Can Inflammatory Indexes Predict the Severity of Mucosal Inflammation in Ulcerative Colitis?

İrfan Küçük; Ersin Tural

Article Details

Can Inflammatory Indexes Predict the Severity of Mucosal Inflammation in Ulcerative Colitis?

Authors:

İrfan Küçük | Ersin Tural

Publisher:

Duzce University

Main Topics:

Gastroenterology and Hepatology

Journal:

Duzce Medical Journal Vol.26 Issue 3, pp.191-197

Document Type:

Article

Publication Date:

12/2024

Document Language:

English

Document ID (Org No.):

2001329229

pISSN:

1307-671X

Keywords:

Abstract:

 Aim: Inflammatory indexes can relate to disease activity in ulcerative colitis UC. This study aimed to evaluate whether the inflammatory indexes of neutrophil-lymphocyte ratio NLR, C-reactive protein CRP-albumin ratio CAR, CRP-lymphocyte ratio CLR, and systemic immune-inflammation index SIII might predict the severity of mucosal inflammation in UC. Material and Methods: This retrospective case-control study included 184 UC patients and 101 healthy controls. The Mayo clinical score and Mayo endoscopic score were used for the clinical and endoscopic features of UC. Truelove and Richardss method for the severity of mucosal inflammation determined the histological activity index HAI. Results: The inflammatory index values, were higher in UC patients compared to the control group p0.007 for NLR, and p0.001 for the others. The patients having endoscopic, clinic, and histologically active disease had higher inflammatory index values than those in remission p0.001 for all. UC patients with extensive disease had higher inflammatory index values than the patients who had limited disease p0.001 for all. The HAI values were positively correlated to all inflammatory indexes, and the correlation was the strongest between the HAI and CLR rho0.737, p0.001. Regarding HAI, the diagnostic accuracy of all inflammatory indexes for detecting the clinically active disease was statistically significant, and there was no significant difference between them in terms of diagnostic accuracy. Conclusion: The inflammatory indexes of NLR, CAR, CLR, and SII might predict the severity of histological inflammation in UC.

 Aim: Inflammatory indexes can relate to disease activity in ulcerative colitis UC. This study aimed to evaluate whether the inflammatory indexes of neutrophil-lymphocyte ratio NLR, C-reactive protein CRP-albumin ratio CAR, CRP-lymphocyte ratio CLR, and systemic immune-inflammation index SIII might predict the severity of mucosal inflammation in UC. Material and Methods: This retrospective case-control study included 184 UC patients and 101 healthy controls. The Mayo clinical score and Mayo endoscopic score were used for the clinical and endoscopic features of UC. Truelove and Richardss method for the severity of mucosal inflammation determined the histological activity index HAI. Results: The inflammatory index values, were higher in UC patients compared to the control group p0.007 for NLR, and p0.001 for the others. The patients having endoscopic, clinic, and histologically active disease had higher inflammatory index values than those in remission p0.001 for all. UC patients with extensive disease had higher inflammatory index values than the patients who had limited disease p0.001 for all. The HAI values were positively correlated to all inflammatory indexes, and the correlation was the strongest between the HAI and CLR rho0.737, p0.001. Regarding HAI, the diagnostic accuracy of all inflammatory indexes for detecting the clinically active disease was statistically significant, and there was no significant difference between them in terms of diagnostic accuracy. Conclusion: The inflammatory indexes of NLR, CAR, CLR, and SII might predict the severity of histological inflammation in UC.

 Aim: Inflammatory indexes can relate to disease activity in ulcerative colitis UC. This study aimed to evaluate whether the inflammatory indexes of neutrophil-lymphocyte ratio NLR, C-reactive protein CRP-albumin ratio CAR, CRP-lymphocyte ratio CLR, and systemic immune-inflammation index SIII might predict the severity of mucosal inflammation in UC. Material and Methods: This retrospective case-control study included 184 UC patients and 101 healthy controls. The Mayo clinical score and Mayo endoscopic score were used for the clinical and endoscopic features of UC. Truelove and Richardss method for the severity of mucosal inflammation determined the histological activity index HAI. Results: The inflammatory index values, were higher in UC patients compared to the control group p0.007 for NLR, and p0.001 for the others. The patients having endoscopic, clinic, and histologically active disease had higher inflammatory index values than those in remission p0.001 for all. UC patients with extensive disease had higher inflammatory index values than the patients who had limited disease p0.001 for all. The HAI values were positively correlated to all inflammatory indexes, and the correlation was the strongest between the HAI and CLR rho0.737, p0.001. Regarding HAI, the diagnostic accuracy of all inflammatory indexes for detecting the clinically active disease was statistically significant, and there was no significant difference between them in terms of diagnostic accuracy. Conclusion: The inflammatory indexes of NLR, CAR, CLR, and SII might predict the severity of histological inflammation in UC.

