Cell Cycle Control Part I cdc related kinases

M. Akif Öztürk

Article Details

Cell Cycle Control Part I cdc related kinases

Authors:

M. Akif Öztürk

Publisher:

Islamic World Academy of Sciences (IAS)

Journal:

Medical Journal of Islamic World Academy of Sciences Vol.6 Issue 4, pp.311-318

Document Type:

Article

Publication Date:

1/1993

Document Language:

English

Document ID (Org No.):

2001937475

pISSN:

2415-1300

Keywords:

Abstract:

 The central and rate-limiting function in the cell cycle control is performed by p34cdc2 kinase in lower organisms, and by p33cdk2 and p34cdc2 in higher organisms. This control is highly conserved throughout evolution. The activities of these kinases are regulated by phosphorylation and dephosphorylation as well as interaction with the cyclins during different phases of the cell cycle. The product p34cdc2 regulates both G1/S and G2/M transitions in yeast. While it is generally accepted that cdk2 plays a critical direct role at G1/S transition in mammalian cells. However, the functions of human cdc2-related kinases, other than cdk2 and cdk3, remain obscure. Certainly the active kinase forms phosphorylate a large number of proteins and enzymes involved in nuclear and nucleolar structures, cellular cytoskeletal systems, and DNA spindle fiber associated relations during mitosis. All of these are logical targets for cell cycle control, or at least its last stage, mitosis.

Article Details

Cell Cycle Control Part I cdc related kinases

Authors:

M. Akif Öztürk

Publisher:

Islamic World Academy of Sciences (IAS)

Journal:

Medical Journal of Islamic World Academy of Sciences Vol.6 Issue 4, pp.311-318

Document Type:

Article

Publication Date:

1/1993

Document Language:

English

Document ID (Org No.):

2001937475

pISSN:

2415-1300

Cell cycle

p34cdc2

cdks

mitosis

protein kinases

Issues

Article Details

Cell Cycle Control Part I cdc related kinases

Authors: M. Akif Öztürk

Publisher: Islamic World Academy of Sciences (IAS)

Journal: Medical Journal of Islamic World Academy of Sciences Vol.6 Issue 4, pp.311-318

Document Type: Article

Publication Date: 1/1993

Document Language: English

Document ID (Org No.): 2001937475

pISSN: 2415-1300

Cell cycle

p34cdc2

cdks

mitosis

protein kinases

Issues

Authors:

M. Akif Öztürk

Publisher:

Islamic World Academy of Sciences (IAS)

Journal:

Medical Journal of Islamic World Academy of Sciences Vol.6 Issue 4, pp.311-318

Document Type:

Article

Publication Date:

1/1993

Document Language:

English

Document ID (Org No.):

2001937475

pISSN:

2415-1300