Determination of Anti-Spike S1 RBD IgG Values in Healthcare Workers with Inactivated SARS-CoV-2 Vaccine

Kardelen Bülbül; Taylan Bozok; Hamide Kaya; Harun Gülbudak; Seda Tezcan Ülger; Gönül Aslan

Article Details

Determination of Anti-Spike S1 RBD IgG Values in Healthcare Workers with Inactivated SARS-CoV-2 Vaccine

Authors:

Kardelen Bülbül | Taylan Bozok | Hamide Kaya | Harun Gülbudak | Seda Tezcan Ülger | Gönül Aslan

Publisher:

Karyay Karadeniz Yayımcılık

Main Topics:

Farmasotik Mikrobiyoloji

Journal:

Black Sea Journal of Health Science Vol.7 Issue 2, pp.93-97

Document Type:

Article

Publication Date:

1/2024

Document Language:

Turkish

Document ID (Org No.):

2001311726

pISSN:

2619-9041

Keywords:

Abstract:

 Various vaccines have been developed to combat the disease and its complications during the COVID-19 pandemic. Our study aimed to determine COVID-19 antibody titers in healthcare workers who received two doses of Coronavac Sinovac vaccine. Access SARS-CoV-2 IgG test Beckman was performed on blood samples taken from 186 volunteer healthcare workers who received two doses of Coronavac vaccine at Mersin University Hospital between March and September 2021. Antibody titers were determined by ELISA-based testing. Of the 186 participants included in the study, 47.8 n  89 were male and 52.2 n  97 were female. The average age is 42.38.7 23-60. A significant difference was detected between the positivity rates of participants aged 40 and under and participants over 40 years of age 40; 68.1, 40; 43.6, P0.001. It was observed that the group with the highest positive antibody titer was the 21-30 age groups. It was determined that antibody levels decreased significantly with increasing age r-0.203, P0.005. There were 22 participants with comorbidities. No significant difference was observed in terms of antibody titer in patients with comorbidities compared to healthy individuals. Since our study was a short-term project, it was conducted with a small number of participants. More comprehensive studies are needed.

 Various vaccines have been developed to combat the disease and its complications during the COVID-19 pandemic. Our study aimed to determine COVID-19 antibody titers in healthcare workers who received two doses of Coronavac Sinovac vaccine. Access SARS-CoV-2 IgG test Beckman was performed on blood samples taken from 186 volunteer healthcare workers who received two doses of Coronavac vaccine at Mersin University Hospital between March and September 2021. Antibody titers were determined by ELISA-based testing. Of the 186 participants included in the study, 47.8 n  89 were male and 52.2 n  97 were female. The average age is 42.38.7 23-60. A significant difference was detected between the positivity rates of participants aged 40 and under and participants over 40 years of age 40; 68.1, 40; 43.6, P0.001. It was observed that the group with the highest positive antibody titer was the 21-30 age groups. It was determined that antibody levels decreased significantly with increasing age r-0.203, P0.005. There were 22 participants with comorbidities. No significant difference was observed in terms of antibody titer in patients with comorbidities compared to healthy individuals. Since our study was a short-term project, it was conducted with a small number of participants. More comprehensive studies are needed.

 Various vaccines have been developed to combat the disease and its complications during the COVID-19 pandemic. Our study aimed to determine COVID-19 antibody titers in healthcare workers who received two doses of Coronavac Sinovac vaccine. Access SARS-CoV-2 IgG test Beckman was performed on blood samples taken from 186 volunteer healthcare workers who received two doses of Coronavac vaccine at Mersin University Hospital between March and September 2021. Antibody titers were determined by ELISA-based testing. Of the 186 participants included in the study, 47.8 n  89 were male and 52.2 n  97 were female. The average age is 42.38.7 23-60. A significant difference was detected between the positivity rates of participants aged 40 and under and participants over 40 years of age 40; 68.1, 40; 43.6, P0.001. It was observed that the group with the highest positive antibody titer was the 21-30 age groups. It was determined that antibody levels decreased significantly with increasing age r-0.203, P0.005. There were 22 participants with comorbidities. No significant difference was observed in terms of antibody titer in patients with comorbidities compared to healthy individuals. Since our study was a short-term project, it was conducted with a small number of participants. More comprehensive studies are needed.

