Antimicrobial Screening of 2-Methyl-3- Acyl-4-Aryl-2,6,6 and / or 2,7,7-Trimethyl1,4,5,6,7,8-Hexahydroquinoline Derivatives

Miyase Gözde GÜNDÜZ; Melike EKİZOĞLU; Didem KART; Rahime ŞİMŞEK; Cihat ŞAFAK

Article Details

Antimicrobial Screening of 2-Methyl-3- Acyl-4-Aryl-2,6,6 and / or 2,7,7-Trimethyl1,4,5,6,7,8-Hexahydroquinoline Derivatives

Authors:

Miyase Gözde GÜNDÜZ | Melike EKİZOĞLU | Didem KART | Rahime ŞİMŞEK | Cihat ŞAFAK

Publisher:

Hacettepe University

Main Topics:

Pharmacology and therapeutics

Journal:

Hacettepe University Journal of the Faculty of Pharmacy 2011 Issue 1, pp.51-58

Document Type:

Article

Publication Date:

12/2010

Document Language:

English

Document ID (Org No.):

2000454401

Frequency:

Quarterly

eISSN:

2458-8806

Abstract:

 

In this study, thirty compounds having methyl ethyl  2,6,6- or  2,7,7-trimethyl-5-oxo-4- difluorosubstituted phenyl -1,4,5,6,7,8-hexahydroquinoline-  3-carboxylate and N,N-diethyl-2,6,6- or 2,7,7-trimethyl-  5-oxo-4- difluorosubstituted phenyl -1,4,5,6,7,8-hexahydroquinoline-3-  carboxamide structure, have been screened for their antimicrobial activities.  Antimicrobial activities were determined as minimum inhibitory  concentration  MIC  values by broth microdilution method against bacteria  and fungi.

 

Bu çalışmada metil etil  2,6,6- veya 2,7,7-trimetil-5-okso-4-   difluorosübstitüe fenil -1,4,5,6,7,8-hekzahidrokinolin-3-karboksilat  ve N,N-dietil-2,6,6- veya 2,7,7-trimetil-5-okso-4- difluorosübstitüe  fenil -1,4,5,6,7,8-hekzahidrokinolin-3-karboksamit yapısına sahip otuz  bileşiğin antimikrobiyal aktivitesi taranmıştır. Bakteri ve funguslara karşı  antimikrobiyal aktiviteleri broth mikrodilüsyon yöntemi kullanılarak  minimum inhibitör konsantrasyonu  MIC  olarak saptanmıştır.

Article Details

Antimicrobial Screening of 2-Methyl-3- Acyl-4-Aryl-2,6,6 and / or 2,7,7-Trimethyl1,4,5,6,7,8-Hexahydroquinoline Derivatives

Authors: Miyase Gözde GÜNDÜZ | Melike EKİZOĞLU | Didem KART | Rahime ŞİMŞEK | Cihat ŞAFAK

Publisher: Hacettepe University

Main Topics: Pharmacology and therapeutics

Journal: Hacettepe University Journal of the Faculty of Pharmacy 2011 Issue 1, pp.51-58

Document Type: Article

Publication Date: 12/2010

Document Language: English

Document ID (Org No.): 2000454401

Frequency: Quarterly

eISSN: 2458-8806

Issues

Authors:

Miyase Gözde GÜNDÜZ | Melike EKİZOĞLU | Didem KART | Rahime ŞİMŞEK | Cihat ŞAFAK

Publisher:

Hacettepe University

Main Topics:

Pharmacology and therapeutics

Journal:

Hacettepe University Journal of the Faculty of Pharmacy 2011 Issue 1, pp.51-58

Document Type:

Article

Publication Date:

12/2010

Document Language:

English

Document ID (Org No.):

2000454401

Frequency:

Quarterly

eISSN:

2458-8806