Stress Urinary Incontinence in a Higher Animal Model

Sherif Badra; Mahmoud Ahmed; Youssef Kotb; James Yoo; Sherif Mourad

doi:10.12816/0013865

Article Details

Stress Urinary Incontinence in a Higher Animal Model

Authors:

Sherif Badra | Mahmoud Ahmed | Youssef Kotb | James Yoo | Sherif Mourad

Publisher:

Ain Shams Clinical and Scientific Society

Main Topics:

Medicine

Journal:

Ain Shams Medical Journal 2013 Vol.64 Issue 4-6, pp.231-236

Document Type:

Article

Publication Date:

6/2013

Document Language:

English

Document ID (Org No.):

68850

Frequency:

Quarterly

pISSN:

00022144

DOI:

10.12816/0013865

Descriptors:

Abstract:

 Background. Current treatment modalities for stress urinaryincontinence have limitations. Female nonhuman primates are verysimilar to human regarding the anatomy, physiology, lower urinarytract structure, and bipedal posture. They can be used to test differentinterventions for treatment of sphincter deficiency.
Aim. To develop a model of injury to the urethral sphincter.
Materials and Methods: The injury model was produced in 19 adult female Cynomolgus monkeys by cutting pudendal nerve. Urodynamic studies, before and during pudendal nerve stimulation, were done before injury and 3, 6 and 12 months post injury. Additionally, CT cystourethrography and sphincter structure was analyzed at these time-points.Current treatment modalities for stress urinary incontinence have limitations. Female nonhuman primates are very similar to human regarding the anatomy, physiology, lower urinary tract structure, and bipedal posture. They can be used to test different interventions for treatment of sphincter deficiency..

Results: Pudendal nerve transection reduced the maximal urethral pressure by half its value for a year post injury. These results were consistent with decreased muscle content of the urethral sphincter, and reduced nerve expression.
Conclusion: This model may serve as a highly translatable animal model to test the efficacy and safety of treatments for urinary incontinence.

Article Details

Stress Urinary Incontinence in a Higher Animal Model

Authors:

Sherif Badra | Mahmoud Ahmed | Youssef Kotb | James Yoo | Sherif Mourad

Publisher:

Ain Shams Clinical and Scientific Society

Main Topics:

Medicine

Journal:

Ain Shams Medical Journal 2013 Vol.64 Issue 4-6, pp.231-236

Document Type:

Article

Publication Date:

6/2013

Document Language:

English

Document ID (Org No.):

68850

Frequency:

Quarterly

pISSN:

00022144

DOI:

10.12816/0013865

Descriptors:

URINATION DISORDERS

URINARY TRACT DISEASES

FUNCTIONAL DISORDERS

SPHINCTERS

THERAPY

UROLOGY

ANIMALS

Issues

Article Details

Authors: Sherif Badra | Mahmoud Ahmed | Youssef Kotb | James Yoo | Sherif Mourad

Publisher: Ain Shams Clinical and Scientific Society

Main Topics: Medicine

Journal: Ain Shams Medical Journal 2013 Vol.64 Issue 4-6, pp.231-236

Document Type: Article

Publication Date: 6/2013

Document Language: English

Document ID (Org No.): 68850

Frequency: Quarterly

pISSN: 00022144

DOI: 10.12816/0013865

Descriptors:

Issues

Authors:

Sherif Badra | Mahmoud Ahmed | Youssef Kotb | James Yoo | Sherif Mourad

Publisher:

Ain Shams Clinical and Scientific Society

Main Topics:

Medicine

Journal:

Ain Shams Medical Journal 2013 Vol.64 Issue 4-6, pp.231-236

Document Type:

Article

Publication Date:

6/2013

Document Language:

English

Document ID (Org No.):

68850

Frequency:

Quarterly

pISSN:

00022144

DOI:

10.12816/0013865