 COVID-19 pandemisi sırasında hastalık ve komplikasyonlarıyla mücadele amacıyla çeşitli aşılar geliştirilmiştir. Çalışmamızda iki doz Coronavac Sinovac aşısı uygulanmış sağlık çalışanlarında COVID-19 antikor titrelerinin belirlenmesi amaçlanmıştır. Mart- Eylül 2021 tarihleri arasında Mersin Üniversitesi Hastanesinde gönüllü sağlık çalışanlarından iki doz Coronavac aşısı uygulanan 186 kişiden alınan kan örneklerinden Access SARS-CoV-2 IgG testi Beckman uygulandı. Antikor titreleri ELISA temelli test ile tespit edildi. Çalışmaya dahil edilen 186 katılımcının 47,8i n89 erkek, 52,2si n97 kadındır. Yaş ortalaması 42,38,7 23-60 tür. 40 yaş ve altı katılımcılar ile 40 yaş üzeri katılımcıların pozitiflik oranları arasında anlamlı farklılık tespit edildi 40; 68,1, 40; 43,6, P0,001. En fazla pozitif antikor titresi olan grup 21-30 yaş grubu olduğu görüldü. Yaş artışı ile birlikte antikor düzeyleri anlamlı şekilde azaldığı belirlendi r-0.203, P0,001. Ek hastalığı olan 22 katılımcı vardır. Ek hastalığı olanlarda, sağlıklı olanlara göre antikor titresi açısından anlamlı farklılık gözlenmedi. Çalışmamız kısa süreli bir proje olduğu için az sayıda katılımcı ile yapılmıştır. Daha geniş kapsamlı yapılacak çalışmalara ihtiyaç vardır.

Article Details

Determination of Anti-Spike S1 RBD IgG Values in Healthcare Workers with Inactivated SARS-CoV-2 Vaccine

Authors:

Kardelen Bülbül | Taylan Bozok | Hamide Kaya | Harun Gülbudak | Seda Tezcan Ülger | Gönül Aslan

Publisher:

Karyay Karadeniz Yayımcılık

Main Topics:

Farmasotik Mikrobiyoloji

Journal:

Black Sea Journal of Health Science Vol.7 Issue 2, pp.93-97

Document Type:

Article

Publication Date:

1/2024

Document Language:

Turkish

Document ID (Org No.):

2001311726

pISSN:

2619-9041

COVID-19

Inactivated vaccine

AntibodyCOVID-19

İnaktif aşı

Antikor

Issues

Article Details

Determination of Anti-Spike S1 RBD IgG Values in Healthcare Workers with Inactivated SARS-CoV-2 Vaccine

Authors: Kardelen Bülbül | Taylan Bozok | Hamide Kaya | Harun Gülbudak | Seda Tezcan Ülger | Gönül Aslan

Publisher: Karyay Karadeniz Yayımcılık

Main Topics: Farmasotik Mikrobiyoloji

Journal: Black Sea Journal of Health Science Vol.7 Issue 2, pp.93-97

Document Type: Article

Publication Date: 1/2024

Document Language: Turkish

Document ID (Org No.): 2001311726

pISSN: 2619-9041

COVID-19

Inactivated vaccine

AntibodyCOVID-19

İnaktif aşı

Antikor

Issues

Authors:

Kardelen Bülbül | Taylan Bozok | Hamide Kaya | Harun Gülbudak | Seda Tezcan Ülger | Gönül Aslan

Publisher:

Karyay Karadeniz Yayımcılık

Main Topics:

Farmasotik Mikrobiyoloji

Journal:

Black Sea Journal of Health Science Vol.7 Issue 2, pp.93-97

Document Type:

Article

Publication Date:

1/2024

Document Language:

Turkish

Document ID (Org No.):

2001311726

pISSN:

2619-9041