Evaluation of protective effects of mirtazapine and mesna on cisplatin-induced ovarian damage in rats

Ali Doğukan ANĞIN; Muhammet Ali ORUÇ; Önder SAKİN; Emine Eda AKALIN; Muzaffer ÇIKMAN; Kayhan BAŞAK; Yasemin ALAN; Asuman ORÇUN; Murat ALAN

Article Details

Evaluation of protective effects of mirtazapine and mesna on cisplatin-induced ovarian damage in rats

Authors:

Ali Doğukan ANĞIN | Muhammet Ali ORUÇ | Önder SAKİN | Emine Eda AKALIN | Muzaffer ÇIKMAN | Kayhan BAŞAK | Yasemin ALAN | Asuman ORÇUN | Murat ALAN

Publisher:

Ondokuz Mayıs University

Main Topics:

Promotion of health

Journal:

Journal of Experimental and Clinical Medicine 2021 Vol.38 Issue 2, pp.72-81

Document Type:

Article

Publication Date:

4/2021

Document Language:

English

Document ID (Org No.):

2000507649

Frequency:

Quarterly

eISSN:

1309-5129

pISSN:

1309-4483

Abstract:

 

Evaluation of protective effects of mirtazapine and mesna on cisplatin-induced ovarian damage in rats
Objective:
To evaluate whether mirtazapine and mesna have protective effects on cisplatin-induced ovarian injury.
Methods:
A total of 32 female Wistar Albino rats were divided into 4 groups (8 rats per group) and included in the study. No medication was administered to the first group; only intervention was that their ovaries were removed and anti-mullerian hormone (AMH) values were measured. The second group received intramuscular cisplatin at a single dose of 7.5 mg/kg. The third group received a single dose of 200 mg/kg mesna intraperitoneally, and 30 minutes later, a single dose of 7.5 mg/kg intramuscular cisplatin was administered. The fourth group received oral 30 mg/kg mirtazapine, and 60 minutes later, a single dose of 7.5 mg/kg intramuscular cisplatin was administered. Oral 30 mg/kg mirtazapine was continued for ten days. Ovaries and AMH values of all groups were evaluated at the end of tenth day.
Results:
In the cisplatin group when compared to normal ovarian tissue total histopathological damage score increased (p=0.037), preantral follicle count decreased (p=0.003) and AMH levels decreased (p<0.001). In the cisplatin+mesna group total ovarian damage score was also increased (p=0.005), preantral and antral follicles decreased (p<0.001 and p=0.001, respectively), and AMH levels decreased (p<0.001). In the cisplatin+mirtazapine group, total ovarian damage score (p <0.001), preantral follicle count (p = 0.002) and AMH values were decreased (p <0.001).
Conclusion:
It was concluded that mesna and mirtazapine were not effective in preventing ovarian damage due to cisplatin.

Article Details

Evaluation of protective effects of mirtazapine and mesna on cisplatin-induced ovarian damage in rats

Authors: Ali Doğukan ANĞIN | Muhammet Ali ORUÇ | Önder SAKİN | Emine Eda AKALIN | Muzaffer ÇIKMAN | Kayhan BAŞAK | Yasemin ALAN | Asuman ORÇUN | Murat ALAN

Publisher: Ondokuz Mayıs University

Main Topics: Promotion of health

Journal: Journal of Experimental and Clinical Medicine 2021 Vol.38 Issue 2, pp.72-81

Document Type: Article

Publication Date: 4/2021

Document Language: English

Document ID (Org No.): 2000507649

Frequency: Quarterly

eISSN: 1309-5129

pISSN: 1309-4483

Issues

Authors:

Ali Doğukan ANĞIN | Muhammet Ali ORUÇ | Önder SAKİN | Emine Eda AKALIN | Muzaffer ÇIKMAN | Kayhan BAŞAK | Yasemin ALAN | Asuman ORÇUN | Murat ALAN

Publisher:

Ondokuz Mayıs University

Main Topics:

Promotion of health

Journal:

Journal of Experimental and Clinical Medicine 2021 Vol.38 Issue 2, pp.72-81

Document Type:

Article

Publication Date:

4/2021

Document Language:

English

Document ID (Org No.):

2000507649

Frequency:

Quarterly

eISSN:

1309-5129

pISSN:

1309-4483