Circulating Micrornas : Potential Biomarkers in Cancer Detection , Diagnosis and Prognosis

Nader Makarem; Ahmad Mourad; Farah J. Nassar; Rihab Nasr

doi:10.12816/0027471

Article Details

Circulating Micrornas : Potential Biomarkers in Cancer Detection , Diagnosis and Prognosis

Authors:

Nader Makarem | Ahmad Mourad | Farah J. Nassar | Rihab Nasr

Publisher:

Lebanese Order of Physicians : Scientific Committee

Main Topics:

Medicine

Journal:

Lebanese Medical Journal 2016 Vol.64 Issue 2, pp.116-122

Document Type:

Article

Publication Date:

6/2016

Document Language:

English

Document ID (Org No.):

88361

Frequency:

Quarterly

pISSN:

00239852

DOI:

10.12816/0027471

Descriptors:

Keywords:

Abstract:

 A large family of small 18-25 nucleotide long non coding RNA molecules now known as microRNA (miRNA) was described two decades ago, and has been recently established as post-transcriptional gene regulators. miRNAs were shown to be involved in the regulation of diverse physiological and developmental processes. Moreover, dysregulation of specific miRNAs has been implicated later in several pathologies including cancer. Owing to their presence and stability in body fluids, miRNAs have been investigated as novel circulating non-invasive biomarkers. Accordingly, their role as potential diagnostic, prognostic or predictive biomarkers for many cancer types has recently emerged. This review tackles the use of circulating miRNAs in cancer detection, diagnosis and prognosis, giving examples using common solid tumors and discussing the advantages of their use, the challenges facing this novel circulating biomarker and recommendations to overcome them.

 Les microARN (miARNs), decouverts il y a deux decennies, forment une grande famille de petites molecules d’ARNs non codants de 18 a 25 nucleotides de longueur. Recemment, plusieurs recherches ont prouve que les miARNs sont des regulateurs post-transcriptionnels de genes impliques dans la regulation du developpement et de divers processus physiologiques. De plus, la deregulation de certains miARNs semble etre a l’origine de plusieurs pathologies, dont le cancer. En raison de leur presence et de leur stabilite dans des fluides corporels, les miARNs ont ete etudies en tant que biomarqueurs diagnostiques, pronostiques ou predictifs non invasifs pour de nombreux types de cancer. Cet article aborde l’utilisation des miARNs circulants dans la detection, le diagnostic et le pronostic de certaines tumeurs solides et examine les avantages de leur utilisation, les defis auxquels ces nouveaux biomarqueurs circulants feront face et certaines recommandations pour les surmonter.

Article Details

Circulating Micrornas : Potential Biomarkers in Cancer Detection , Diagnosis and Prognosis

Authors:

Nader Makarem | Ahmad Mourad | Farah J. Nassar | Rihab Nasr

Publisher:

Lebanese Order of Physicians : Scientific Committee

Main Topics:

Medicine

Journal:

Lebanese Medical Journal 2016 Vol.64 Issue 2, pp.116-122

Document Type:

Article

Publication Date:

6/2016

Document Language:

English

Document ID (Org No.):

88361

Frequency:

Quarterly

pISSN:

00239852

DOI:

10.12816/0027471

Descriptors:

CANCER

DIAGNOSIS

BIOLOGICAL INDICATORS

HEREDITY

Microrna

Cancer

Biomarker

Prognosis

Diagnosis

Issues

Article Details

Authors: Nader Makarem | Ahmad Mourad | Farah J. Nassar | Rihab Nasr

Publisher: Lebanese Order of Physicians : Scientific Committee

Main Topics: Medicine

Journal: Lebanese Medical Journal 2016 Vol.64 Issue 2, pp.116-122

Document Type: Article

Publication Date: 6/2016

Document Language: English

Document ID (Org No.): 88361

Frequency: Quarterly

pISSN: 00239852

DOI: 10.12816/0027471

Descriptors:

Issues

Authors:

Nader Makarem | Ahmad Mourad | Farah J. Nassar | Rihab Nasr

Publisher:

Lebanese Order of Physicians : Scientific Committee

Main Topics:

Medicine

Journal:

Lebanese Medical Journal 2016 Vol.64 Issue 2, pp.116-122

Document Type:

Article

Publication Date:

6/2016

Document Language:

English

Document ID (Org No.):

88361

Frequency:

Quarterly

pISSN:

00239852

DOI:

10.12816/0027471