Robust Constrained Drug Dosage Regulation of Acute Inflammation Response Under Disturbances

Meric CETİN; Selami BEYHAN

doi:https://doi.org/10.18100/ijamec.815606

Article Details

Robust Constrained Drug Dosage Regulation of Acute Inflammation Response Under Disturbances

Authors:

Meric CETİN | Selami BEYHAN

Publisher:

Selcuk University

Main Topics:

Applied physics

Journal:

International Journal of Applied Mathematics Electronics and Computers 2020 Vol.8 Issue 4, pp.256-262

Document Type:

Article

Publication Date:

12/2020

Document Language:

English

Document ID (Org No.):

2000475744

Frequency:

Quarterly

eISSN:

2147-8228

pISSN:

2147-8228

DOI:

https://doi.org/10.18100/ijamec.815606

Abstract:

 

Mathematical modelling of the biological processes, diseases and organs are important for the model-based control of diseases. Due to unmodeled dynamics, unknown and external disturbances, the performance of controllers based on these models are degraded for the accurate control. Therefore, robust controllers are need especially for the applications on patients. Inflammation, the cause of many complex biological phenomena and diseases, is a nonlinear process that is difficult to control. In this paper, continuous-time sliding-mode controller has been designed for the control of acute inflammation response (AIR) and antibacterial drug infusion under external disturbances both for septic and aseptic cases. Sliding-mode controller (SMC) is mostly used to control nonlinear systems against external disturbances and parametric uncertainties. Beside the control signal generation, we propose constraints on the control signals based on the clinical experiences such that the applied control signal is suitable for the health and improves the performance of the controller. Due to the multiple equilibrium point on the behavior of the acute inflammation response, it is difficult to design such model-based controllers without input constraints. In the numerical applications, septic death case and aseptic death case with disturbances are controlled and acceptable performances are obtained for future clinical applications.

Article Details

Robust Constrained Drug Dosage Regulation of Acute Inflammation Response Under Disturbances

Authors: Meric CETİN | Selami BEYHAN

Publisher: Selcuk University

Main Topics: Applied physics

Journal: International Journal of Applied Mathematics Electronics and Computers 2020 Vol.8 Issue 4, pp.256-262

Document Type: Article

Publication Date: 12/2020

Document Language: English

Document ID (Org No.): 2000475744

Frequency: Quarterly

eISSN: 2147-8228

pISSN: 2147-8228

DOI: https://doi.org/10.18100/ijamec.815606

Issues

Authors:

Meric CETİN | Selami BEYHAN

Publisher:

Selcuk University

Main Topics:

Applied physics

Journal:

International Journal of Applied Mathematics Electronics and Computers 2020 Vol.8 Issue 4, pp.256-262

Document Type:

Article

Publication Date:

12/2020

Document Language:

English

Document ID (Org No.):

2000475744

Frequency:

Quarterly

eISSN:

2147-8228

pISSN:

2147-8228

DOI:

https://doi.org/10.18100/ijamec.815606