Survival and Mediation Analysis with Correlated Frailty

Usha S Govindarajulu; Mohsin Qadri

Article Details

Survival and Mediation Analysis with Correlated Frailty

Authors:

Usha S Govindarajulu | Mohsin Qadri

Publisher:

Science Publications

Journal:

Current Research in Biostatistics Vol.9 Issue 1, pp.21-30

Document Type:

Article

Publication Date:

1/2019

Document Language:

English

Document ID (Org No.):

2001533862

pISSN:

2524-2229

Keywords:

Abstract:

 Many studies have focused on mediation effects, but fewer have focused on these in a time-to-event analysis and even fewer have focused on these effects in a survival model with frailty effects. The purpose of this study was to show unique modeling of correlated frailty effects with mediation and to demonstrate their use through simulations as well as on a real data application. We focused on a technique introduced by (Lange et al., 2012), which involves a procedure based on Marginal Structural Models (MSM) that directly parameterize the natural direct and indirect effects of interest. Using their method of specifying the MSM structure along with a correlated frailty model allowed us to incorporate the unexplained heterogeneity still unaccounted for by these models. We were able to ascertain direct and indirect mediating effects in the simulations. In the real dataset, we were also able to demonstrate stronger frailty effect in the correlated frailty model accounting for mediation.

Article Details

Survival and Mediation Analysis with Correlated Frailty

Authors:

Usha S Govindarajulu | Mohsin Qadri

Publisher:

Science Publications

Journal:

Current Research in Biostatistics Vol.9 Issue 1, pp.21-30

Document Type:

Article

Publication Date:

1/2019

Document Language:

English

Document ID (Org No.):

2001533862

pISSN:

2524-2229

Survival Analysis

Causal Mediation

Cox Model

Correlated Frailty

Heterogeniety

Issues

Article Details

Survival and Mediation Analysis with Correlated Frailty

Authors: Usha S Govindarajulu | Mohsin Qadri

Publisher: Science Publications

Journal: Current Research in Biostatistics Vol.9 Issue 1, pp.21-30

Document Type: Article

Publication Date: 1/2019

Document Language: English

Document ID (Org No.): 2001533862

pISSN: 2524-2229

Survival Analysis

Causal Mediation

Cox Model

Correlated Frailty

Heterogeniety

Issues

Authors:

Usha S Govindarajulu | Mohsin Qadri

Publisher:

Science Publications

Journal:

Current Research in Biostatistics Vol.9 Issue 1, pp.21-30

Document Type:

Article

Publication Date:

1/2019

Document Language:

English

Document ID (Org No.):

2001533862

pISSN:

2524-2229