Formulation and Evaluation of Immediate-Release Tablet Containing Atorvastatin Phospholipid Solid Dispersion

N.A.

Article Details

Formulation and Evaluation of Immediate-Release Tablet Containing Atorvastatin Phospholipid Solid Dispersion

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmaceutical Delivery Technologies | Clinical Pharmacology and Therapeutics

Journal:

Journal of Research in Pharmacy Vol.28 Issue 3, pp.641-650

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001346633

pISSN:

2630-6344

Keywords:

Abstract:

 Oral tablets containing solubilized drug in the presence of appropriate excipients may give us an immediate release of the drug. Phospholipid solid dispersion PSD is a branch of solid dispersion in which phospholipid acts as a hydrophilic polymer in the presence of a suitable adsorbent to enhance the solubility of poorly soluble drugs. The anti-hyperlipidemic drug Atorvastatin ATR is an example of such drug, as it belongs to the class II group according to the biopharmaceutical classification system BCS with low bioavailability due to its low solubility. Phosphatidylcholine in combination with magnesium aluminum silicate as an adsorbent in a ratio of ATR: PC: MAS 1:3:4 was used to prepare ATR PSD by the solvent evaporation method, the product showed acceptable physical properties and utilized for the preparation of immediate-release tablets IRTs of ATR. Ten formulas of ATR- IRTs were prepared by direct compression method using different types and concentrations of diluents AvicelPH102, AvicelPH101, and starch and superdisintegrants crospovidone, croscarmellose sodium, and sodium starch glycolate and evaluated for their drug content, weight variation, hardness, friability, in vitro disintegration time and dissolution profile. The tablets formula T10 that were prepared with ATR-PSD and AvicelPH102 as a diluent and Croscarmellose Sodium CCS 5 ww as super disintegrant show the shortest disintegration time DT 38 1 sec. and best drug release 91 within 15 min in 0.05M phosphate buffer pH 6.8.

 Oral tablets containing solubilized drug in the presence of appropriate excipients may give us an immediate release of the drug. Phospholipid solid dispersion PSD is a branch of solid dispersion in which phospholipid acts as a hydrophilic polymer in the presence of a suitable adsorbent to enhance the solubility of poorly soluble drugs. The anti-hyperlipidemic drug Atorvastatin ATR is an example of such drug, as it belongs to the class II group according to the biopharmaceutical classification system BCS with low bioavailability due to its low solubility. Phosphatidylcholine in combination with magnesium aluminum silicate as an adsorbent in a ratio of ATR: PC: MAS 1:3:4 was used to prepare ATR PSD by the solvent evaporation method, the product showed acceptable physical properties and utilized for the preparation of immediate-release tablets IRTs of ATR. Ten formulas of ATR- IRTs were prepared by direct compression method using different types and concentrations of diluents AvicelPH102, AvicelPH101, and starch and superdisintegrants crospovidone, croscarmellose sodium, and sodium starch glycolate and evaluated for their drug content, weight variation, hardness, friability, in vitro disintegration time and dissolution profile. The tablets formula T10 that were prepared with ATR-PSD and AvicelPH102 as a diluent and Croscarmellose Sodium CCS 5 ww as super disintegrant show the shortest disintegration time DT 38 1 sec. and best drug release 91 within 15 min in 0.05M phosphate buffer pH 6.8.

 Oral tablets containing solubilized drug in the presence of appropriate excipients may give us an immediate release of the drug. Phospholipid solid dispersion PSD is a branch of solid dispersion in which phospholipid acts as a hydrophilic polymer in the presence of a suitable adsorbent to enhance the solubility of poorly soluble drugs. The anti-hyperlipidemic drug Atorvastatin ATR is an example of such drug, as it belongs to the class II group according to the biopharmaceutical classification system BCS with low bioavailability due to its low solubility. Phosphatidylcholine in combination with magnesium aluminum silicate as an adsorbent in a ratio of ATR: PC: MAS 1:3:4 was used to prepare ATR PSD by the solvent evaporation method, the product showed acceptable physical properties and utilized for the preparation of immediate-release tablets IRTs of ATR. Ten formulas of ATR- IRTs were prepared by direct compression method using different types and concentrations of diluents AvicelPH102, AvicelPH101, and starch and superdisintegrants crospovidone, croscarmellose sodium, and sodium starch glycolate and evaluated for their drug content, weight variation, hardness, friability, in vitro disintegration time and dissolution profile. The tablets formula T10 that were prepared with ATR-PSD and AvicelPH102 as a diluent and Croscarmellose Sodium CCS 5 ww as super disintegrant show the shortest disintegration time DT 38 1 sec. and best drug release 91 within 15 min in 0.05M phosphate buffer pH 6.8.

 Oral tablets containing solubilized drug in the presence of appropriate excipients may give us an immediate release of the drug. Phospholipid solid dispersion PSD is a branch of solid dispersion in which phospholipid acts as a hydrophilic polymer in the presence of a suitable adsorbent to enhance the solubility of poorly soluble drugs. The anti-hyperlipidemic drug Atorvastatin ATR is an example of such drug, as it belongs to the class II group according to the biopharmaceutical classification system BCS with low bioavailability due to its low solubility. Phosphatidylcholine in combination with magnesium aluminum silicate as an adsorbent in a ratio of ATR: PC: MAS 1:3:4 was used to prepare ATR PSD by the solvent evaporation method, the product showed acceptable physical properties and utilized for the preparation of immediate-release tablets IRTs of ATR. Ten formulas of ATR- IRTs were prepared by direct compression method using different types and concentrations of diluents AvicelPH102, AvicelPH101, and starch and superdisintegrants crospovidone, croscarmellose sodium, and sodium starch glycolate and evaluated for their drug content, weight variation, hardness, friability, in vitro disintegration time and dissolution profile. The tablets formula T10 that were prepared with ATR-PSD and AvicelPH102 as a diluent and Croscarmellose Sodium CCS 5 ww as super disintegrant show the shortest disintegration time DT 38 1 sec. and best drug release 91 within 15 min in 0.05M phosphate buffer pH 6.8.

Article Details

Formulation and Evaluation of Immediate-Release Tablet Containing Atorvastatin Phospholipid Solid Dispersion

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmaceutical Delivery Technologies | Clinical Pharmacology and Therapeutics

Journal:

Journal of Research in Pharmacy Vol.28 Issue 3, pp.641-650

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001346633

pISSN:

2630-6344

Atorvastatin

Avicel® PH102

immediate-release tablets

Phospholipid solid dispersion

Issues

Article Details

Formulation and Evaluation of Immediate-Release Tablet Containing Atorvastatin Phospholipid Solid Dispersion

Authors: N.A.

Publisher: Marmara University

Main Topics: Pharmaceutical Delivery Technologies | Clinical Pharmacology and Therapeutics

Journal: Journal of Research in Pharmacy Vol.28 Issue 3, pp.641-650

Document Type: Article

Publication Date: 6/2025

Document Language: English

Document ID (Org No.): 2001346633

pISSN: 2630-6344

Atorvastatin

Avicel® PH102

immediate-release tablets

Phospholipid solid dispersion

Issues

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmaceutical Delivery Technologies | Clinical Pharmacology and Therapeutics

Journal:

Journal of Research in Pharmacy Vol.28 Issue 3, pp.641-650

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001346633

pISSN:

2630-6344