Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) as Donor Ligands in Organotin(IV) Derivatives: Synthesis, Spectroscopic Characterization and Biological Applications

Saira SHAHZADI; Khadija SHAHID

Article Details

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) as Donor Ligands in Organotin(IV) Derivatives: Synthesis, Spectroscopic Characterization and Biological Applications

Authors:

Saira SHAHZADI | Khadija SHAHID

Publisher:

TUBITAK

Journal:

Turkish Journal of Chemistry 2005 Vol.29 Issue 3, pp.273-288

Document Type:

Article

Publication Date:

2/2005

Document Language:

Turkish

Document ID (Org No.):

2000729098

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527

Abstract:

 

Some new di- and tri-organotin(IV) derivatives of 4  different non-steroidal anti-inflammatory drugs (NSAIDs) with the  general formulae R2SnL2 and R3SnL (where R = n-C8H17 and  C6H5CH2) and L = 2-[(2,3-dimethylphenyl)amino]benzoic acid,  2-(2-fluoro-4-biphenyl)propionic acid, 2-(4-isobutylphenyl) propionic  acid and 2-(3-benzoylphenyl)-propionic acid were synthesized.  These  compounds were structurally characterized by infrared and multinuclear  NMR (1H, 13C, 119Sn) spectroscopies and mass spectrometry.  The  isotopic effect of tin was studied by comparison of experimental data  with the simulated isotopic pattern using the Chemtool software  package.  These compounds were also screened against different animal  and plant pathogens to study their biological activity.  LD50 data  show that the reported compounds have significant toxicity.

 

Some new di- and tri-organotin(IV) derivatives of 4  different non-steroidal anti-inflammatory drugs (NSAIDs) with the  general formulae R2SnL2 and R3SnL (where R = n-C8H17 and  C6H5CH2) and L = 2-[(2,3-dimethylphenyl)amino]benzoic acid,  2-(2-fluoro-4-biphenyl)propionic acid, 2-(4-isobutylphenyl) propionic  acid and 2-(3-benzoylphenyl)-propionic acid were synthesized.  These  compounds were structurally characterized by infrared and multinuclear  NMR (1H, 13C, 119Sn) spectroscopies and mass spectrometry.  The  isotopic effect of tin was studied by comparison of experimental data  with the simulated isotopic pattern using the Chemtool software  package.  These compounds were also screened against different animal  and plant pathogens to study their biological activity.  LD50 data  show that the reported compounds have significant toxicity.

Article Details

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) as Donor Ligands in Organotin(IV) Derivatives: Synthesis, Spectroscopic Characterization and Biological Applications

Authors: Saira SHAHZADI | Khadija SHAHID

Publisher: TUBITAK

Journal: Turkish Journal of Chemistry 2005 Vol.29 Issue 3, pp.273-288

Document Type: Article

Publication Date: 2/2005

Document Language: Turkish

Document ID (Org No.): 2000729098

Frequency: Bimonthly

eISSN: 1303-6130

pISSN: 1300-0527

Issues

Authors:

Saira SHAHZADI | Khadija SHAHID

Publisher:

TUBITAK

Journal:

Turkish Journal of Chemistry 2005 Vol.29 Issue 3, pp.273-288

Document Type:

Article

Publication Date:

2/2005

Document Language:

Turkish

Document ID (Org No.):

2000729098

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527