Immune response to type-2 porcine circovirus in weaned pigs

Hong CHEN; Ke-Ying ZHANG; Xue-Mei DING; Zhi-Wen XU; Dai-Wen CHEN; Gang TIAN

Article Details

Immune response to type-2 porcine circovirus in weaned pigs

Authors:

Hong CHEN | Ke-Ying ZHANG | Xue-Mei DING | Zhi-Wen XU | Dai-Wen CHEN | Gang TIAN

Publisher:

TUBITAK

Journal:

Turkish Journal of Veterinary and Animal Sciences 2010 Vol.34 Issue 2, pp.173-179

Document Type:

Article

Publication Date:

1/2010

Document Language:

Turkish

Document ID (Org No.):

2000767527

Frequency:

Bimonthly

eISSN:

1303-6181

pISSN:

1300-0128

Keywords:

Abstract:

 

Sixteen crossbred barrows (Duroc × Landrace × Yorkshire) weaned at 28 days with an initial body weight of 5.12-8.64 kg and no antibodies to PCV2 were used in a 5-week trial to evaluate the immune response after intranasal inoculation with type-2 porcine circovirus. The percentage of peripheral blood ANAE+ T cells, PCV2 antibody titer, immunoglobulins, and serum IFN-g, IL-2, and sIL-2R levels were determined. The results show that the percentage of peripheral blood ANAE+ T cells was notably higher in inoculated pigs 5 days post-inoculation (dpi) and significantly lower 21 dpi than in the control group. The anti-PCV2 titer in the inoculated group was significantly higher than that in the control group 14 dpi. The immunoglobulin profile of the 2 groups also differed. The IFN-g level in the inoculated group decreased significantly from 7 to 28 dpi, as compared with the control group. The results suggest that PCV2 challenge results in an immune system response.

 

Sixteen crossbred barrows (Duroc × Landrace × Yorkshire) weaned at 28 days with an initial body weight of 5.12-8.64 kg and no antibodies to PCV2 were used in a 5-week trial to evaluate the immune response after intranasal inoculation with type-2 porcine circovirus. The percentage of peripheral blood ANAE+ T cells, PCV2 antibody titer, immunoglobulins, and serum IFN-g, IL-2, and sIL-2R levels were determined. The results show that the percentage of peripheral blood ANAE+ T cells was notably higher in inoculated pigs 5 days post-inoculation (dpi) and significantly lower 21 dpi than in the control group. The anti-PCV2 titer in the inoculated group was significantly higher than that in the control group 14 dpi. The immunoglobulin profile of the 2 groups also differed. The IFN-g level in the inoculated group decreased significantly from 7 to 28 dpi, as compared with the control group. The results suggest that PCV2 challenge results in an immune system response.

Article Details

Immune response to type-2 porcine circovirus in weaned pigs

Authors:

Hong CHEN | Ke-Ying ZHANG | Xue-Mei DING | Zhi-Wen XU | Dai-Wen CHEN | Gang TIAN

Publisher:

TUBITAK

Journal:

Turkish Journal of Veterinary and Animal Sciences 2010 Vol.34 Issue 2, pp.173-179

Document Type:

Article

Publication Date:

1/2010

Document Language:

Turkish

Document ID (Org No.):

2000767527

Frequency:

Bimonthly

eISSN:

1303-6181

pISSN:

1300-0128

Key words: Immune response

type-2 porcine circovirus

weaning piglets

Issues

Article Details

Immune response to type-2 porcine circovirus in weaned pigs

Authors: Hong CHEN | Ke-Ying ZHANG | Xue-Mei DING | Zhi-Wen XU | Dai-Wen CHEN | Gang TIAN

Publisher: TUBITAK

Journal: Turkish Journal of Veterinary and Animal Sciences 2010 Vol.34 Issue 2, pp.173-179

Document Type: Article

Publication Date: 1/2010

Document Language: Turkish

Document ID (Org No.): 2000767527

Frequency: Bimonthly

eISSN: 1303-6181

pISSN: 1300-0128

Key words: Immune response

type-2 porcine circovirus

weaning piglets

Issues

Authors:

Hong CHEN | Ke-Ying ZHANG | Xue-Mei DING | Zhi-Wen XU | Dai-Wen CHEN | Gang TIAN

Publisher:

TUBITAK

Journal:

Turkish Journal of Veterinary and Animal Sciences 2010 Vol.34 Issue 2, pp.173-179

Document Type:

Article

Publication Date:

1/2010

Document Language:

Turkish

Document ID (Org No.):

2000767527

Frequency:

Bimonthly

eISSN:

1303-6181

pISSN:

1300-0128