Plasma Dopamine Level as a Biomarker for Pain in Myofascial Temporomandibular Disorders

Kamal T. A Al-Ghllabi; Khaldon T. S. A Al-Buriahy; Ahmed A.  Al-Hammadi; Sarah A. A. Al-Zamzami; Omar A. S. A. Abdulmajeed; Asma Hasan Farhan; Khlood Saif Al-amery; Sarah Hamza Abdo; Hani Abdulmalik Alezzi; Ahmed Abdulfattah Al-Hammadi

Article Details

Plasma Dopamine Level as a Biomarker for Pain in Myofascial Temporomandibular Disorders

Authors:

Kamal T. A Al-Ghllabi | Khaldon T. S. A Al-Buriahy | Ahmed A. Al-Hammadi | Sarah A. A. Al-Zamzami | Omar A. S. A. Abdulmajeed | Asma Hasan Farhan | Khlood Saif Al-amery | Sarah Hamza Abdo | Hani Abdulmalik Alezzi | Ahmed Abdulfattah Al-Hammadi

Publisher:

University of Science and Technology, Yemen

Journal:

Yemeni Journal for Medical Sciences Vol.19 Issue 8, pp.0-0

Document Type:

Article

Publication Date:

1/2025

Document Language:

English

Document ID (Org No.):

2001538963

pISSN:

2227-961X

Keywords:

Abstract:

 Background: Myofascial Temporomandibular Disorders (M-TMD) are characterized by chronic pain and dysfunction of the jaw muscles, often linked to stress and neurochemical imbalances. Dopamine, a neurotransmitter involved in pain modulation, has been proposed as a potential biomarker for M-TMD-related pain. This study aimed to evaluate plasma dopamine levels in M-TMD patients compared to healthy controls and explore its role as a pain biomarker.
Objective: The primary objective was to assess plasma dopamine levels in M-TMD patients and correlate them with clinical pain symptoms.
Methods: A case-control study was conducted with 50 participants (25 M-TMD patients and 25 age- and sex-matched healthy controls). Blood samples were collected in EDTA tubes, centrifuged at 2000 g for 10 minutes, and plasma was stored at −60°C. Dopamine levels were measured in nM. Clinical data, including age, gender, symptoms, and OPG findings, were recorded. Statistical analysis included mean comparisons (t-test) and subgroup analysis by gender and age.
Results: Plasma dopamine levels were significantly higher in M-TMD patients (mean: 5.01 nM) compared to controls (mean: 2.53 nM; p < 0.001). Female M-TMD patients had slightly higher dopamine levels (mean: 5.12 nM) than males (mean: 4.89 nM), though not statistically significant (p = 0.23). Common symptoms in M-TMD patients included bruxism (44%), morning jaw stiffness (40%), and stress-related jaw tension (56%). All patients exhibited mild condylar flattening on OPG, and no significant correlation was found between dopamine levels and age (r = 0.12, p = 0.34).
Conclusion: Elevated plasma dopamine levels in M-TMD patients suggest its potential role as a biomarker for pain and stress-related pathophysiology. The findings support further investigation into dopaminergic pathways in M-TMD and personalized treatment strategies targeting neurochemical imbalances.

Article Details

Plasma Dopamine Level as a Biomarker for Pain in Myofascial Temporomandibular Disorders

Authors:

Kamal T. A Al-Ghllabi | Khaldon T. S. A Al-Buriahy | Ahmed A. Al-Hammadi | Sarah A. A. Al-Zamzami | Omar A. S. A. Abdulmajeed | Asma Hasan Farhan | Khlood Saif Al-amery | Sarah Hamza Abdo | Hani Abdulmalik Alezzi | Ahmed Abdulfattah Al-Hammadi

Publisher:

University of Science and Technology, Yemen

Journal:

Yemeni Journal for Medical Sciences Vol.19 Issue 8, pp.0-0

Document Type:

Article

Publication Date:

1/2025

Document Language:

English

Document ID (Org No.):

2001538963

pISSN:

2227-961X

Plasma dopamine

biomarker

myofascial temporomandibular disorders (M-TMD/TMD)

chronic orofacial pain modulation

Neurochemical imbalance

DC/TMD (Diagnostic Criteria for TMD)

HPLC-ECD

stress-related jaw dysfunction

Issues

Article Details

Authors: Kamal T. A Al-Ghllabi | Khaldon T. S. A Al-Buriahy | Ahmed A. Al-Hammadi | Sarah A. A. Al-Zamzami | Omar A. S. A. Abdulmajeed | Asma Hasan Farhan | Khlood Saif Al-amery | Sarah Hamza Abdo | Hani Abdulmalik Alezzi | Ahmed Abdulfattah Al-Hammadi

Publisher: University of Science and Technology, Yemen

Journal: Yemeni Journal for Medical Sciences Vol.19 Issue 8, pp.0-0

Document Type: Article

Publication Date: 1/2025

Document Language: English

Document ID (Org No.): 2001538963

pISSN: 2227-961X

Issues

Authors:

Kamal T. A Al-Ghllabi | Khaldon T. S. A Al-Buriahy | Ahmed A. Al-Hammadi | Sarah A. A. Al-Zamzami | Omar A. S. A. Abdulmajeed | Asma Hasan Farhan | Khlood Saif Al-amery | Sarah Hamza Abdo | Hani Abdulmalik Alezzi | Ahmed Abdulfattah Al-Hammadi

Publisher:

University of Science and Technology, Yemen

Journal:

Yemeni Journal for Medical Sciences Vol.19 Issue 8, pp.0-0

Document Type:

Article

Publication Date:

1/2025

Document Language:

English

Document ID (Org No.):

2001538963

pISSN:

2227-961X