Investigation of Serum Cathelicidin, Procalcitonin and Vitamin D Levels in Calves with Pneumonia

Cumali Özkan

Article Details

Investigation of Serum Cathelicidin, Procalcitonin and Vitamin D Levels in Calves with Pneumonia

Authors:

Cumali Özkan

Publisher:

Dicle University

Main Topics:

Veteriner Cerrahi

Journal:

Dicle Üniversitesi Veteriner Fakültesi Dergisi Vol.16 Issue 2, pp.65-70

Document Type:

Article

Publication Date:

12/2023

Document Language:

Turkish

Document ID (Org No.):

2001306558

pISSN:

1307-9972

Keywords:

Abstract:

 The purpose of this study was to determine the changes in serum cathelicidin, procalcitonin PCT, vitamin D and some other biochemical parameters in calves with pneumonia and to investigate the relationship between these parameters and the disease. The material of the study consisted of 40 calves, 30 of which comprised the disease group diagnosed with pneumonia and had different ages, breeds, and genders. Besides, 10 of these calves were healthy and comprised the control group. Clinical examination of the animals were performed and blood samples were obtained for hematological and biochemical analyses. Compared to the control, it was determined that body temperature and RBC values increased significantly in animals with pneumonia. Some hematological parameters such as hematocrit Hct, hemoglobin Hb, white blood cell count WBC, mean corpuscular hemoglobin MCH were high, while mean corpuscular volume MCV and thrombocyte count THR were found to be low, however, the changes in these parameters were not statistically significant. When compared to control group, serum cathelicidin, PCT and lactate dehydrogenase LDH levels were statistically higher p0.05, p0.05, p0.001, respectively. Vitamin D, calcium Ca, phosphorus P, magnesium Mg and alkalen phosphatase ALP levels were found to be low and vitamin D and P levels were statistically significant p0.05, p0.001, respectively. As a result, in calves with pneumonia; an increase in cathelicidin, PCT, and LDH, a decrease in vitamin D, Ca, Mg, P and ALP were detected. Therefore, associated with the calves with pneumonia; cathelicidin, PCT, vitamin D, and LDH levels had alterations. Furthermore, it was concluded that the addition of vitamin D, Ca, Mg, and P supplements to routine calves pneumonia treatments was thought to be beneficial in the progress of the disease.

 The purpose of this study was to determine the changes in serum cathelicidin, procalcitonin PCT, vitamin D and some other biochemical parameters in calves with pneumonia and to investigate the relationship between these parameters and the disease. The material of the study consisted of 40 calves, 30 of which comprised the disease group diagnosed with pneumonia and had different ages, breeds, and genders. Besides, 10 of these calves were healthy and comprised the control group. Clinical examination of the animals were performed and blood samples were obtained for hematological and biochemical analyses. Compared to the control, it was determined that body temperature and RBC values increased significantly in animals with pneumonia. Some hematological parameters such as hematocrit Hct, hemoglobin Hb, white blood cell count WBC, mean corpuscular hemoglobin MCH were high, while mean corpuscular volume MCV and thrombocyte count THR were found to be low, however, the changes in these parameters were not statistically significant. When compared to control group, serum cathelicidin, PCT and lactate dehydrogenase LDH levels were statistically higher p0.05, p0.05, p0.001, respectively. Vitamin D, calcium Ca, phosphorus P, magnesium Mg and alkalen phosphatase ALP levels were found to be low and vitamin D and P levels were statistically significant p0.05, p0.001, respectively. As a result, in calves with pneumonia; an increase in cathelicidin, PCT, and LDH, a decrease in vitamin D, Ca, Mg, P and ALP were detected. Therefore, associated with the calves with pneumonia; cathelicidin, PCT, vitamin D, and LDH levels had alterations. Furthermore, it was concluded that the addition of vitamin D, Ca, Mg, and P supplements to routine calves pneumonia treatments was thought to be beneficial in the progress of the disease.

 The purpose of this study was to determine the changes in serum cathelicidin, procalcitonin PCT, vitamin D and some other biochemical parameters in calves with pneumonia and to investigate the relationship between these parameters and the disease. The material of the study consisted of 40 calves, 30 of which comprised the disease group diagnosed with pneumonia and had different ages, breeds, and genders. Besides, 10 of these calves were healthy and comprised the control group. Clinical examination of the animals were performed and blood samples were obtained for hematological and biochemical analyses. Compared to the control, it was determined that body temperature and RBC values increased significantly in animals with pneumonia. Some hematological parameters such as hematocrit Hct, hemoglobin Hb, white blood cell count WBC, mean corpuscular hemoglobin MCH were high, while mean corpuscular volume MCV and thrombocyte count THR were found to be low, however, the changes in these parameters were not statistically significant. When compared to control group, serum cathelicidin, PCT and lactate dehydrogenase LDH levels were statistically higher p0.05, p0.05, p0.001, respectively. Vitamin D, calcium Ca, phosphorus P, magnesium Mg and alkalen phosphatase ALP levels were found to be low and vitamin D and P levels were statistically significant p0.05, p0.001, respectively. As a result, in calves with pneumonia; an increase in cathelicidin, PCT, and LDH, a decrease in vitamin D, Ca, Mg, P and ALP were detected. Therefore, associated with the calves with pneumonia; cathelicidin, PCT, vitamin D, and LDH levels had alterations. Furthermore, it was concluded that the addition of vitamin D, Ca, Mg, and P supplements to routine calves pneumonia treatments was thought to be beneficial in the progress of the disease.

