The effect of N-acetylcysteine on growth and biofilm formation in Staphylococcus epidermidis strains

Sahra KIRMUSAOĞLU; Seyhun YURDUGÜL; M. Esra KOÇOĞLU

Article Details

The effect of N-acetylcysteine on growth and biofilm formation in Staphylococcus epidermidis strains

Authors:

Sahra KIRMUSAOĞLU | Seyhun YURDUGÜL | M. Esra KOÇOĞLU

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2012 Vol.42 Issue 4, pp.689-694

Document Type:

Article

Publication Date:

3/2012

Document Language:

Turkish

Document ID (Org No.):

2000754116

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Keywords:

Abstract:

 

Aim: To examine the possible preventive effect of N-acetylcysteine (NAC) on biofilm formation in Staphylococcus epidermidis strains, which cause very important problems such as implant-associated infections in hospitalized and immunocompromised patients worldwide.  Materials and methods: The effects of varying concentrations of NAC on the formation of biofilm by 28 strains of Staphylococcus epidermidis was investigated spectrophotometrically by micro-ELISA assay.  Results: Significant differences in biofilm formation in the presence of various NAC concentrations were found in 15 methicillin-resistant Staphylococcus epidermidis and 13 methicillin-sensitive Staphylococcus epidermidis strains (P < 0.05).    Conclusion: It was found that slime formation was decreased due to the increased concentrations of the NAC treatments. Based on these findings, it is possible to use NAC as an antibiofilm agent on medical devices or in catheter lock solutions to prevent colonization and implant-associated infections.

 

Aim: To examine the possible preventive effect of N-acetylcysteine (NAC) on biofilm formation in Staphylococcus epidermidis strains, which cause very important problems such as implant-associated infections in hospitalized and immunocompromised patients worldwide.  Materials and methods: The effects of varying concentrations of NAC on the formation of biofilm by 28 strains of Staphylococcus epidermidis was investigated spectrophotometrically by micro-ELISA assay.  Results: Significant differences in biofilm formation in the presence of various NAC concentrations were found in 15 methicillin-resistant Staphylococcus epidermidis and 13 methicillin-sensitive Staphylococcus epidermidis strains (P < 0.05).    Conclusion: It was found that slime formation was decreased due to the increased concentrations of the NAC treatments. Based on these findings, it is possible to use NAC as an antibiofilm agent on medical devices or in catheter lock solutions to prevent colonization and implant-associated infections.

Article Details

The effect of N-acetylcysteine on growth and biofilm formation in Staphylococcus epidermidis strains

Authors:

Sahra KIRMUSAOĞLU | Seyhun YURDUGÜL | M. Esra KOÇOĞLU

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2012 Vol.42 Issue 4, pp.689-694

Document Type:

Article

Publication Date:

3/2012

Document Language:

Turkish

Document ID (Org No.):

2000754116

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Staphylococcus epidermidis

biofilm formation

indwelling device-associated infections

N-acetylcysteine

Issues

Article Details

The effect of N-acetylcysteine on growth and biofilm formation in Staphylococcus epidermidis strains

Authors: Sahra KIRMUSAOĞLU | Seyhun YURDUGÜL | M. Esra KOÇOĞLU

Publisher: TUBITAK

Journal: Turkish Journal of Medical Sciences 2012 Vol.42 Issue 4, pp.689-694

Document Type: Article

Publication Date: 3/2012

Document Language: Turkish

Document ID (Org No.): 2000754116

Frequency: Bimonthly

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Staphylococcus epidermidis

biofilm formation

indwelling device-associated infections

N-acetylcysteine

Issues

Authors:

Sahra KIRMUSAOĞLU | Seyhun YURDUGÜL | M. Esra KOÇOĞLU

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2012 Vol.42 Issue 4, pp.689-694

Document Type:

Article

Publication Date:

3/2012

Document Language:

Turkish

Document ID (Org No.):

2000754116

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144