Severe bone marrow suppression following single-dose methotrexate treatment for ectopic pregnancy

Betül DÜNDAR; Burcu DİNÇGEZ ÇAKMAK; Gülten ÖZGEN; Fatma KETENCİ GENCER; Burcu AYDIN BOYAMA

doi:https://doi.org/10.18621/eurj.304373

Article Details

Severe bone marrow suppression following single-dose methotrexate treatment for ectopic pregnancy

Authors:

Betül DÜNDAR | Burcu DİNÇGEZ ÇAKMAK | Gülten ÖZGEN | Fatma KETENCİ GENCER | Burcu AYDIN BOYAMA

Publisher:

Prusa Medical Publishing

Main Topics:

Promotion of health

Journal:

The European Research Journal 2017 Vol.3 Issue 3, pp.285-289

Document Type:

Article

Publication Date:

11/2017

Document Language:

Turkish

Document ID (Org No.):

2000663366

Frequency:

Bimonthly

eISSN:

2149-3189

DOI:

https://doi.org/10.18621/eurj.304373

Abstract:

 


Methotrexate is associated with multisystem side
effects which depend on the dosage, route of administration and length of
treatment. Bone marrow suppression is a very rare but one of the most mortal
complications. A case of severe bone marrow suppression following single dose
methotrexate for ectopic pregnancy was presented in this study. A 33-year-old woman,
diagnosed as ectopic pregnancy, was given single-dose intramuscular methotrexate
of 50 mg/m². On 10th day patient was admitted with lethargy,
irritability, vomiting, hematemesis, diarrhea, oral mucositis and skin rash.
Laboratory findings revealed severe bone marrow suppression. Supportive
treatment together with antibacterial/ antifungal drugs and granulocyte colony
stimulating factors were administered. On the 3rd day of treatment,
mucositis and oral intake began to improve. After 1 week complete blood count
was normal. Methotrexate may have mortal clinical consequences even with very
low doses. Therefore, a careful patient history for patient selection and
closer clinical follow-up are essential. 


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Article Details

Severe bone marrow suppression following single-dose methotrexate treatment for ectopic pregnancy

Authors: Betül DÜNDAR | Burcu DİNÇGEZ ÇAKMAK | Gülten ÖZGEN | Fatma KETENCİ GENCER | Burcu AYDIN BOYAMA

Publisher: Prusa Medical Publishing

Main Topics: Promotion of health

Journal: The European Research Journal 2017 Vol.3 Issue 3, pp.285-289

Document Type: Article

Publication Date: 11/2017

Document Language: Turkish

Document ID (Org No.): 2000663366

Frequency: Bimonthly

eISSN: 2149-3189

DOI: https://doi.org/10.18621/eurj.304373

Issues

Authors:

Betül DÜNDAR | Burcu DİNÇGEZ ÇAKMAK | Gülten ÖZGEN | Fatma KETENCİ GENCER | Burcu AYDIN BOYAMA

Publisher:

Prusa Medical Publishing

Main Topics:

Promotion of health

Journal:

The European Research Journal 2017 Vol.3 Issue 3, pp.285-289

Document Type:

Article

Publication Date:

11/2017

Document Language:

Turkish

Document ID (Org No.):

2000663366

Frequency:

Bimonthly

eISSN:

2149-3189

DOI:

https://doi.org/10.18621/eurj.304373