Increased Concentrations of Interleukin-33 in the Serum and Cerebrospinal Fluid of Patients with Multiple Sclerosis

Abdollah Jafarzadeh; Roya Mahdavi; Mitra Jamali; Hossain Hajghani; Maryam Nemati; Hossain Ali Ebrahimi

doi:10.5001/omj.2016.08

Article Details

Increased Concentrations of Interleukin-33 in the Serum and Cerebrospinal Fluid of Patients with Multiple Sclerosis

Authors:

Abdollah Jafarzadeh | Roya Mahdavi | Mitra Jamali | Hossain Hajghani | Maryam Nemati | Hossain Ali Ebrahimi

Publisher:

Oman Medical Specialty Board

Main Topics:

Medicine

Journal:

Oman Medical Journal 2016 Vol.31 Issue 1, pp.40-45

Document Type:

Article

Publication Date:

1/2016

Document Language:

English

Document ID (Org No.):

84498

Frequency:

Bi-Monthly

eISSN:

20705204

pISSN:

1999768X

DOI:

10.5001/omj.2016.08

Descriptors:

Keywords:

Abstract:

 Objectives: Interleukin (IL)-33 is a cytokine with both pro- and anti-inflammatoryeffects involved in the pathogenesis of some inflammatory diseases. The purpose of thisinvestigation was to evaluate the serum and cerebrospinal fluid (CSF) IL-33 concentrationsin patients with multiple sclerosis (MS). Methods: Blood specimens were obtainedfrom 140 patients with MS (46 males and 94 females) with various disease patternsand treatment plans and 140 healthy subjects (47 males and 93 females), who acted asa control group. CSF samples were collected from 20 MS group and 20 sex- and agematchedpatients with other neurological diseases of nonautoimmune etiology. The serumand CSF concentrations of IL-33 were measured by the enzyme-linked immunosorbentassay. Results: The serum and CSF IL-33 levels were significantly higher in the MS groupcompared to the control group (p<0.001 and p<0.050, respectively). The serum IL-33concentrations were also significantly higher in newly diagnosed (untreated) patients andpatients treated with methylprednisolone or with interferon-β and methylprednisolonecompared to the healthy patient group (p<0.007, p<0.002, and p<0.010, respectively).Moreover, the serum IL-33 concentrations in patients with relapsing-remitting (RRMS),primary progressive (PPMS), and secondary progressive (SPMS) forms of the disease weresignificantly higher than in the healthy control group (p<0.006, p<0.001, and p<0.020,respectively). Conclusions: Our results showed increased concentrations of IL-33 inpatients with MS including both untreated and treated MS patients and patients withthe RRMS, SPMS, and PPMS forms. This suggests that IL-33 may be involved in thepathogenesis of all MS forms and treatment with methylprednisolone or both interferon-βplus methylprednisolone has no influence on IL-33 concentrations.

Article Details

Increased Concentrations of Interleukin-33 in the Serum and Cerebrospinal Fluid of Patients with Multiple Sclerosis

Authors:

Abdollah Jafarzadeh | Roya Mahdavi | Mitra Jamali | Hossain Hajghani | Maryam Nemati | Hossain Ali Ebrahimi

Publisher:

Oman Medical Specialty Board

Main Topics:

Medicine

Journal:

Oman Medical Journal 2016 Vol.31 Issue 1, pp.40-45

Document Type:

Article

Publication Date:

1/2016

Document Language:

English

Document ID (Org No.):

84498

Frequency:

Bi-Monthly

eISSN:

20705204

pISSN:

1999768X

DOI:

10.5001/omj.2016.08

Descriptors:

MEDICAL SCIENCES

MULTIPLE SCLEROSIS

INTERLEUKINS

BLOOD SERUM

CEREBROSPINAL FLUID

PATIENTS

THERAPY

Multiple Sclerosis

IL33 Protein

Human

Treatment

Issues

Article Details

Authors: Abdollah Jafarzadeh | Roya Mahdavi | Mitra Jamali | Hossain Hajghani | Maryam Nemati | Hossain Ali Ebrahimi

Publisher: Oman Medical Specialty Board

Main Topics: Medicine

Journal: Oman Medical Journal 2016 Vol.31 Issue 1, pp.40-45

Document Type: Article

Publication Date: 1/2016

Document Language: English

Document ID (Org No.): 84498

Frequency: Bi-Monthly

eISSN: 20705204

pISSN: 1999768X

DOI: 10.5001/omj.2016.08

Descriptors:

Issues

Authors:

Abdollah Jafarzadeh | Roya Mahdavi | Mitra Jamali | Hossain Hajghani | Maryam Nemati | Hossain Ali Ebrahimi

Publisher:

Oman Medical Specialty Board

Main Topics:

Medicine

Journal:

Oman Medical Journal 2016 Vol.31 Issue 1, pp.40-45

Document Type:

Article

Publication Date:

1/2016

Document Language:

English

Document ID (Org No.):

84498

Frequency:

Bi-Monthly

eISSN:

20705204

pISSN:

1999768X

DOI:

10.5001/omj.2016.08