A retrospective observational study of autologous peripheral blood stem-cell transplantation and long-term survival outcomes - An institutional experience

Mukesh Kumar; Sandeep Jasuja; Aditi Mittal; Krutika Goel; Ramkrishan Ramkrishan; Lalchand Mittal1; Suman Kapuria; Jaiprakash Yadav

Article Details

A retrospective observational study of autologous peripheral blood stem-cell transplantation and long-term survival outcomes - An institutional experience

Authors:

Mukesh Kumar | Sandeep Jasuja | Aditi Mittal | Krutika Goel | Ramkrishan Ramkrishan | Lalchand Mittal1 | Suman Kapuria | Jaiprakash Yadav

Publisher:

Ondokuz Mayıs University

Main Topics:

Health Care Administration

Journal:

Deneysel ve Klinik Tıp Dergisi Vol.40 Issue 3, pp.437-442

Document Type:

Article

Publication Date:

9/2023

Document Language:

English

Document ID (Org No.):

2001300585

pISSN:

1309-4483

Keywords:

Abstract:

 Autologous peripheral blood stem cell transplantation PBSCT has been employed in patients with various haematological and non-haematological malignancies. The present retrospective study aimed to examine the clinical efficacy and overall long-term survival outcomes of the patients who underwent autologous PBSCT. The clinical data of 49 patients with various haematological and non-haematological malignancies from the Department of Haematology of SMS Hospital from April 2015 to March 2021 were retrospectively analysed. The median age of our patients was 41.5 years. Among all indications, relapsed hodgkins lymphoma 10, 20.4 and multiple myeloma 27, 55.1 were reported to be high. The average engraftment was observed to be 11 days with no post-operative complications. The average follow-up period was 2.5 years with a mortality rate of 8.16 4. Overall, a total of 43 87.75 patients showed a complete response with a relapse rate of 12.24 6. In conclusion, autologous PBSCT can be an effective treatment option with good clinical efficacy, and long term survival outcomes. Our results are comparable to those of many national and international published reports. Overall, the results suggest that with improved management of conditioning-related toxicities and infections, it is possible to develop PBSCT programs in third-world countries and achieve outcomes comparable to those in the international data.

 Autologous peripheral blood stem cell transplantation PBSCT has been employed in patients with various haematological and non-haematological malignancies. The present retrospective study aimed to examine the clinical efficacy and overall long-term survival outcomes of the patients who underwent autologous PBSCT. The clinical data of 49 patients with various haematological and non-haematological malignancies from the Department of Haematology of SMS Hospital from April 2015 to March 2021 were retrospectively analysed. The median age of our patients was 41.5 years. Among all indications, relapsed hodgkins lymphoma 10, 20.4 and multiple myeloma 27, 55.1 were reported to be high. The average engraftment was observed to be 11 days with no post-operative complications. The average follow-up period was 2.5 years with a mortality rate of 8.16 4. Overall, a total of 43 87.75 patients showed a complete response with a relapse rate of 12.24 6. In conclusion, autologous PBSCT can be an effective treatment option with good clinical efficacy, and long term survival outcomes. Our results are comparable to those of many national and international published reports. Overall, the results suggest that with improved management of conditioning-related toxicities and infections, it is possible to develop PBSCT programs in third-world countries and achieve outcomes comparable to those in the international data.

 Autologous peripheral blood stem cell transplantation PBSCT has been employed in patients with various haematological and non-haematological malignancies. The present retrospective study aimed to examine the clinical efficacy and overall long-term survival outcomes of the patients who underwent autologous PBSCT. The clinical data of 49 patients with various haematological and non-haematological malignancies from the Department of Haematology of SMS Hospital from April 2015 to March 2021 were retrospectively analysed. The median age of our patients was 41.5 years. Among all indications, relapsed hodgkins lymphoma 10, 20.4 and multiple myeloma 27, 55.1 were reported to be high. The average engraftment was observed to be 11 days with no post-operative complications. The average follow-up period was 2.5 years with a mortality rate of 8.16 4. Overall, a total of 43 87.75 patients showed a complete response with a relapse rate of 12.24 6. In conclusion, autologous PBSCT can be an effective treatment option with good clinical efficacy, and long term survival outcomes. Our results are comparable to those of many national and international published reports. Overall, the results suggest that with improved management of conditioning-related toxicities and infections, it is possible to develop PBSCT programs in third-world countries and achieve outcomes comparable to those in the international data.

 Autologous peripheral blood stem cell transplantation PBSCT has been employed in patients with various haematological and non-haematological malignancies. The present retrospective study aimed to examine the clinical efficacy and overall long-term survival outcomes of the patients who underwent autologous PBSCT. The clinical data of 49 patients with various haematological and non-haematological malignancies from the Department of Haematology of SMS Hospital from April 2015 to March 2021 were retrospectively analysed. The median age of our patients was 41.5 years. Among all indications, relapsed hodgkins lymphoma 10, 20.4 and multiple myeloma 27, 55.1 were reported to be high. The average engraftment was observed to be 11 days with no post-operative complications. The average follow-up period was 2.5 years with a mortality rate of 8.16 4. Overall, a total of 43 87.75 patients showed a complete response with a relapse rate of 12.24 6. In conclusion, autologous PBSCT can be an effective treatment option with good clinical efficacy, and long term survival outcomes. Our results are comparable to those of many national and international published reports. Overall, the results suggest that with improved management of conditioning-related toxicities and infections, it is possible to develop PBSCT programs in third-world countries and achieve outcomes comparable to those in the international data.

Article Details

A retrospective observational study of autologous peripheral blood stem-cell transplantation and long-term survival outcomes - An institutional experience

Authors:

Mukesh Kumar | Sandeep Jasuja | Aditi Mittal | Krutika Goel | Ramkrishan Ramkrishan | Lalchand Mittal1 | Suman Kapuria | Jaiprakash Yadav

Publisher:

Ondokuz Mayıs University

Main Topics:

Health Care Administration

Journal:

Deneysel ve Klinik Tıp Dergisi Vol.40 Issue 3, pp.437-442

Document Type:

Article

Publication Date:

9/2023

Document Language:

English

Document ID (Org No.):

2001300585

pISSN:

1309-4483

Autologous transplantation

peripheral blood stem-cell transplantation

conditioning regimen

retrospective observational study

survival outcomes.Autologous transplantation

peripheral blood stem-cell transplantation

conditioning regimen

retrospective observational study

survival outcomes.

Issues

Article Details

Authors: Mukesh Kumar | Sandeep Jasuja | Aditi Mittal | Krutika Goel | Ramkrishan Ramkrishan | Lalchand Mittal1 | Suman Kapuria | Jaiprakash Yadav

Publisher: Ondokuz Mayıs University

Main Topics: Health Care Administration

Journal: Deneysel ve Klinik Tıp Dergisi Vol.40 Issue 3, pp.437-442

Document Type: Article

Publication Date: 9/2023

Document Language: English

Document ID (Org No.): 2001300585

pISSN: 1309-4483

Issues

Authors:

Mukesh Kumar | Sandeep Jasuja | Aditi Mittal | Krutika Goel | Ramkrishan Ramkrishan | Lalchand Mittal1 | Suman Kapuria | Jaiprakash Yadav

Publisher:

Ondokuz Mayıs University

Main Topics:

Health Care Administration

Journal:

Deneysel ve Klinik Tıp Dergisi Vol.40 Issue 3, pp.437-442

Document Type:

Article

Publication Date:

9/2023

Document Language:

English

Document ID (Org No.):

2001300585

pISSN:

1309-4483