Preventing cisplatin induced ototoxicity by  N-acetylcysteine and salicylate

Müzeyyen YILDIRIM; Hasan Mete İNANÇLI; Baver SAMANCI; Mehmet Faruk OKTAY; Murat ENÖZ; İsmail TOPÇU

Article Details

Preventing cisplatin induced ototoxicity by N-acetylcysteine and salicylate

Authors:

Müzeyyen YILDIRIM | Hasan Mete İNANÇLI | Baver SAMANCI | Mehmet Faruk OKTAY | Murat ENÖZ | İsmail TOPÇU

Publisher:

Istanbul University

Journal:

The Turkish Journal of Ear Nose and Throat 2010 Vol.20 Issue 4, pp.173-183

Document Type:

Article

Publication Date:

8/2010

Document Language:

English

Document ID (Org No.):

2000807275

Frequency:

Quarterly

eISSN:

2602-4837

Keywords:

Abstract:

 

Objectives: In this study we investigated if CP induced ototoxicity could be prevented or reduced by the use of salicylate and N-acetylcysteine. Patients and Methods: Fifty-four patients  28 females, 26 males; mean age 37±9.5 years; range 29 to 71 years  who had cisplatin chemotherapy due to solid organ tumors were enrolled in the study. The patients were randomized into three groups, with 18 patients in each group. The first group  control group  received cisplatin, second group received N-acetylcysteine  NAC; 600 mg/day  with cisplatin and the third group received salicylate  300 mg/day  with cisplatin. All patients evaluated audiologically including high frequency audiometry and auditory brainstem response. Results: The cisplatin-induced ototoxic damage could be reduced in 10,000 and 12,000 Hz frequencies when N-acetylcysteine was added to the cisplatin therapy protocol. There was no decrease in the hearing loss levels of the patients who were receiving cisplatin with salicylate. Conclusion: According to auditory brainstem response testing results, there was no difference detected between N-acetylcysteine or salicylate for the amelioration of cisplatin induced ototoxicity.

 

Amaç: Bu çalışmada salisilat ve N-asetilsistein kullanımıyla cisplatin kaynaklı ototoksisitenin azaltılabilirliği ya da engellenebilirliği araştırıldı.Hastalar ve Yöntemler: Solid organ tümörü nedeniyle cisplatin kemoterapi kullanan 54 hasta  28 kadın, 26 erkek; ort. yaş 37±9.5; dağılım 29-71 yıl  çalışmaya dahil edildi. Hastalar her bir grupta 18 kişi olacak şekilde rastgele üç gruba ayrıldı. İlk grup  kontrol grubu  sadece cisplatin aldı, ikinci grup N-acetylcysteine  NAC; 600 mg/gün  ile birlikte cisplatin aldı ve üçüncü grup salisilat  300 mg/gün  ile birlikte cisplatin aldı. Bütün hastalar yüksek frekans odyometri ve işitsel beyin sapı yanıtını içeren odyolojik incelemeyle değerlendirildi.Bulgular: Cisplatin tedavi protokolüne N-asetilsisteine eklenmesiyle, 10.000 ve 12.000 Hz frekanslarındaki cisplatin kaynaklı ototoksik hasarın azaldığı görüldü. Cisplatine ile salisilat alan hastaların işitme kayıbı seviyelerinde herhangi bir azalma görülmedi.Sonuç: Çalışmamızda işitsel beyin sapı yanıtı testi sonuçlarına bakıldığında ne N-asetilsistein ne de salisilat alan hastalar arasında cisplatin ototoksisitesini azaltma yönünden anlamlı fark bulundu.

Article Details

Preventing cisplatin induced ototoxicity by N-acetylcysteine and salicylate

Authors:

Müzeyyen YILDIRIM | Hasan Mete İNANÇLI | Baver SAMANCI | Mehmet Faruk OKTAY | Murat ENÖZ | İsmail TOPÇU

Publisher:

Istanbul University

Journal:

The Turkish Journal of Ear Nose and Throat 2010 Vol.20 Issue 4, pp.173-183

Document Type:

Article

Publication Date:

8/2010

Document Language:

English

Document ID (Org No.):

2000807275

Frequency:

Quarterly

eISSN:

2602-4837

Cisplatin

N-asetilsistein

ototoksisite

salisilat.

Issues

Article Details

Preventing cisplatin induced ototoxicity by N-acetylcysteine and salicylate

Authors: Müzeyyen YILDIRIM | Hasan Mete İNANÇLI | Baver SAMANCI | Mehmet Faruk OKTAY | Murat ENÖZ | İsmail TOPÇU

Publisher: Istanbul University

Journal: The Turkish Journal of Ear Nose and Throat 2010 Vol.20 Issue 4, pp.173-183

Document Type: Article

Publication Date: 8/2010

Document Language: English

Document ID (Org No.): 2000807275

Frequency: Quarterly

eISSN: 2602-4837

Cisplatin

N-asetilsistein

ototoksisite

salisilat.

Issues

Authors:

Müzeyyen YILDIRIM | Hasan Mete İNANÇLI | Baver SAMANCI | Mehmet Faruk OKTAY | Murat ENÖZ | İsmail TOPÇU

Publisher:

Istanbul University

Journal:

The Turkish Journal of Ear Nose and Throat 2010 Vol.20 Issue 4, pp.173-183

Document Type:

Article

Publication Date:

8/2010

Document Language:

English

Document ID (Org No.):

2000807275

Frequency:

Quarterly

eISSN:

2602-4837