No Association Between IRS2 Gly1057Asp Polymorphism and Esophageal Cancer

İsmail GÜLAÇAR; Zehra KAYA; Necat ALMALI; Can ATEŞ; Gözde YEŞİL SAYIN; Gökhan GÖRGİŞEN

doi:https://doi.org/10.52976/vansaglik.933072

Article Details

No Association Between IRS2 Gly1057Asp Polymorphism and Esophageal Cancer

Authors:

İsmail GÜLAÇAR | Zehra KAYA | Necat ALMALI | Can ATEŞ | Gözde YEŞİL SAYIN | Gökhan GÖRGİŞEN

Publisher:

Van Yuzuncu Yıl University

Main Topics:

Diseases

Journal:

Van Health Sciences Journal 2021 Vol.14 Issue 3, pp.298-303

Document Type:

Article

Publication Date:

12/2021

Document Language:

English

Document ID (Org No.):

2000679809

Frequency:

Tri-annual

eISSN:

2667-5072

pISSN:

2667-5072

DOI:

https://doi.org/10.52976/vansaglik.933072

Abstract:

 

Introduction: The aim of this study was to figure out the relationship between IRS2 Gly1057Asp variant and susceptibility to esophageal cancer.
Material and Methods: A case-control study was conducted to select 70 esophageal cancer patients and 100 healthy control samples. Genomic DNA was extracted from peripheral whole blood samples and real time polymerase chain reaction (RT-PCR) based SNP genotyping was performed using predesigned Taqman assay. 
Results: There was no significant difference in the frequency distribution of genotypes between patients and control group.
Conclusion: There is no significant correlation between the IRS2 Gly1057Asp variant and the risk of esophageal cancer.

 

Amaç: Bu çalışmanın amacı IRS2 Gly1057Asp varyantı ile özofagus kanseri yatkınlığı arasındaki ilişkiyi ortaya çıkarmaktır. 
Materyal ve Metod: Çalışma 70 özofagus kanseri ve 100 sağlıklı kontrol örneğini içeren vaka-kontrol çalışmasıdır. Genomik DNA, periferal kandan izole edilmiş olup, gerçek zamanlı polimeraz zincir reaksiyonu (RT-PCR) temelli SNP genotipleme için ticari olarak dizayn edilmiş Taqman assay kullanılmıştır.
Bulgular: Genotip dağılımında hasta ve kontrol örnekler arasında anlamlı bir farklılık saptanmamıştır.
Sonuç: IRS2 Gly1057Asp varyantı ile özofagus kanser gelişim riski arasında anlamlı bir ilişki belirlenememiştir.

Article Details

No Association Between IRS2 Gly1057Asp Polymorphism and Esophageal Cancer

Authors: İsmail GÜLAÇAR | Zehra KAYA | Necat ALMALI | Can ATEŞ | Gözde YEŞİL SAYIN | Gökhan GÖRGİŞEN

Publisher: Van Yuzuncu Yıl University

Main Topics: Diseases

Journal: Van Health Sciences Journal 2021 Vol.14 Issue 3, pp.298-303

Document Type: Article

Publication Date: 12/2021

Document Language: English

Document ID (Org No.): 2000679809

Frequency: Tri-annual

eISSN: 2667-5072

pISSN: 2667-5072

DOI: https://doi.org/10.52976/vansaglik.933072

Issues

Authors:

İsmail GÜLAÇAR | Zehra KAYA | Necat ALMALI | Can ATEŞ | Gözde YEŞİL SAYIN | Gökhan GÖRGİŞEN

Publisher:

Van Yuzuncu Yıl University

Main Topics:

Diseases

Journal:

Van Health Sciences Journal 2021 Vol.14 Issue 3, pp.298-303

Document Type:

Article

Publication Date:

12/2021

Document Language:

English

Document ID (Org No.):

2000679809

Frequency:

Tri-annual

eISSN:

2667-5072

pISSN:

2667-5072

DOI:

https://doi.org/10.52976/vansaglik.933072