Redox Sensing and Cardiac Myocyte Loss: Some Recent Insights

Shyamal K. Goswami

doi:10.3844/ajbbsp.2007.225.232

Article Details

Redox Sensing and Cardiac Myocyte Loss: Some Recent Insights

Authors:

Shyamal K. Goswami

Publisher:

Science Publications

Journal:

American Journal of Biochemistry and Biotechnology Vol.3 Issue 4, pp.225-232

Document Type:

Article

Publication Date:

12/2007

Document Language:

English

Document ID (Org No.):

2001396944

pISSN:

1558-6332

DOI:

10.3844/ajbbsp.2007.225.232

Keywords:

Abstract:

 Generation of reactive oxygen-nitrogen species (ROS/RNS) has long been ascribed to pathophysiological conditions like ageing, neurodegenerative and cardiovascular disorders. However, more recent evidences suggest that while generation of ROS/RNS at a higher threshold is deleterious, at a lower dose these can act as second messengers, influencing specific cellular events like cell growth and differentiation, embryonic development, protection against ischemic injuries and progression of diseases like cancer. With the advent of sophisticated tools of biochemistry and cell biology, it is becoming apparent that various ROS/RNS, when generated transiently at a moderate level, can reversibly modify proteins, causing loss-gain of functions, analogous to that by phosphorylation-dephosphorylation. More significantly, recent studies also suggest that even apoptosis induced by ROS/RNS might also involve discrete cell signaling rather than general surge of ROS/RNS as the dterminant. Taken together, coming days are likely to reveal more discrete nature of ROS/RNS signaling in various cellular contexts including cell death.

Article Details

Redox Sensing and Cardiac Myocyte Loss: Some Recent Insights

Authors:

Shyamal K. Goswami

Publisher:

Science Publications

Journal:

American Journal of Biochemistry and Biotechnology Vol.3 Issue 4, pp.225-232

Document Type:

Article

Publication Date:

12/2007

Document Language:

English

Document ID (Org No.):

2001396944

pISSN:

1558-6332

DOI:

10.3844/ajbbsp.2007.225.232

Reactive oxygen-nitrogen species

Cell signaling

Redox-signaling

Cell survival

Apoptosis

Issues

Article Details

Redox Sensing and Cardiac Myocyte Loss: Some Recent Insights

Authors: Shyamal K. Goswami

Publisher: Science Publications

Journal: American Journal of Biochemistry and Biotechnology Vol.3 Issue 4, pp.225-232

Document Type: Article

Publication Date: 12/2007

Document Language: English

Document ID (Org No.): 2001396944

pISSN: 1558-6332

DOI: 10.3844/ajbbsp.2007.225.232

Reactive oxygen-nitrogen species

Cell signaling

Redox-signaling

Cell survival

Apoptosis

Issues

Authors:

Shyamal K. Goswami

Publisher:

Science Publications

Journal:

American Journal of Biochemistry and Biotechnology Vol.3 Issue 4, pp.225-232

Document Type:

Article

Publication Date:

12/2007

Document Language:

English

Document ID (Org No.):

2001396944

pISSN:

1558-6332

DOI:

10.3844/ajbbsp.2007.225.232