Clinical, histopathological features and malignancy frequency of patients with idiopathic inflammatory myopathy

Elif Altunel Kılınç; Zeynep Tüzün; Gizem Kırmızıer; Gizem Varkal; İpek Türk; Didem Arslan; Hüseyin Turgut Elbek Özer; Süleyman Özbek

Article Details

Clinical, histopathological features and malignancy frequency of patients with idiopathic inflammatory myopathy

Authors:

Elif Altunel Kılınç | Zeynep Tüzün | Gizem Kırmızıer | Gizem Varkal | İpek Türk | Didem Arslan | Hüseyin Turgut Elbek Özer | Süleyman Özbek

Publisher:

Cukurova University

Main Topics:

Romatoloji ve Artrit

Journal:

Cukurova Medical Journal Vol.49 Issue 2, pp.314-319

Document Type:

Article

Publication Date:

6/2024

Document Language:

English

Document ID (Org No.):

2001320785

pISSN:

2602-3032

Keywords:

Abstract:

 Purpose: Idiopathic inflammatory myopathy IIM group diseases are strongly linked to cancer. This study aims to describe the clinical and histopathological features of IIM patients diagnosed in our clinic, evaluate the frequency and subtypes of accompanying malignancies, and examine the relationship between pathological staining patterns and IIM subgroups. Materials and Methods: This retrospective study included 74 patients with IIM diagnosed between 2010 and 2023 who had a muscle biopsy at the time of diagnosis. Age, gender, imaging, electromyography, and muscle biopsy results were obtained using the hospitals electronic system. Results: Of the 74 patients with IIM, 45 are polymyositis PM, 27 are dermatomyositis DM and two are inclusion body myositis IBM. Malignancy developed in 12 16 of 74 IIMs, two 16.6 of whom had malignancy before the diagnosis of IIM one breast cancer, one thyroid papillary cancer. Malignancy was diagnosed in five patients 41.6 in the PM group the most common breast cancer, five patients 41.6 in the DM group the most common endometrial cancer, and two patients 16.8 in the IBM group. It was found that positive staining with membrane attack complex was higher in the DM group compared to the PM group. Conclusion: Cancer screening should be performed at regular intervals in IIM patients. Breast and endometrial cancer screening should be prioritized in female patients, as well as lung cancer screening in male patients. Large cohort studies are needed to explain the relationship between pathological staining patterns and IIM subtypes.

 Purpose: Idiopathic inflammatory myopathy IIM group diseases are strongly linked to cancer. This study aims to describe the clinical and histopathological features of IIM patients diagnosed in our clinic, evaluate the frequency and subtypes of accompanying malignancies, and examine the relationship between pathological staining patterns and IIM subgroups. Materials and Methods: This retrospective study included 74 patients with IIM diagnosed between 2010 and 2023 who had a muscle biopsy at the time of diagnosis. Age, gender, imaging, electromyography, and muscle biopsy results were obtained using the hospitals electronic system. Results: Of the 74 patients with IIM, 45 are polymyositis PM, 27 are dermatomyositis DM and two are inclusion body myositis IBM. Malignancy developed in 12 16 of 74 IIMs, two 16.6 of whom had malignancy before the diagnosis of IIM one breast cancer, one thyroid papillary cancer. Malignancy was diagnosed in five patients 41.6 in the PM group the most common breast cancer, five patients 41.6 in the DM group the most common endometrial cancer, and two patients 16.8 in the IBM group. It was found that positive staining with membrane attack complex was higher in the DM group compared to the PM group. Conclusion: Cancer screening should be performed at regular intervals in IIM patients. Breast and endometrial cancer screening should be prioritized in female patients, as well as lung cancer screening in male patients. Large cohort studies are needed to explain the relationship between pathological staining patterns and IIM subtypes.

 Purpose: Idiopathic inflammatory myopathy IIM group diseases are strongly linked to cancer. This study aims to describe the clinical and histopathological features of IIM patients diagnosed in our clinic, evaluate the frequency and subtypes of accompanying malignancies, and examine the relationship between pathological staining patterns and IIM subgroups. Materials and Methods: This retrospective study included 74 patients with IIM diagnosed between 2010 and 2023 who had a muscle biopsy at the time of diagnosis. Age, gender, imaging, electromyography, and muscle biopsy results were obtained using the hospitals electronic system. Results: Of the 74 patients with IIM, 45 are polymyositis PM, 27 are dermatomyositis DM and two are inclusion body myositis IBM. Malignancy developed in 12 16 of 74 IIMs, two 16.6 of whom had malignancy before the diagnosis of IIM one breast cancer, one thyroid papillary cancer. Malignancy was diagnosed in five patients 41.6 in the PM group the most common breast cancer, five patients 41.6 in the DM group the most common endometrial cancer, and two patients 16.8 in the IBM group. It was found that positive staining with membrane attack complex was higher in the DM group compared to the PM group. Conclusion: Cancer screening should be performed at regular intervals in IIM patients. Breast and endometrial cancer screening should be prioritized in female patients, as well as lung cancer screening in male patients. Large cohort studies are needed to explain the relationship between pathological staining patterns and IIM subtypes.

