Familial Clustering of Type 2 Diabetes among Omanis

Sawsan Al-Sinani; Mohammed Al-Shafaee; Ali Al-Mamari; Nicholas Woodhouse; Omaima Al-Shafie; Mohammed Hassan; Said Al-Yahyaee; Sulayma Albarwani; Deepali Jaju; Khamis Al-Hashmi; Mohammed Al-Abri; Rizvi , Syed; Riad Bayoumi

doi:10.5001/omj.2014.11

Article Details

Familial Clustering of Type 2 Diabetes among Omanis

Authors:

Sawsan Al-Sinani | Mohammed Al-Shafaee | Ali Al-Mamari | Nicholas Woodhouse | Omaima Al-Shafie | Mohammed Hassan | Said Al-Yahyaee | Sulayma Albarwani | Deepali Jaju | Khamis Al-Hashmi | Mohammed Al-Abri | Rizvi , Syed | Riad Bayoumi

Publisher:

Oman Medical Specialty Board

Main Topics:

Medicine

Journal:

Oman Medical Journal 2014 vol.29 Issue 1, pp.51-54

Document Type:

Article

Publication Date:

1/2014

Document Language:

English

Document ID (Org No.):

40873

Frequency:

Bi-Monthly

eISSN:

20705204

pISSN:

1999768X

DOI:

10.5001/omj.2014.11

Descriptors:

Keywords:

Abstract:

 Objective: The aim of this study was to screen Omani individuals for the familial aggregation of type 2 diabetes mellitus.

Methods: A random cohort of 1182 Omani individuals visiting the Family Medicine Clinic at Sultan Qaboos University Hospital (SQUH), Muscat, Oman, for regular medical checkup, aged ≥40 years, were sampled. Patients were categorized into three groups: (1) individuals who claim not to have diabetes and had no family history of diabetes; (2) individuals who claim not to have diabetes but had family history of diabetes; (3) individuals with diabetes. Only 16% of these Omani individuals had no diabetes and no family history of diabetes. Another separate random cohort of 234 Omani type 2 diabetes mellitus patients, from the Diabetes Clinic at SQUH, were interviewed and questioned about their family history of type 2 diabetes mellitus. 
Results: Ninety five percent of the patients had a family history of diabetes. Eighty percent had first degree relatives with diabetes and 46% had second degree relatives with diabetes. At least one parent with diabetes was reported among 55% of these diabetics, while maternal diabetes (55%) was found to be higher than paternal diabetes (47%). However, only 15% had both parents with diabetes. Furthermore, almost half of the 234 diabetics were having at least one of the following relatives with diabetes: brother, sister, aunt or an uncle. 
Conclusion: The findings of this study confirm familial aggregation of diabetes among the Omani population. Compared to other populations, familial aggregation of type 2 diabetes mellitus among Omanis is relatively very high, and is perhaps due to the very high degree of consanguinity among Omanis. Since almost everyone seems to have a genetic predisposition to diabetes, the dramatic lifestyle changes over the past 25 years, could tip the population into an epidemic of type 2 diabetes mellitus.

Article Details

Familial Clustering of Type 2 Diabetes among Omanis

Authors:

Sawsan Al-Sinani | Mohammed Al-Shafaee | Ali Al-Mamari | Nicholas Woodhouse | Omaima Al-Shafie | Mohammed Hassan | Said Al-Yahyaee | Sulayma Albarwani | Deepali Jaju | Khamis Al-Hashmi | Mohammed Al-Abri | Rizvi , Syed | Riad Bayoumi

Publisher:

Oman Medical Specialty Board

Main Topics:

Medicine

Journal:

Oman Medical Journal 2014 vol.29 Issue 1, pp.51-54

Document Type:

Article

Publication Date:

1/2014

Document Language:

English

Document ID (Org No.):

40873

Frequency:

Bi-Monthly

eISSN:

20705204

pISSN:

1999768X

DOI:

10.5001/omj.2014.11

Descriptors:

DISEASES

DIABETES

MEDICAL EXAMINATION

FAMILY

QUALITY OF LIFE

LABORATORY TESTING

HEALTH CENTRES

OMAN

Type 2 diabetes mellitus

Family clustering

Oman

Issues

Article Details

Authors: Sawsan Al-Sinani | Mohammed Al-Shafaee | Ali Al-Mamari | Nicholas Woodhouse | Omaima Al-Shafie | Mohammed Hassan | Said Al-Yahyaee | Sulayma Albarwani | Deepali Jaju | Khamis Al-Hashmi | Mohammed Al-Abri | Rizvi , Syed | Riad Bayoumi

Publisher: Oman Medical Specialty Board

Main Topics: Medicine

Journal: Oman Medical Journal 2014 vol.29 Issue 1, pp.51-54

Document Type: Article

Publication Date: 1/2014

Document Language: English

Document ID (Org No.): 40873

Frequency: Bi-Monthly

eISSN: 20705204

pISSN: 1999768X

DOI: 10.5001/omj.2014.11

Descriptors:

Issues

Authors:

Sawsan Al-Sinani | Mohammed Al-Shafaee | Ali Al-Mamari | Nicholas Woodhouse | Omaima Al-Shafie | Mohammed Hassan | Said Al-Yahyaee | Sulayma Albarwani | Deepali Jaju | Khamis Al-Hashmi | Mohammed Al-Abri | Rizvi , Syed | Riad Bayoumi

Publisher:

Oman Medical Specialty Board

Main Topics:

Medicine

Journal:

Oman Medical Journal 2014 vol.29 Issue 1, pp.51-54

Document Type:

Article

Publication Date:

1/2014

Document Language:

English

Document ID (Org No.):

40873

Frequency:

Bi-Monthly

eISSN:

20705204

pISSN:

1999768X

DOI:

10.5001/omj.2014.11