Comparison of Efficacy of Hyperthermic Intraperitoneal Chemotherapeutics Mitomycin C versus Oxaliplatin in Experimental Colorectal Peritoneal Metastasis Model

Berke Manoğlu; Aras Emre Canda; Tugba Yavuzşen; Safiye Aktaş; Zekiye Altun; Osman Yılmaz; Tayfun Bişgin

Article Details

Comparison of Efficacy of Hyperthermic Intraperitoneal Chemotherapeutics Mitomycin C versus Oxaliplatin in Experimental Colorectal Peritoneal Metastasis Model

Authors:

Berke Manoğlu | Aras Emre Canda | Tugba Yavuzşen | Safiye Aktaş | Zekiye Altun | Osman Yılmaz | Tayfun Bişgin

Publisher:

Dokuz Eylul University

Main Topics:

Clinical Oncology

Journal:

Journal of Basic and Clinical Health Sciences Vol.8 Issue 1, pp.181-191

Document Type:

Article

Publication Date:

1/2024

Document Language:

English

Document ID (Org No.):

2001310845

pISSN:

2564-7288

Keywords:

Abstract:

 Aim: Our study aimed to establish a mouse model with colorectal cancer-induced peritoneal metastasisPM and to compare the efficacy of hyperthermic intraperitoneal chemotherapeutic agents, mitomycin C and oxaliplatin. Materials and Methods: The peritoneal metastasis model was established in nude mice using the CC531 colon carcinoma cell line. Models with PM were randomized into four groups of seven animals each: Group-1, control group; Group-2, hyperthermic intraperitoneal chemotherapyHIPEC with mitomycin CMMC, and Group-3, HIPEC with OxaliplatinOXA. Results: Tumor development was achieved in all animals. While the tumor burden decreased significantly in the treatment Group-2p.013. In the PM mouse model, hyperthermic intraperitoneal administration of MMC had a higher tumoricidal effect than hyperthermic intraperitoneal administration of OXA. Conclusions: Our PM model provided a good opportunity to examine the efficacy of HIPEC and IPIP. Hyperethermic intraperitoneal mitomycin applied in the colorectal PM animal model was found to have higher tumoricidal activity than oxaliplatin. In future studies, we plan to evaluate efficacies of different drugs in the PM models we have created.

 Aim: Our study aimed to establish a mouse model with colorectal cancer-induced peritoneal metastasisPM and to compare the efficacy of hyperthermic intraperitoneal chemotherapeutic agents, mitomycin C and oxaliplatin. Materials and Methods: The peritoneal metastasis model was established in nude mice using the CC531 colon carcinoma cell line. Models with PM were randomized into four groups of seven animals each: Group-1, control group; Group-2, hyperthermic intraperitoneal chemotherapyHIPEC with mitomycin CMMC, and Group-3, HIPEC with OxaliplatinOXA. Results: Tumor development was achieved in all animals. While the tumor burden decreased significantly in the treatment Group-2p.013. In the PM mouse model, hyperthermic intraperitoneal administration of MMC had a higher tumoricidal effect than hyperthermic intraperitoneal administration of OXA. Conclusions: Our PM model provided a good opportunity to examine the efficacy of HIPEC and IPIP. Hyperethermic intraperitoneal mitomycin applied in the colorectal PM animal model was found to have higher tumoricidal activity than oxaliplatin. In future studies, we plan to evaluate efficacies of different drugs in the PM models we have created.

 Aim: Our study aimed to establish a mouse model with colorectal cancer-induced peritoneal metastasisPM and to compare the efficacy of hyperthermic intraperitoneal chemotherapeutic agents, mitomycin C and oxaliplatin. Materials and Methods: The peritoneal metastasis model was established in nude mice using the CC531 colon carcinoma cell line. Models with PM were randomized into four groups of seven animals each: Group-1, control group; Group-2, hyperthermic intraperitoneal chemotherapyHIPEC with mitomycin CMMC, and Group-3, HIPEC with OxaliplatinOXA. Results: Tumor development was achieved in all animals. While the tumor burden decreased significantly in the treatment Group-2p.013. In the PM mouse model, hyperthermic intraperitoneal administration of MMC had a higher tumoricidal effect than hyperthermic intraperitoneal administration of OXA. Conclusions: Our PM model provided a good opportunity to examine the efficacy of HIPEC and IPIP. Hyperethermic intraperitoneal mitomycin applied in the colorectal PM animal model was found to have higher tumoricidal activity than oxaliplatin. In future studies, we plan to evaluate efficacies of different drugs in the PM models we have created.

 Aim: Our study aimed to establish a mouse model with colorectal cancer-induced peritoneal metastasisPM and to compare the efficacy of hyperthermic intraperitoneal chemotherapeutic agents, mitomycin C and oxaliplatin. Materials and Methods: The peritoneal metastasis model was established in nude mice using the CC531 colon carcinoma cell line. Models with PM were randomized into four groups of seven animals each: Group-1, control group; Group-2, hyperthermic intraperitoneal chemotherapyHIPEC with mitomycin CMMC, and Group-3, HIPEC with OxaliplatinOXA. Results: Tumor development was achieved in all animals. While the tumor burden decreased significantly in the treatment Group-2p.013. In the PM mouse model, hyperthermic intraperitoneal administration of MMC had a higher tumoricidal effect than hyperthermic intraperitoneal administration of OXA. Conclusions: Our PM model provided a good opportunity to examine the efficacy of HIPEC and IPIP. Hyperethermic intraperitoneal mitomycin applied in the colorectal PM animal model was found to have higher tumoricidal activity than oxaliplatin. In future studies, we plan to evaluate efficacies of different drugs in the PM models we have created.

Article Details

Comparison of Efficacy of Hyperthermic Intraperitoneal Chemotherapeutics Mitomycin C versus Oxaliplatin in Experimental Colorectal Peritoneal Metastasis Model

Authors: Berke Manoğlu | Aras Emre Canda | Tugba Yavuzşen | Safiye Aktaş | Zekiye Altun | Osman Yılmaz | Tayfun Bişgin

Publisher: Dokuz Eylul University

Main Topics: Clinical Oncology

Journal: Journal of Basic and Clinical Health Sciences Vol.8 Issue 1, pp.181-191

Document Type: Article

Publication Date: 1/2024

Document Language: English

Document ID (Org No.): 2001310845

pISSN: 2564-7288

peritoneal metastasis model

colorectal cancer

HIPEC

Issues

Authors:

Berke Manoğlu | Aras Emre Canda | Tugba Yavuzşen | Safiye Aktaş | Zekiye Altun | Osman Yılmaz | Tayfun Bişgin

Publisher:

Dokuz Eylul University

Main Topics:

Clinical Oncology

Journal:

Journal of Basic and Clinical Health Sciences Vol.8 Issue 1, pp.181-191

Document Type:

Article

Publication Date:

1/2024

Document Language:

English

Document ID (Org No.):

2001310845

pISSN:

2564-7288