Novel biologically active glycosides from the aerial parts of Cephalaria gazipashensis

Nazlı Böke Sarikahya And Süheyla KIRMIZIGÜL

Article Details

Novel biologically active glycosides from the aerial parts of Cephalaria gazipashensis

Authors:

Nazlı Böke Sarikahya And Süheyla KIRMIZIGÜL

Publisher:

TUBITAK

Journal:

Turkish Journal of Chemistry 2012 Vol.36 Issue 2, pp.323-334

Document Type:

Article

Publication Date:

1/2012

Document Language:

Turkish

Document ID (Org No.):

2000727668

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527

Abstract:

 

Two new triterpene glycosides, 3-O-b-D-glucopyranosyl-  (1\to 4)-b-D-xylopyranosyl-(1\to 3)-a-L-rhamnopyranosyl-  (1\to 3)-a-L-arabinopyranosyl olean-12-ene 28-O-b -D-  glucopyranosyl-(1\to 6)-b-D-glucopyranosyl ester (gazipashoside   A, 1) and 3-O-b-D-glucopyranosyl-(1\to 4)-b-D-xylopyranosyl-  (1\to 3)-a-L-rhamnopyranosyl-(1\to 2)-a-L-arabinopyranosyl  hederagenin 28-O-b -D-glucopyranosyl-(1\to 6)-b-D-glucopyranosyl  ester (gazipashoside B, 2), were isolated together with 11 known  compounds including 7 triterpene, 1 flavonoid, and 3 iridoidal  metabolites from the aerial parts of Cephalaria gazipashensis  (Dipsacaceae).  The structures of all compounds were elucidated by  extensive evaluation of the spectroscopic data (1D- and 2D- NMR,  HRESI-MS), as well as chemical examinations.  The antimicrobial  effects of all pure compounds were tested against gram-positive and  gram-negative bacteria.  The results indicated that the 2 new  triterpene glycosides might be acceptable as antimicrobial active  agents.

 

Two new triterpene glycosides, 3-O-b-D-glucopyranosyl-  (1\to 4)-b-D-xylopyranosyl-(1\to 3)-a-L-rhamnopyranosyl-  (1\to 3)-a-L-arabinopyranosyl olean-12-ene 28-O-b -D-  glucopyranosyl-(1\to 6)-b-D-glucopyranosyl ester (gazipashoside   A, 1) and 3-O-b-D-glucopyranosyl-(1\to 4)-b-D-xylopyranosyl-  (1\to 3)-a-L-rhamnopyranosyl-(1\to 2)-a-L-arabinopyranosyl  hederagenin 28-O-b -D-glucopyranosyl-(1\to 6)-b-D-glucopyranosyl  ester (gazipashoside B, 2), were isolated together with 11 known  compounds including 7 triterpene, 1 flavonoid, and 3 iridoidal  metabolites from the aerial parts of Cephalaria gazipashensis  (Dipsacaceae).  The structures of all compounds were elucidated by  extensive evaluation of the spectroscopic data (1D- and 2D- NMR,  HRESI-MS), as well as chemical examinations.  The antimicrobial  effects of all pure compounds were tested against gram-positive and  gram-negative bacteria.  The results indicated that the 2 new  triterpene glycosides might be acceptable as antimicrobial active  agents.

Article Details

Novel biologically active glycosides from the aerial parts of Cephalaria gazipashensis

Authors: Nazlı Böke Sarikahya And Süheyla KIRMIZIGÜL

Publisher: TUBITAK

Journal: Turkish Journal of Chemistry 2012 Vol.36 Issue 2, pp.323-334

Document Type: Article

Publication Date: 1/2012

Document Language: Turkish

Document ID (Org No.): 2000727668

Frequency: Bimonthly

eISSN: 1303-6130

pISSN: 1300-0527

Issues

Authors:

Nazlı Böke Sarikahya And Süheyla KIRMIZIGÜL

Publisher:

TUBITAK

Journal:

Turkish Journal of Chemistry 2012 Vol.36 Issue 2, pp.323-334

Document Type:

Article

Publication Date:

1/2012

Document Language:

Turkish

Document ID (Org No.):

2000727668

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527