The isolation of bioactive compounds from Warburgia ugandensis bark: A report of albicanyl acetate, caseamemin and β-sitosterol from Warburgia species

Zelalem Gizachew

Article Details

The isolation of bioactive compounds from Warburgia ugandensis bark: A report of albicanyl acetate, caseamemin and β-sitosterol from Warburgia species

Authors:

Zelalem Gizachew

Publisher:

İzzet KARA

Main Topics:

Natural Products and Bioactive Compounds

Journal:

International Journal of Secondary Metabolite Vol.11 Issue 4, pp.710-721

Document Type:

Article

Publication Date:

3/2024

Document Language:

English

Document ID (Org No.):

2001326688

pISSN:

2148-6905

Keywords:

Abstract:

 Warburgia ugandensis, which is one of the indigenous species of Ethiopia, is known for its wide range of biological activities. A series of drimane sesquiterpenoids have been isolated from the stem bark of the plant. However, there is no report on the herbicidal potential of the plant against invasive weeds like Parthenium hysterophorus. In this study, the herbicidal potential of W. ugandensis against the P. hysterophorus weed was investigated. Following the bioassay protocol, muzigadial as powerful phytotoxic compound together with other eight compounds were isolated from the EtOAc soluble portion of the ethanol extract of the bark of the plant. These compounds were identified using different physical and spectroscopic methods. The isolated compounds are albicanyl acetate 35, caseamemin 36, β-sitosterol 37, muzigadial 38, cinnamolide-3β-acetate 39, ugandensidial 40, 11α-hydroxy muzigadiolide 41, polygodial 42 and 9-deoxymuzigadial 43. The first three compounds are new to the species W. ugandensis. Furthermore, two other compounds namely heptacosanol 44 and hentriacontane 45 were also isolated from this species. In summary, the purpose of this study, to the best of my knowledge, is to provide the three initially identified compounds from the plant material and provide information on the plants potential utility in agricultural applications.

 Warburgia ugandensis, which is one of the indigenous species of Ethiopia, is known for its wide range of biological activities. A series of drimane sesquiterpenoids have been isolated from the stem bark of the plant. However, there is no report on the herbicidal potential of the plant against invasive weeds like Parthenium hysterophorus. In this study, the herbicidal potential of W. ugandensis against the P. hysterophorus weed was investigated. Following the bioassay protocol, muzigadial as powerful phytotoxic compound together with other eight compounds were isolated from the EtOAc soluble portion of the ethanol extract of the bark of the plant. These compounds were identified using different physical and spectroscopic methods. The isolated compounds are albicanyl acetate 35, caseamemin 36, β-sitosterol 37, muzigadial 38, cinnamolide-3β-acetate 39, ugandensidial 40, 11α-hydroxy muzigadiolide 41, polygodial 42 and 9-deoxymuzigadial 43. The first three compounds are new to the species W. ugandensis. Furthermore, two other compounds namely heptacosanol 44 and hentriacontane 45 were also isolated from this species. In summary, the purpose of this study, to the best of my knowledge, is to provide the three initially identified compounds from the plant material and provide information on the plants potential utility in agricultural applications.

 Warburgia ugandensis, which is one of the indigenous species of Ethiopia, is known for its wide range of biological activities. A series of drimane sesquiterpenoids have been isolated from the stem bark of the plant. However, there is no report on the herbicidal potential of the plant against invasive weeds like Parthenium hysterophorus. In this study, the herbicidal potential of W. ugandensis against the P. hysterophorus weed was investigated. Following the bioassay protocol, muzigadial as powerful phytotoxic compound together with other eight compounds were isolated from the EtOAc soluble portion of the ethanol extract of the bark of the plant. These compounds were identified using different physical and spectroscopic methods. The isolated compounds are albicanyl acetate 35, caseamemin 36, β-sitosterol 37, muzigadial 38, cinnamolide-3β-acetate 39, ugandensidial 40, 11α-hydroxy muzigadiolide 41, polygodial 42 and 9-deoxymuzigadial 43. The first three compounds are new to the species W. ugandensis. Furthermore, two other compounds namely heptacosanol 44 and hentriacontane 45 were also isolated from this species. In summary, the purpose of this study, to the best of my knowledge, is to provide the three initially identified compounds from the plant material and provide information on the plants potential utility in agricultural applications.

 Warburgia ugandensis, which is one of the indigenous species of Ethiopia, is known for its wide range of biological activities. A series of drimane sesquiterpenoids have been isolated from the stem bark of the plant. However, there is no report on the herbicidal potential of the plant against invasive weeds like Parthenium hysterophorus. In this study, the herbicidal potential of W. ugandensis against the P. hysterophorus weed was investigated. Following the bioassay protocol, muzigadial as powerful phytotoxic compound together with other eight compounds were isolated from the EtOAc soluble portion of the ethanol extract of the bark of the plant. These compounds were identified using different physical and spectroscopic methods. The isolated compounds are albicanyl acetate 35, caseamemin 36, β-sitosterol 37, muzigadial 38, cinnamolide-3β-acetate 39, ugandensidial 40, 11α-hydroxy muzigadiolide 41, polygodial 42 and 9-deoxymuzigadial 43. The first three compounds are new to the species W. ugandensis. Furthermore, two other compounds namely heptacosanol 44 and hentriacontane 45 were also isolated from this species. In summary, the purpose of this study, to the best of my knowledge, is to provide the three initially identified compounds from the plant material and provide information on the plants potential utility in agricultural applications.

Article Details

The isolation of bioactive compounds from Warburgia ugandensis bark: A report of albicanyl acetate, caseamemin and β-sitosterol from Warburgia species

Authors:

Zelalem Gizachew

Publisher:

İzzet KARA

Main Topics:

Natural Products and Bioactive Compounds

Journal:

International Journal of Secondary Metabolite Vol.11 Issue 4, pp.710-721

Document Type:

Article

Publication Date:

3/2024

Document Language:

English

Document ID (Org No.):

2001326688

pISSN:

2148-6905

Warburgia ugandensis

Albicanyl acetate

Caseamemin

Isolation

Phytotoxic activityWarburgia ugandensis

Albicanyl acetate

Caseamemin

Isolation

Phytotoxic activity

Issues

Article Details

Authors: Zelalem Gizachew

Publisher: İzzet KARA

Main Topics: Natural Products and Bioactive Compounds

Journal: International Journal of Secondary Metabolite Vol.11 Issue 4, pp.710-721

Document Type: Article

Publication Date: 3/2024

Document Language: English

Document ID (Org No.): 2001326688

pISSN: 2148-6905

Issues

Authors:

Zelalem Gizachew

Publisher:

İzzet KARA

Main Topics:

Natural Products and Bioactive Compounds

Journal:

International Journal of Secondary Metabolite Vol.11 Issue 4, pp.710-721

Document Type:

Article

Publication Date:

3/2024

Document Language:

English

Document ID (Org No.):

2001326688

pISSN:

2148-6905