 Amaç: İdiyopatik inflamatuar miyopati İİM grubu hastalıklar kanser ile güçlü bir şekilde ilişkilidir. Bu çalışmada kliniğimizde tanı konulan İİM hastalarının klinik ve histopatolojik özelliklerinin tanımlanması, eşlik eden malignitelerin sıklığı ve alt tiplerinin değerlendirilmesi ve patolojik boyanma paternleri ile İİM alt grupları arasındaki ilişkiyi incelemektir. Gereç ve Yöntem: Bu retrospektif çalışmaya 2010-2023 yılları arasında İİM tanısı konan ve tanı anında kas biyopsisi yapılan 74 hasta dahil edilmiştir. Yaş, cinsiyet, görüntüleme, elektromiyografi ve kas biyopsisi sonuçları hastanenin elektronik sistemi kullanılarak elde edildi. Bulgular: İİMli 74 hastanın 45i polimiyozit PM, 27si dermatomiyozit DM ve ikisi inklüzyon cisimciği miyozitidir İCM. İİMli 74 hastanın 12sinde 16 malignite gelişti, bunların ikisinde 16,6 İİM tanısından önce malignite vardı bir meme kanseri, bir tiroid papiller kanseri. PM grubunda beş hastada 41,6 en sık meme kanseri, DM grubunda beş hastada 41,6 en sık endometriyal kanser ve İCM grubunda iki hastada 16,8 malignite tanısı konmuştur. Membran atak kompleksi ile pozitif boyanmanın DM grubunda PM grubuna kıyasla daha yüksek olduğu bulunmuştur. Sonuç: Bu sonuçlar, İİM hastalarında kanser taramasının düzenli aralıklarla yapılması gerektiğini göstermektedir. Kadın hastalarda meme ve endometriyal kanser taramasına ve erkek hastalarda akciğer kanseri taramasına özel önem verilmelidir. Patolojik boyama modelleri ile İİM alt tipleri arasındaki ilişkiyi açıklamak için geniş kohort çalışmalarına ihtiyaç vardır.

Article Details

Clinical, histopathological features and malignancy frequency of patients with idiopathic inflammatory myopathy

Authors:

Elif Altunel Kılınç | Zeynep Tüzün | Gizem Kırmızıer | Gizem Varkal | İpek Türk | Didem Arslan | Hüseyin Turgut Elbek Özer | Süleyman Özbek

Publisher:

Cukurova University

Main Topics:

Romatoloji ve Artrit

Journal:

Cukurova Medical Journal Vol.49 Issue 2, pp.314-319

Document Type:

Article

Publication Date:

6/2024

Document Language:

English

Document ID (Org No.):

2001320785

pISSN:

2602-3032

polymyositis

dermatomyositis

inclusion body myositis

membrane attack complex

malignancyPolimiyozit

dermatomiyozit

inklüzyon cisimcikli miyozit

membran atak kompleksi

malignite

Issues

Article Details

Authors: Elif Altunel Kılınç | Zeynep Tüzün | Gizem Kırmızıer | Gizem Varkal | İpek Türk | Didem Arslan | Hüseyin Turgut Elbek Özer | Süleyman Özbek

Publisher: Cukurova University

Main Topics: Romatoloji ve Artrit

Journal: Cukurova Medical Journal Vol.49 Issue 2, pp.314-319

Document Type: Article

Publication Date: 6/2024

Document Language: English

Document ID (Org No.): 2001320785

pISSN: 2602-3032

Issues

Authors:

Elif Altunel Kılınç | Zeynep Tüzün | Gizem Kırmızıer | Gizem Varkal | İpek Türk | Didem Arslan | Hüseyin Turgut Elbek Özer | Süleyman Özbek

Publisher:

Cukurova University

Main Topics:

Romatoloji ve Artrit

Journal:

Cukurova Medical Journal Vol.49 Issue 2, pp.314-319

Document Type:

Article

Publication Date:

6/2024

Document Language:

English

Document ID (Org No.):

2001320785

pISSN:

2602-3032