Preliminary studies on antiin!ammatory, antipyretic, and antidiarrhoeal properties of Evolvulus alsinoides

U. M. Dhana LEKSHMI; P. Neelakanta REDDY

Article Details

Preliminary studies on antiin!ammatory, antipyretic, and antidiarrhoeal properties of Evolvulus alsinoides

Authors:

U. M. Dhana LEKSHMI | P. Neelakanta REDDY

Publisher:

TUBITAK

Main Topics:

Life sciences

Journal:

Turkish Journal of Biology 2011 Vol.35 Issue 5, pp.611-618

Document Type:

Article

Publication Date:

4/2011

Document Language:

English

Document ID (Org No.):

2000812799

Frequency:

Bimonthly

eISSN:

1303-6092

pISSN:

1300-0152

Keywords:

Abstract:

 

The ethanolic extract of the whole plant of Evolvulus alsinoides L. (Convolvulaceae) was investigated for antiinflammatory, antipyretic and antidiarrhoeal properties in female albino rats. Preliminary phytochemical studies were carried out to confirm the presence of active chemical constituents in the plant extract, and the result showed a positive report for the presence of flavonoids, alkaloids and cardiac glycosides. The pharmacological result showed that the ethanolic extract at a dose of 250 mg/kg body weight and 500 mg/kg body weight caused a significant (P < 0.05) inhibition of the carrageenan-induced rat paw oedema and a significant (P < 0.05) reduction of hyperpyrexia induced  by Brewer's yeast in rats. The extract also elicited marked antidiarrhoeal activity against castor oil-induced diarrhoea at a dose of 500 mg/kg. This study has proved scientifically the ancient claim that the whole plant of Evolvulus alsinoides has antiinflammatory, antipyretic and antidiarrhoeal activities.

 

The ethanolic extract of the whole plant of Evolvulus alsinoides L. (Convolvulaceae) was investigated for antiinflammatory, antipyretic and antidiarrhoeal properties in female albino rats. Preliminary phytochemical studies were carried out to confirm the presence of active chemical constituents in the plant extract, and the result showed a positive report for the presence of flavonoids, alkaloids and cardiac glycosides. The pharmacological result showed that the ethanolic extract at a dose of 250 mg/kg body weight and 500 mg/kg body weight caused a significant (P < 0.05) inhibition of the carrageenan-induced rat paw oedema and a significant (P < 0.05) reduction of hyperpyrexia induced  by Brewer's yeast in rats. The extract also elicited marked antidiarrhoeal activity against castor oil-induced diarrhoea at a dose of 500 mg/kg. This study has proved scientifically the ancient claim that the whole plant of Evolvulus alsinoides has antiinflammatory, antipyretic and antidiarrhoeal activities.

Article Details

Preliminary studies on antiin!ammatory, antipyretic, and antidiarrhoeal properties of Evolvulus alsinoides

Authors:

U. M. Dhana LEKSHMI | P. Neelakanta REDDY

Publisher:

TUBITAK

Main Topics:

Life sciences

Journal:

Turkish Journal of Biology 2011 Vol.35 Issue 5, pp.611-618

Document Type:

Article

Publication Date:

4/2011

Document Language:

English

Document ID (Org No.):

2000812799

Frequency:

Bimonthly

eISSN:

1303-6092

pISSN:

1300-0152

Key words: Evolvulus alsinoides

antiinflammatory

antipyretic

antidiarrhoeal

rats

carrageenan

brewer's yeast

castor oil

Issues

Article Details

Authors: U. M. Dhana LEKSHMI | P. Neelakanta REDDY

Publisher: TUBITAK

Main Topics: Life sciences

Journal: Turkish Journal of Biology 2011 Vol.35 Issue 5, pp.611-618

Document Type: Article

Publication Date: 4/2011

Document Language: English

Document ID (Org No.): 2000812799

Frequency: Bimonthly

eISSN: 1303-6092

pISSN: 1300-0152

Issues

Authors:

U. M. Dhana LEKSHMI | P. Neelakanta REDDY

Publisher:

TUBITAK

Main Topics:

Life sciences

Journal:

Turkish Journal of Biology 2011 Vol.35 Issue 5, pp.611-618

Document Type:

Article

Publication Date:

4/2011

Document Language:

English

Document ID (Org No.):

2000812799

Frequency:

Bimonthly

eISSN:

1303-6092

pISSN:

1300-0152