 Bu çalışmada; pnömoni tanısı konan buzağılarda serum katelisidin, prokalsitonin PCT, D vitamini ve bazı biyokimyasal parametre düzeylerindeki değişimlerin belirlenmesi ve bu parametrelerin hastalıkla olan ilişkilerinin araştırılması amaçlanmıştır. Pnömoni teşhisi konulan, farklı yaş, ırk ve cinsiyette 30 adet hasta buzağı Hasta grubu ile 10 adet sağlıklı buzağı Kontrol grubu olmak üzere toplam 40 adet buzağı çalışma materyalini oluşturdu. Hayvanların genel klinik muayeneleri yapılarak hematolojik ve biyokimyasal analizler için kan örnekleri alındı. Kontrol grubundaki hayvanlara göre; hasta grubundaki hayvanlarda vücut sıcaklığı ve total eritrosit sayısı RBC değerlerinin istatistiksel olarak artış gösterdiği, bazı hematolojik Hematokrit Hct, hemoglobin Hb, total lökosit sayısı WBC, ortalama eritrosit hemoglobini MCH ve ortalama eritrosit hemoglobin oranı MCHC parametre değerlerinin yüksek, bazılarının ortalama eritrosit hacmi MCV ve trombosit sayısı THR ise düşük olduğu, ancak bu parametrelerdeki değişimlerin istatistiksel olarak anlamlı olmadığı tespit edildi. Kontrol grubu hayvanlara göre; hasta grubu hayvanlarda serum katelisidin, prokalsitonin ve laktat dehidrogenaz LDH değerlerinin istatistiksel olarak artış gösterdiği belirlendi sırasıyla p0.05, p0.05, p0.001. D vitamini, kalsiyum Ca, fosfor P, magnezyum Mg ve alkalen fosfataz ALP değerlerinin ise daha düşük olduğu, bu değerlerden D vitamini ve Pun istatistiksel olarak anlamlı olduğu sırasıyla p0.05, p0.001, diğer parametrelerde ise anlamlı bir farkın olmadığı tespit edildi p0.05. Sonuç olarak; bu çalışmada pnömonili buzağılarda katelisidin, PCT ve LDH düzeylerinde artış, D vitamini, Ca, Mg, P ve ALP seviyelerinde ise azalma olduğu belirlendi. Böylece pnömonili buzağılarda hastalıkla ilişkili olarak; katelisidin, PCT, D vitamini ve LDH düzeylerinde değişimler olduğu, pnömonili buzağılarda rutin tedavilere ek olarak D vitamini, Ca, Mg ve P takviyelerinin yapılmasının hastalığın seyrinde yararlı olabileceği kanısına varılmıştır.

Article Details

Investigation of Serum Cathelicidin, Procalcitonin and Vitamin D Levels in Calves with Pneumonia

Authors:

Cumali Özkan

Publisher:

Dicle University

Main Topics:

Veteriner Cerrahi

Journal:

Dicle Üniversitesi Veteriner Fakültesi Dergisi Vol.16 Issue 2, pp.65-70

Document Type:

Article

Publication Date:

12/2023

Document Language:

Turkish

Document ID (Org No.):

2001306558

pISSN:

1307-9972

Calf

Vitamin D

Cathelicidin

Pneumonia

ProcalcitoninBuzağı

D vitamini

Katelisidin

Pnömoni

Prokalsitonin

Issues

Article Details

Authors: Cumali Özkan

Publisher: Dicle University

Main Topics: Veteriner Cerrahi

Journal: Dicle Üniversitesi Veteriner Fakültesi Dergisi Vol.16 Issue 2, pp.65-70

Document Type: Article

Publication Date: 12/2023

Document Language: Turkish

Document ID (Org No.): 2001306558

pISSN: 1307-9972

Issues

Authors:

Cumali Özkan

Publisher:

Dicle University

Main Topics:

Veteriner Cerrahi

Journal:

Dicle Üniversitesi Veteriner Fakültesi Dergisi Vol.16 Issue 2, pp.65-70

Document Type:

Article

Publication Date:

12/2023

Document Language:

Turkish

Document ID (Org No.):

2001306558

pISSN:

1307-9972