 Amaç: İnflamatuar indekslerin ülseratif kolitte ÜK hastalık aktivitesi ile ilişkili oldukları bilinmektedir. Bu çalışma nötrofil-lenfosit oranı NLR, C-reaktif protein CRP-albümin oranı CAR, CRP-lenfosit oranı CLR ve sistemik immün-inflamasyon indeksini SIII içeren inflamatuar indekslerin ÜKde mukozal inflamasyonun şiddetini tahmin edip edemeyeceğinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: Bu retrospektif vaka kontrol çalışmasına 184 ÜK hastası ve 101 sağlıklı kontrol dahil edilmiştir. ÜKnin klinik ve endoskopik özellikleri için Mayo klinik skoru ve Mayo endoskopik skoru kullanılmıştır. Mukozal inflamasyon şiddeti, Truelove ve Richards yöntemine göre histolojik aktivite indeksi HAI ile belirlenmiştir. Bulgular: ÜK hastalarında, inflamatuar indeks değerleri kontrol grubuna göre daha yüksek bulunmuştur NLR için p0,007 ve diğerleri için p0,001. Endoskopik, klinik ve histolojik olarak aktif hastalığı olan vakaların inflamatuar indeks değerleri remisyonda olan vakalardan daha yüksek idi tümü için p0,001. Yaygın hastalığı olan ÜK hastalarının sınırlı hastalığı olan hastalardan daha yüksek inflamatuar indeks değerleri vardı tümü için p0,001. HAI değerleri tüm inflamatuar indekslerle pozitif korelasyon göstermekteydi ve en güçlü korelasyon HAI ile CLR arasında idi rho0,737; p0,001. HAI ile ilişkili olarak, klinik olarak aktif hastalığın tespiti için tüm inflamatuvar indekslerin tanısal doğruluğu istatistiksel olarak anlamlıydı ve tanısal doğruluk açısından aralarında anlamlı bir fark yoktu. Sonuç: NLR, CAR, CLR ve SIIIi içeren inflamatuar indeskler, ÜKde histolojik inflamasyonun şiddetini tahmin edebilir.

Article Details

Can Inflammatory Indexes Predict the Severity of Mucosal Inflammation in Ulcerative Colitis?

Authors:

İrfan Küçük | Ersin Tural

Publisher:

Duzce University

Main Topics:

Gastroenterology and Hepatology

Journal:

Duzce Medical Journal Vol.26 Issue 3, pp.191-197

Document Type:

Article

Publication Date:

12/2024

Document Language:

English

Document ID (Org No.):

2001329229

pISSN:

1307-671X

Ulcerative colitis

inflammatory indexes

mucosal inflammation.Ülseratif kolit

inflamatuar indeksler

mukozal inflamasyon

Issues

Article Details

Can Inflammatory Indexes Predict the Severity of Mucosal Inflammation in Ulcerative Colitis?

Authors: İrfan Küçük | Ersin Tural

Publisher: Duzce University

Main Topics: Gastroenterology and Hepatology

Journal: Duzce Medical Journal Vol.26 Issue 3, pp.191-197

Document Type: Article

Publication Date: 12/2024

Document Language: English

Document ID (Org No.): 2001329229

pISSN: 1307-671X

Ulcerative colitis

inflammatory indexes

mucosal inflammation.Ülseratif kolit

inflamatuar indeksler

mukozal inflamasyon

Issues

Authors:

İrfan Küçük | Ersin Tural

Publisher:

Duzce University

Main Topics:

Gastroenterology and Hepatology

Journal:

Duzce Medical Journal Vol.26 Issue 3, pp.191-197

Document Type:

Article

Publication Date:

12/2024

Document Language:

English

Document ID (Org No.):

2001329229

pISSN:

1307-671X