Visual qualitative evaluation of diffusion-weighted imaging, apparent diffusion coefficient quantification and Ki-67 proliferation index for predicting atypia in surgical meningiomas

Baran YİLMAZ; Süleyman SENER; Hasanaov TEYYUB; Akın AKAKIN; Özlem YAPICIER; Mustafa Kemal DEMİR

doi:https://doi.org/10.5472/marumj.413158

Article Details

Visual qualitative evaluation of diffusion-weighted imaging, apparent diffusion coefficient quantification and Ki-67 proliferation index for predicting atypia in surgical meningiomas

Authors:

Baran YİLMAZ | Süleyman SENER | Hasanaov TEYYUB | Akın AKAKIN | Özlem YAPICIER | Mustafa Kemal DEMİR

Publisher:

Marmara University

Main Topics:

Diseases

Journal:

Marmara Medical Journal 2018 Vol.31 Issue 2, pp.68-75

Document Type:

Article

Publication Date:

4/2018

Document Language:

English

Document ID (Org No.):

2000544432

Frequency:

Monthly

eISSN:

1309-9469

pISSN:

1019-1941

DOI:

https://doi.org/10.5472/marumj.413158

Abstract:

 


Object. The goal in this study was to investigate the
efficiency of qualitative evaluation using DW imaging, ADC quantification, and Ki-67 proliferation labeling index in grading
intracranial meningiomas compared to our reference standard histopathology.


Methods.
From our database, we enrolled 35 consecutive patients
with pathologic report of a meningioma, conventional
MR imaging, contrast-enhanced MR imaging, DW imaging and ADC maps.


Results.
Eight patients (23%) had atypical
meningioma (5 women and 3 men; mean age: 57.1±15.8
years); 27 (77%) had low-grade-typical (19 women, 8 men; mean age: 54.3±14.0 years). The most frequent histological subtype
was the meningothelial type in both low-grade (37%) and atypical meningiomas
(59%). The mean Ki-67 proliferation index for low-grade and atypical
meningiomas were 2.31±1.44% (range: 1-5) and 7.37 ±
2.72% (range: 3-10), respectively. Meningiomas
with Ki-67 proliferation index higher than 4% (except one) were atypical
(p<0.001). In visual qualitative evaluation;
diffusion restriction was significantly
more common in atypical meningiomas (p<0.05). In
quantitative evaluation, benign and atypical tumor
groups had no significant difference in mean ADC values (p=0.471).









Conclusion.
We suggest that visual qualitative
evaluation of DW imaging may be helpful to predict atypia and the risk of
recurrence in patients with surgically treated meningiomas.


.

 


Amaç:  Bu çalışmada amacımız, intrakranyal
meningiomların derecelendirmesinde görsel kalitatif DW görüntüleme, ADC
kantifikasyonu ve Ki-67 proliferasyon indeksinin referans standart
histopatoloji ile karşılaştırıldığında etkinliğini araştırmaktır. 


Gereç ve
Yöntem:  Patolojisi meningiom olarak
rapor edilmiş toplam 35 hastamızın, konvansiyonel MR görüntülemeleri,
kontrastlı MR görüntülemeleri, DW görüntülemeleri ve ADC haritaları
arşivimizden elde edilmiştir. 


Bulgular:
Sekiz hastada (23%) atipik (5 kadın ve 3 erkek; ortalama yaş: 57.1±15.8 yıl);
27 hastada ise (77%) düşük dereceli tipik meningiom (19 kadın, 8 erkek;
ortalama yaş: 54.3±14.0 yıl) vardı. Hem (59%) en sık histolojik alttip
meningotelyal tip idi. Ki-67 proliferasyon indeksi, düşük dereceli ve atipik
meningiomlarda sırasıyla 2.31±1.44% (aralık: 1-5) and 7.37 ± 2.72% (aralık:
3-10) olarak saptandı. Görsel kalitatif değerlendirmede, difüzyon kısıtlanması
atipi meningiomlarda daha belirgindi (p<0.05). Kantitatif değerlendirmede,
ADC değerlerinde heriki grup arasında anlamlı fark saptanmadı (p=0.471). 









Sonuç :
Görsel kalitatif DW görüntüleme değerlendirmesinin, atipi ve cerrahi tedavi
uygulanmış meningiom hastalarında tekrarlama riskinin tahmininde yardımcı
olabileceğini önermekteyiz.


.

Article Details

Visual qualitative evaluation of diffusion-weighted imaging, apparent diffusion coefficient quantification and Ki-67 proliferation index for predicting atypia in surgical meningiomas

Authors: Baran YİLMAZ | Süleyman SENER | Hasanaov TEYYUB | Akın AKAKIN | Özlem YAPICIER | Mustafa Kemal DEMİR

Publisher: Marmara University

Main Topics: Diseases

Journal: Marmara Medical Journal 2018 Vol.31 Issue 2, pp.68-75

Document Type: Article

Publication Date: 4/2018

Document Language: English

Document ID (Org No.): 2000544432

Frequency: Monthly

eISSN: 1309-9469

pISSN: 1019-1941

DOI: https://doi.org/10.5472/marumj.413158

Issues

Authors:

Baran YİLMAZ | Süleyman SENER | Hasanaov TEYYUB | Akın AKAKIN | Özlem YAPICIER | Mustafa Kemal DEMİR

Publisher:

Marmara University

Main Topics:

Diseases

Journal:

Marmara Medical Journal 2018 Vol.31 Issue 2, pp.68-75

Document Type:

Article

Publication Date:

4/2018

Document Language:

English

Document ID (Org No.):

2000544432

Frequency:

Monthly

eISSN:

1309-9469

pISSN:

1019-1941

DOI:

https://doi.org/10.5472/marumj.413158