Synthesis and biological evaluation of quinoline-triazole and quinolone-triazole conjugates

Ayşegül GÜMÜŞ; Veysi OKUMUŞ

Article Details

Synthesis and biological evaluation of quinoline-triazole and quinolone-triazole conjugates

Authors:

Ayşegül GÜMÜŞ | Veysi OKUMUŞ

Publisher:

TUBITAK

Main Topics:

Applied physics

Journal:

Turkish Journal of Chemistry 2018 Vol.42 Issue 5, pp.1344-1357

Document Type:

Article

Publication Date:

10/2018

Document Language:

English

Document ID (Org No.):

2000726004

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527

Abstract:

 


 
                         One-pot synthesis of novel quinoline- and quinolone-substituted 
1,2,3-triazoles has been performed from the key intermediates, quinoline- 
and quinolone-substituted propargyl derivatives 1-3 
(48%-88% yields). The antioxidant properties of the newly synthesized 
compounds, 1a-1c, 2a-2c, and 3a-3c, were evaluated by monitoring DPPH 
(2,2-diphenyl-1-picrylhydrazyl) radical scavenging abilities, metal 
chelating effects, and reducing power. The scavenging effects of compounds 
on the free radical decreased in the order of 3b> >  >>> 3a> >  >>>
1b} and were found to be 36.3%, 34.9%, and 27.6% at the 
concentration of 500 μ μ  μμ\mu g/mL, respectively. All of the compounds showed 
low chelating capacity. Furthermore, the antibacterial activity was studied 
against gram-positive and gram-negative bacteria and the DNA binding ability 
of the compounds was evaluated with calf thymus DNA using agarose gel 
electrophoresis.
                    

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Article Details

Synthesis and biological evaluation of quinoline-triazole and quinolone-triazole conjugates

Authors: Ayşegül GÜMÜŞ | Veysi OKUMUŞ

Publisher: TUBITAK

Main Topics: Applied physics

Journal: Turkish Journal of Chemistry 2018 Vol.42 Issue 5, pp.1344-1357

Document Type: Article

Publication Date: 10/2018

Document Language: English

Document ID (Org No.): 2000726004

Frequency: Bimonthly

eISSN: 1303-6130

pISSN: 1300-0527

Issues

Authors:

Ayşegül GÜMÜŞ | Veysi OKUMUŞ

Publisher:

TUBITAK

Main Topics:

Applied physics

Journal:

Turkish Journal of Chemistry 2018 Vol.42 Issue 5, pp.1344-1357

Document Type:

Article

Publication Date:

10/2018

Document Language:

English

Document ID (Org No.):

2000726004

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527