Anti-Breast Cancer Activity of Novel Quinoline Palladacycle Compound

Heba K. A. Abed; Abdel-Sattar S. Hamad Elgazwy; Saeb H Al iwaini

Article Details

Anti-Breast Cancer Activity of Novel Quinoline Palladacycle Compound

Authors:

Heba K. A. Abed | Abdel-Sattar S. Hamad Elgazwy | Saeb H Al iwaini

Publisher:

Islamic University of Gaza

Journal:

IUG Journal of Natural Studies Vol.32 Issue 2, pp.0-0

Document Type:

Article

Publication Date:

2/2026

Document Language:

English

Document ID (Org No.):

2001390429

pISSN:

2790-1653

Keywords:

Abstract:

 Breast cancer remains one of the most common cancers among women worldwide, highlighting the ongoing need for novel and effective therapeutic approaches. In this study, we investigated the anticancer activity of a newly synthesized pyrido[1,2-a] quinoline palladacycle compound, designated  4D , using two distinct breast cancer cell lines: estrogen receptor–positive MCF-7 and triple-negative HCC1937. Cytotoxicity measurements using the MTT assay showed a dose-dependent reduction in cell viability, with both cell lines displaying high sensitivity to the compound. Clonogenic survival and growth curve analyses further revealed that  4D  significantly impairs long-term proliferation.  Additionally,  4D  markedly reduced cell motility, increased the expression of cell cycle–regulatory proteins p53 and p21, and induced hallmark features of apoptosis, including DNA fragmentation and PARP cleavage. Together, these findings demonstrate that compound  4D  possesses robust anticancer properties and may serve as a promising candidate for the development of new therapeutic strategies against breast cancer.

Article Details

Anti-Breast Cancer Activity of Novel Quinoline Palladacycle Compound

Authors:

Heba K. A. Abed | Abdel-Sattar S. Hamad Elgazwy | Saeb H Al iwaini

Publisher:

Islamic University of Gaza

Journal:

IUG Journal of Natural Studies Vol.32 Issue 2, pp.0-0

Document Type:

Article

Publication Date:

2/2026

Document Language:

English

Document ID (Org No.):

2001390429

pISSN:

2790-1653

Breast cancer

pyrido[1

2-a] quinoline palladacycle

cell cycle arrest

apoptosis

Issues

Article Details

Anti-Breast Cancer Activity of Novel Quinoline Palladacycle Compound

Authors: Heba K. A. Abed | Abdel-Sattar S. Hamad Elgazwy | Saeb H Al iwaini

Publisher: Islamic University of Gaza

Journal: IUG Journal of Natural Studies Vol.32 Issue 2, pp.0-0

Document Type: Article

Publication Date: 2/2026

Document Language: English

Document ID (Org No.): 2001390429

pISSN: 2790-1653

Breast cancer

pyrido[1

2-a] quinoline palladacycle

cell cycle arrest

apoptosis

Issues

Authors:

Heba K. A. Abed | Abdel-Sattar S. Hamad Elgazwy | Saeb H Al iwaini

Publisher:

Islamic University of Gaza

Journal:

IUG Journal of Natural Studies Vol.32 Issue 2, pp.0-0

Document Type:

Article

Publication Date:

2/2026

Document Language:

English

Document ID (Org No.):

2001390429

pISSN:

2790-1653