S-Aroylmethyl N, N-Disubstituted  Dithiocarbamates With Antiparkinson Activity

Rahime ŞİMŞEK

Article Details

S-Aroylmethyl N, N-Disubstituted Dithiocarbamates With Antiparkinson Activity

Authors:

Rahime ŞİMŞEK

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 6, pp.627-630

Document Type:

Article

Publication Date:

5/1999

Document Language:

Turkish

Document ID (Org No.):

2000757782

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Keywords:

Abstract:

 

Seven S-aroylmethyl N,N-disubstituted dithiocarbamate derivatives have been synthesized and their effects on   oxotremorine induced tremor have been investigated on mice pretreated with the proparkinsonian drug haloperidol. While the compound 1f inhibited oxotremorine-induced tremors at doses of 50 mg/kg and 100 mg/kg levels, compounds 1a, 1c and 1e had this effect at the dose of 100 mg/kg. The compounds 1b, 1d and 1g had no effect on oxotremorine-induced tremors in mice. These results suggest that some of these derivatives have central antimuscarinic effects and antiparkinson activities.

 

Seven S-aroylmethyl N,N-disubstituted dithiocarbamate derivatives have been synthesized and their effects on   oxotremorine induced tremor have been investigated on mice pretreated with the proparkinsonian drug haloperidol. While the compound 1f inhibited oxotremorine-induced tremors at doses of 50 mg/kg and 100 mg/kg levels, compounds 1a, 1c and 1e had this effect at the dose of 100 mg/kg. The compounds 1b, 1d and 1g had no effect on oxotremorine-induced tremors in mice. These results suggest that some of these derivatives have central antimuscarinic effects and antiparkinson activities.

Article Details

S-Aroylmethyl N, N-Disubstituted Dithiocarbamates With Antiparkinson Activity

Authors:

Rahime ŞİMŞEK

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 6, pp.627-630

Document Type:

Article

Publication Date:

5/1999

Document Language:

Turkish

Document ID (Org No.):

2000757782

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Dithiocarbamate

antiparkinson activity

Issues

Article Details

S-Aroylmethyl N, N-Disubstituted Dithiocarbamates With Antiparkinson Activity

Authors: Rahime ŞİMŞEK

Publisher: TUBITAK

Journal: Turkish Journal of Medical Sciences 1999 Vol.29 Issue 6, pp.627-630

Document Type: Article

Publication Date: 5/1999

Document Language: Turkish

Document ID (Org No.): 2000757782

Frequency: Bimonthly

eISSN: 1303-6165

pISSN: 1300-0144

Dithiocarbamate

antiparkinson activity

Issues

Authors:

Rahime ŞİMŞEK

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 6, pp.627-630

Document Type:

Article

Publication Date:

5/1999

Document Language:

Turkish

Document ID (Org No.):

2000757782

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144