthesis of Some New N-(Substituted Carboxylic Acid-2-yl)-6-Methyl-4-Substituted Phenyl-3, 4-Dihydropyrimidine-2(1H)-One Carboxamides

Authors: Karzan K. Hameed | Faiq H. S. Hussain

Publisher: Tishk International University

Main Topics: Dihydropyrimidinone | Biginelli Reaction | Lacl3.7H2O | Amino Acids | Ultrasonic Technique | Green Chemistry

Journal: EURASIAN JOURNAL OF SCIENCE AND ENGINEERING Vol.4 Issue 2, pp.61-73

Document Type: Article

Publication Date: 1/2018

Document Language: English

Document ID (Org No.): 2001364853

pISSN: 2414-5602

DOI: 10.23918/eajse.v4i2p61

Dihydropyrimidinone

Biginelli Reaction

Lacl3.7H2O

Amino Acids

Ultrasonic Technique

Green Chemistry

Issues

Authors:

Karzan K. Hameed | Faiq H. S. Hussain

Publisher:

Tishk International University

Main Topics:

Dihydropyrimidinone | Biginelli Reaction | Lacl3.7H2O | Amino Acids | Ultrasonic Technique | Green Chemistry

Journal:

EURASIAN JOURNAL OF SCIENCE AND ENGINEERING Vol.4 Issue 2, pp.61-73

Document Type:

Article

Publication Date:

1/2018

Document Language:

English

Document ID (Org No.):

2001364853

pISSN:

2414-5602

DOI:

10.23918/eajse.v4i2p61