Relationship of multiple myeloma with ABO blood groups

Didar YANARDAĞ AÇIK; Mehmet BANKİR; Begüm Seyda AVCİ

doi:https://doi.org/10.19161/etd.990715

Article Details

Relationship of multiple myeloma with ABO blood groups

Authors:

Didar YANARDAĞ AÇIK | Mehmet BANKİR | Begüm Seyda AVCİ

Main Topics:

Promotion of health

Journal:

Ege Journal of Medicine 2021 Vol.60 Issue 3, pp.274-280

Document Type:

Article

Publication Date:

9/2021

Document Language:

English

Document ID (Org No.):

2000953549

DOI:

https://doi.org/10.19161/etd.990715

Keywords:

Abstract:

 

Aim: Multiple myeloma is a heterogeneous, incurable haematological cancer that occurs as a result of the clonal proliferation of plasma cells. The impact of blood groups on human diseases and/or their role in the prognosis of the disease has attracted the attention of scientists since the discovery of blood groups. We investigated the blood group distribution of multiple myeloma patients and whether their blood groups are related to immunoglobulin type.
Materials and Methods: 75 multiple myeloma patients and 73128 control group were included in the study, which was planned retrospectively. The statistical evaluation was performed by using Statistical Package for Social Sciences (SPSS) software for Windows 20 (IBM SPSS Inc., Chicago, IL). The normal distribution of the data was evaluated with the Kolmogorov-Smirnov test.
Results: In multiple myeloma patients, the rate of A and B blood groups was low, and the rate of O and AB blood groups was high. Heavy chain IgA ratio was higher in B blood group compared to other blood groups. On the other hand, IgG ratio was found higher in O blood group compared to other blood groups.
Conclusion: A relationship has been found between immunoglobulin type and blood types in multiple myeloma. More comprehensive studies are needed on this subject.

 

Amaç: Multipl myelom plazma hücrelerinin klonal proliferasyonu sonucu oluşan, heterojen, kür sağlanamayan hematolojik bir kanserdir. Kan gruplarının insan hastalıklarına katkısı ve/veya hastalık seyrindeki rolü kan gruplarının keşfinden bu yana bilim insanlarının ilgisini çekmiştir. Multipl myelom hastalarının kan grubu dağılımını ve kan gruplarının immunglobulin tipi ile ilişkisinin olup olmadığını araştırdık.
Gereç ve Yöntem: Retrospektif planlanan çalışmaya 75 multipl myelom hastası ve 73128 kontrol grubu dahil edildi. İstatistiksel değerlendirme Statistical Package for Social Sciences (SPSS) for Windows 20 (IBM SPSS Inc., Chicago, IL) programı kullanılarak yapıldı. Verilerin normal dağılımı Kolmogorov-Smirnov testi ile değerlendirildi.
Bulgular: Multipl myelom hastalarında A ve B kan grupları oranı düşük, O ve AB kan grupları oranı yüksek saptandı. B kan grubunda ağır zincir IgA oranı diğer kan gruplarına kıyasla daha yüksek saptandı. IgG oranı ise O kan grubunda diğer kan gruplarına kıyasla daha yüksek saptandı.
Sonuç: Multipl myelomda immunoglobulin tipi ile kan grupları arasında bir ilişki bulunmuştur. Bu konuda yapılacak daha kapsamlı çalışmalara ihtiyaç vardır.

Article Details

Relationship of multiple myeloma with ABO blood groups

Authors:

Didar YANARDAĞ AÇIK | Mehmet BANKİR | Begüm Seyda AVCİ

Main Topics:

Promotion of health

Journal:

Ege Journal of Medicine 2021 Vol.60 Issue 3, pp.274-280

Document Type:

Article

Publication Date:

9/2021

Document Language:

English

Document ID (Org No.):

2000953549

DOI:

https://doi.org/10.19161/etd.990715

Multipl myelom

ABO kan grubu

monoklonal gammopati

Issues

Article Details

Relationship of multiple myeloma with ABO blood groups

Authors: Didar YANARDAĞ AÇIK | Mehmet BANKİR | Begüm Seyda AVCİ

Main Topics: Promotion of health

Journal: Ege Journal of Medicine 2021 Vol.60 Issue 3, pp.274-280

Document Type: Article

Publication Date: 9/2021

Document Language: English

Document ID (Org No.): 2000953549

DOI: https://doi.org/10.19161/etd.990715

Multipl myelom

ABO kan grubu

monoklonal gammopati

Issues

Authors:

Didar YANARDAĞ AÇIK | Mehmet BANKİR | Begüm Seyda AVCİ

Main Topics:

Promotion of health

Journal:

Ege Journal of Medicine 2021 Vol.60 Issue 3, pp.274-280

Document Type:

Article

Publication Date:

9/2021

Document Language:

English

Document ID (Org No.):

2000953549

DOI:

https://doi.org/10.19161/etd.990715