Clinical and Genetic Characteristics of Familial Hypercholesterolemia at Sultan Qaboos University Hospital in Oman

Al-Waili , Khalid; Al-Rasadi , Khalid; Zadjali , Fahad; Al-Hashmi , Khamis; Al-Mukhaini , Suad; Al-Kindi , Mohammed; Al-Sabti , Hilal; Al-Hinai , Ali Talib; Farhan , Hatem; Al-Zakwani , Ibrahim

doi:10.5001/omj.2020.59

Article Details

Clinical and Genetic Characteristics of Familial Hypercholesterolemia at Sultan Qaboos University Hospital in Oman

Authors:

Al-Waili , Khalid | Al-Rasadi , Khalid | Zadjali , Fahad | Al-Hashmi , Khamis | Al-Mukhaini , Suad | Al-Kindi , Mohammed | Al-Sabti , Hilal | Al-Hinai , Ali Talib | Farhan , Hatem | Al-Zakwani , Ibrahim

Publisher:

Oman Medical Specialty Board

Main Topics:

Medicine

Journal:

Oman Medical Journal 2020 Vol.35 Issue 3, pp.1-6

Document Type:

Article

Publication Date:

5/2020

Document Language:

English

Document ID (Org No.):

142276

Frequency:

Bi-Monthly

eISSN:

20705204

pISSN:

1999768X

DOI:

10.5001/omj.2020.59

Descriptors:

Keywords:

Abstract:

 Objectives: We sought to describe the clinical and genetic characteristics of patients withfamilial hypercholesterolemia (FH) that presented to the lipid clinic at Sultan QaboosUniversity Hospital, Muscat, Oman. 
Methods: Patients who presented with highlow-density lipoprotein cholesterol (LDL-C) levels (> 189.0 mg/dL or 4.9 mmol/L)were recruited to the study. FH was diagnosed according to the Dutch Lipid ClinicNetwork criteria. Analyses were performed using univariate statistics. 
Results: Thestudy enrolled 450 patients with a mean age of 48.0±12.0 years, 56.0% (n = 252) weremales and 11.3% (n = 51) were smokers. At admission, the proportion of ‘probable/definite’, ‘possible’, and ‘unlikely’ FH were 27.6% (n = 124), 70.0% (n = 315), and 2.4%(n = 11), respectively. Overall, 26.0% (n = 117) of patients had hypertension, 22.4%(n = 101) had a history of coronary artery disease, and 17.3% (n = 78) had diabetes mellitus.Those with ‘probable/definite’ FH were more likely to be prescribed high-intensity statintherapy (75.8% vs. 54.5%; p < 0.001) and statin ezetimibe combination (50.8% vs. 27.3%;p < 0.001) when compared to the ‘unlikely’ FH cohort. Additionally, those with very highatherosclerotic vascular disease (ASCVD) risk were also associated with high-intensitystatin therapy (54.7% vs. 42.7%; p = 0.006) and statin ezetimibe combination (26.4%vs. 17.2%; p = 0.023). Patients with ‘probable/definite’ FH were less likely to achievetheir LDL-C goal attainment compared to those with ‘unlikely’ FH (13.0% vs. 57.1%;p < 0.001). Furthermore, those with very high ASCVD risk were less likely to achieve their LDL-C goals compared to the high ASCVD risk cohort (9.6% vs. 32.0%; p <0.001). 
Conclusions: FH patients are underdiagnosed, undertreated, and less likely toattain their LDL-C goals in Oman.

Article Details

Clinical and Genetic Characteristics of Familial Hypercholesterolemia at Sultan Qaboos University Hospital in Oman

Authors:

Al-Waili , Khalid | Al-Rasadi , Khalid | Zadjali , Fahad | Al-Hashmi , Khamis | Al-Mukhaini , Suad | Al-Kindi , Mohammed | Al-Sabti , Hilal | Al-Hinai , Ali Talib | Farhan , Hatem | Al-Zakwani , Ibrahim

Publisher:

Oman Medical Specialty Board

Main Topics:

Medicine

Journal:

Oman Medical Journal 2020 Vol.35 Issue 3, pp.1-6

Document Type:

Article

Publication Date:

5/2020

Document Language:

English

Document ID (Org No.):

142276

Frequency:

Bi-Monthly

eISSN:

20705204

pISSN:

1999768X

DOI:

10.5001/omj.2020.59

Descriptors:

HYPERCHOLESTEROLAEMIA

BLOOD DISORDERS

BLOOD DISEASES

GENETIC FACTORS

HOSPITALS

PATIENTS

OMAN

Hypercholesterolemia

Acute Coronary Syndrome

Cardiovascular Abnormalities

Diabetes Mellitus

Arabs

Oman

Issues

Article Details

Authors: Al-Waili , Khalid | Al-Rasadi , Khalid | Zadjali , Fahad | Al-Hashmi , Khamis | Al-Mukhaini , Suad | Al-Kindi , Mohammed | Al-Sabti , Hilal | Al-Hinai , Ali Talib | Farhan , Hatem | Al-Zakwani , Ibrahim

Publisher: Oman Medical Specialty Board

Main Topics: Medicine

Journal: Oman Medical Journal 2020 Vol.35 Issue 3, pp.1-6

Document Type: Article

Publication Date: 5/2020

Document Language: English

Document ID (Org No.): 142276

Frequency: Bi-Monthly

eISSN: 20705204

pISSN: 1999768X

DOI: 10.5001/omj.2020.59

Descriptors:

Issues

Authors:

Al-Waili , Khalid | Al-Rasadi , Khalid | Zadjali , Fahad | Al-Hashmi , Khamis | Al-Mukhaini , Suad | Al-Kindi , Mohammed | Al-Sabti , Hilal | Al-Hinai , Ali Talib | Farhan , Hatem | Al-Zakwani , Ibrahim

Publisher:

Oman Medical Specialty Board

Main Topics:

Medicine

Journal:

Oman Medical Journal 2020 Vol.35 Issue 3, pp.1-6

Document Type:

Article

Publication Date:

5/2020

Document Language:

English

Document ID (Org No.):

142276

Frequency:

Bi-Monthly

eISSN:

20705204

pISSN:

1999768X

DOI:

10.5001/omj.2020.59