Effect of Sildenafil Citrate on Uterine Artery Blood Flow in Patients with Unexplained Recurrent Miscarriages : A Randomized Clinical Trial

Mohamed , Mohamed A.; Moussa , Assem A.; El-Taybe , Hazem M.

Article Details

Effect of Sildenafil Citrate on Uterine Artery Blood Flow in Patients with Unexplained Recurrent Miscarriages : A Randomized Clinical Trial

Authors:

Mohamed , Mohamed A. | Moussa , Assem A. | El-Taybe , Hazem M.

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2019 Vol.75 Issue 6, pp.2958-2964

Document Type:

Article

Publication Date:

4/2019

Document Language:

English

Document ID (Org No.):

136197

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

Descriptors:

Keywords:

Abstract:

 Background: Unexplained recurrent miscarriage can be a challenging and frustrating condition for bothpatients and clinicians. Sildenafil citrate is one of the currently available lines of treatment according tosimplicity of use, reliability and degree of invasiveness but up to now there are no prospective randomizedstudies, powerful enough. Aim of this Work: To evaluate the efficacy of oral sildenafil citrate 20 mg onuterine arteries Doppler flow studies in patients with unexplained recurrent miscarriages.Patients and Methods: This prospective case control study was conducted at Sayed Galal Maternity Hospitaloutpatient clinics on 180 women who' were divided into 2 groups: (group 1) which included 91 patients whotook sildenafil citrate 20 mg orally, 4 times per day for 21 days and (group 2) which included 89 patients whotook placebo orally, 4 times per day for 21 days in the period starting from (August 2017 to June 2018).Results: The statistical comparison between group I (sildenafil citrate) and group II (placebo) before and afteradministration of drug regarding endometrial thickness showed non-significant difference before andsignificant difference after 3 weeks of administration of sildenafil citrate in group I and placebo in group II. Thestatistical comparison in patients in group I (sildenafil citrate) before and after 1 week, 2 weeks and 3 weeksadministration of drug regarding pulsatility index, resistance index and systolic/diastolic ratio showedsignificant difference. Conclusion: Sildenafil citrate has an effective role in increasing the uterine arteriesblood flow in patients with recurrent miscarriage.

Article Details

Effect of Sildenafil Citrate on Uterine Artery Blood Flow in Patients with Unexplained Recurrent Miscarriages : A Randomized Clinical Trial

Authors:

Mohamed , Mohamed A. | Moussa , Assem A. | El-Taybe , Hazem M.

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2019 Vol.75 Issue 6, pp.2958-2964

Document Type:

Article

Publication Date:

4/2019

Document Language:

English

Document ID (Org No.):

136197

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

Descriptors:

MISCARRIAGE

UTERINE DISEASES

BLOOD FLOW

CITRATES

DRUG ACTION

OBSTETRICS

GYNECOLOGY

Sildenafil Citrate

Uterine Artery Blood Flow

Unexplained Recurrent Miscarriages

Issues

Article Details

Authors: Mohamed , Mohamed A. | Moussa , Assem A. | El-Taybe , Hazem M.

Publisher: Pan Arab League of Continuous Medical Education

Main Topics: Medicine

Journal: The Egyptian Journal of Hospital Medicine 2019 Vol.75 Issue 6, pp.2958-2964

Document Type: Article

Publication Date: 4/2019

Document Language: English

Document ID (Org No.): 136197

Frequency: Quarterly

eISSN: 20907125

pISSN: 16872002

Descriptors:

Issues

Authors:

Mohamed , Mohamed A. | Moussa , Assem A. | El-Taybe , Hazem M.

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2019 Vol.75 Issue 6, pp.2958-2964

Document Type:

Article

Publication Date:

4/2019

Document Language:

English

Document ID (Org No.):

136197

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002