Prevalence and Significance of Cytogenetic Findings of Acute Lymphoblastic Leukemia : Experience at King Hussein Medical Center

Maher Mustafa; Al-Jarrah , Omaiema; Nazmi Kamal; Asma Al-Abadi; Ayman Hallosh; Rawan Hamdan

doi:10.12816/0013179

Article Details

Prevalence and Significance of Cytogenetic Findings of Acute Lymphoblastic Leukemia : Experience at King Hussein Medical Center

Authors:

Maher Mustafa | Al-Jarrah , Omaiema | Nazmi Kamal | Asma Al-Abadi | Ayman Hallosh | Rawan Hamdan

Publisher:

Jordanian Medical services - Jordanian Armed Forces

Main Topics:

Medicine

Journal:

Journal of the Royal Medical Services 2015 Vol.22 Issue 3, pp.73-76

Document Type:

Article

Publication Date:

9/2015

Document Language:

English

Document ID (Org No.):

68008

Frequency:

Quarterly

eISSN:

20788711

pISSN:

20788703

DOI:

10.12816/0013179

Descriptors:

Keywords:

Abstract:

 
Objective: To determine the spectrum of cytogenetic abnormalities of acute lymphoblastic leukemia in children and adults at King Hussein Medical Center.
Methods: A retrospective review of raw bone marrow aspirate cytogenetic analysis reports was conducted at Princess Iman Research and Laboratory Sciences Center at King Hussein Medical Center during the period between Jan 2010 and Apr 2014. A total of 97 patients were studied regarding: age, gender, and cytogenetic analysis. The age was categorized into two groups (≤14 years as children group and >14 years as adult group). Descriptive analysis using frequencies was used to describe the study variables.
Results: Fifty-two (53.6%) cases were males and 45 (46.4%) were females. Their ages ranged between six months and 72 years. A total of 72 (74.2%) patients were children and 25 (25.8%) patients were > 14 years old. Of all pediatric acute lymphoblastic leukemia cases, 52.8% (38 cases) were negative for all the cytogenetic abnormalities, while 47.2% (34 cases) revealed one or more cytogenetic abnormalities. Translocation t(12;21), hyperdiploidy (>50 chromosomes or DNA index >1.16) were the predominant cytogenetic abnormalities in children with lymphoblastic leukemia. In the adult lymphoblastic leukemia group, 68.0% (17 cases) were negative for all the cytogenetic abnormalities, while 32% (8 cases) had cytogenetic abnormalities. Hyperdiploidy was the most common (20.0%, 5 patients) followed by translocation t (9;22) (8.0%, 2 patients).
Conclusion: Distribution and patterns of chromosomal abnormalities of lymphoblastic leukemia differ between children and adults. Translocation t(12;21), hyperdiploidy and rearrangements / translocations involving the MLL gene at chromosome 11q23 were the most commonly encountered in children. Hyperdiploidy was prevalent in adults, while no adult cases with 11q23 rearrangements or t(12;21) were encountered.

Article Details

Prevalence and Significance of Cytogenetic Findings of Acute Lymphoblastic Leukemia : Experience at King Hussein Medical Center

Authors:

Maher Mustafa | Al-Jarrah , Omaiema | Nazmi Kamal | Asma Al-Abadi | Ayman Hallosh | Rawan Hamdan

Publisher:

Jordanian Medical services - Jordanian Armed Forces

Main Topics:

Medicine

Journal:

Journal of the Royal Medical Services 2015 Vol.22 Issue 3, pp.73-76

Document Type:

Article

Publication Date:

9/2015

Document Language:

English

Document ID (Org No.):

68008

Frequency:

Quarterly

eISSN:

20788711

pISSN:

20788703

DOI:

10.12816/0013179

Descriptors:

CYTOGENETICS

ACUTE LYMPHOBLASTIC LEUKEMIA

BONE MARROW DISORDERS

HOSPITALS

JORDAN

Acute Lymphoblastic Leukemia

Bone Marrow Aspirate

Cytogenetics

Issues

Article Details

Authors: Maher Mustafa | Al-Jarrah , Omaiema | Nazmi Kamal | Asma Al-Abadi | Ayman Hallosh | Rawan Hamdan

Publisher: Jordanian Medical services - Jordanian Armed Forces

Main Topics: Medicine

Journal: Journal of the Royal Medical Services 2015 Vol.22 Issue 3, pp.73-76

Document Type: Article

Publication Date: 9/2015

Document Language: English

Document ID (Org No.): 68008

Frequency: Quarterly

eISSN: 20788711

pISSN: 20788703

DOI: 10.12816/0013179

Descriptors:

Issues

Authors:

Maher Mustafa | Al-Jarrah , Omaiema | Nazmi Kamal | Asma Al-Abadi | Ayman Hallosh | Rawan Hamdan

Publisher:

Jordanian Medical services - Jordanian Armed Forces

Main Topics:

Medicine

Journal:

Journal of the Royal Medical Services 2015 Vol.22 Issue 3, pp.73-76

Document Type:

Article

Publication Date:

9/2015

Document Language:

English

Document ID (Org No.):

68008

Frequency:

Quarterly

eISSN:

20788711

pISSN:

20788703

DOI:

10.12816/0013179