Molecular Targets and Repositioned Drugs For the Treatment of Post  Traumatic Stress Disorder (PTSD)

Elıf Kubat Oktem

Article Details

Molecular Targets and Repositioned Drugs For the Treatment of Post Traumatic Stress Disorder (PTSD)

Authors:

Elıf Kubat Oktem

Publisher:

Afyon Kocatepe University

Main Topics:

Mühendislik

Journal:

Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi Vol.23 Issue 2, pp.532-546

Document Type:

Article

Publication Date:

3/2023

Document Language:

Turkish

Document ID (Org No.):

2001288780

pISSN:

2149-3367

Keywords:

Abstract:

 Post-traumatic stress disorder PTSD is a mental illness caused by trauma following an accident involving physical injury or by mental shock such as anxiety. Although it is common in the population, the prognosis and optimal therapies for PTSD are limited. Because the molecular targets for early intervention remain unclear, a better understanding of the molecular basis of the pathogenesis of PTSD is essential to address the challenges of disease prognosis and to diagnose and treat these molecular targets. In this study, performed by processing and analyzing microarray data from two different tissues of mice exposed to stress, genes with differential expression for the two tissue types were identified, the signaling pathways in which these genes are enriched were found, the protein-protein interaction networks of these genes and the hub proteins in these networks were determined. As a result of comparing the drug repositioning studies performed separately for the two different tissue types to reverse the effects of differentially expressed genes, vorinostat, homoharringtonine, and QL-XII -47 were proposed as novel drugs for the treatment of PTSD. Vorinostat, one of these drugs, was also found to target HDAC1, HDAC2, HDAC3, HDAC6, HDAC7, and HDAC8 genes in the cell.

 Post-traumatic stress disorder PTSD is a mental illness caused by trauma following an accident involving physical injury or by mental shock such as anxiety. Although it is common in the population, the prognosis and optimal therapies for PTSD are limited. Because the molecular targets for early intervention remain unclear, a better understanding of the molecular basis of the pathogenesis of PTSD is essential to address the challenges of disease prognosis and to diagnose and treat these molecular targets. In this study, performed by processing and analyzing microarray data from two different tissues of mice exposed to stress, genes with differential expression for the two tissue types were identified, the signaling pathways in which these genes are enriched were found, the protein-protein interaction networks of these genes and the hub proteins in these networks were determined. As a result of comparing the drug repositioning studies performed separately for the two different tissue types to reverse the effects of differentially expressed genes, vorinostat, homoharringtonine, and QL-XII -47 were proposed as novel drugs for the treatment of PTSD. Vorinostat, one of these drugs, was also found to target HDAC1, HDAC2, HDAC3, HDAC6, HDAC7, and HDAC8 genes in the cell.

 Post-traumatic stress disorder PTSD is a mental illness caused by trauma following an accident involving physical injury or by mental shock such as anxiety. Although it is common in the population, the prognosis and optimal therapies for PTSD are limited. Because the molecular targets for early intervention remain unclear, a better understanding of the molecular basis of the pathogenesis of PTSD is essential to address the challenges of disease prognosis and to diagnose and treat these molecular targets. In this study, performed by processing and analyzing microarray data from two different tissues of mice exposed to stress, genes with differential expression for the two tissue types were identified, the signaling pathways in which these genes are enriched were found, the protein-protein interaction networks of these genes and the hub proteins in these networks were determined. As a result of comparing the drug repositioning studies performed separately for the two different tissue types to reverse the effects of differentially expressed genes, vorinostat, homoharringtonine, and QL-XII -47 were proposed as novel drugs for the treatment of PTSD. Vorinostat, one of these drugs, was also found to target HDAC1, HDAC2, HDAC3, HDAC6, HDAC7, and HDAC8 genes in the cell.

 Travma sonrası stres bozukluğu TSSB, fiziksel hasar veya kaygı gibi zihinsel şok içeren bir kazayı takiben görülen travmanın neden olduğu zihinsel bir hastalıktır. Toplumda yaygın olmasına rağmen, TSSBnin prognozu ve optimal terapötikleri sınırlıdır. Erken müdahale için moleküler hedefler belirsiz kaldığından, daha iyi bir TSSB patogenezinin moleküler temellerinin anlaşılması hastalık prognozunun zorluklarını karşılamak ve bu moleküler hedeflere yönelik teşhis ve tedavi için gereklidir. Strese maruz bırakılan farelerin iki farklı dokusundan elde edilen mikrodizi verilerinin işlenmesi ve analiziyle yapılan bu çalışmada, her iki tip doku için de anlatımı farklılık gösteren genler tespit edilmiş, bu genlerin zenginleştiği yolizleri bulunmuş, bu genlerin protein protein etkileşim ağları ve bu ağlardaki hub proteinler tespit edilmiştir. Bu hastalıkta anlatımı farklılık gösteren genlerin etkilerini tersini çevirmeye yönelik her iki farklı tip doku için de ayrı ayrı yapılan ilaç yeniden konumlandırma çalışmalarının karşılaştırılması sonucunda; vorinostat, homoharringtonin ve QL-XII-47 TSSByi iyileştirmek için yeni ilaç adayları olarak önerilmiştir. Bu ilaçlardan vorinostatın, hücrede HDAC1, HDAC2, HDAC3, HDAC6, HDAC7 ve HDAC8 genlerini hedef aldığı tespit edilmiştir.

Article Details

Molecular Targets and Repositioned Drugs For the Treatment of Post Traumatic Stress Disorder (PTSD)

Authors:

Elıf Kubat Oktem

Publisher:

Afyon Kocatepe University

Main Topics:

Mühendislik

Journal:

Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi Vol.23 Issue 2, pp.532-546

Document Type:

Article

Publication Date:

3/2023

Document Language:

Turkish

Document ID (Org No.):

2001288780

pISSN:

2149-3367

PTSD

systems biology

drug repositioning

BioinformaticsTSSB

Travma sonrası stres bozukluğu

biyoinformatik

ilaç yeniden konumlandırma

sistem biyolojisi

Issues

Article Details

Authors: Elıf Kubat Oktem

Publisher: Afyon Kocatepe University

Main Topics: Mühendislik

Journal: Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi Vol.23 Issue 2, pp.532-546

Document Type: Article

Publication Date: 3/2023

Document Language: Turkish

Document ID (Org No.): 2001288780

pISSN: 2149-3367

Issues

Authors:

Elıf Kubat Oktem

Publisher:

Afyon Kocatepe University

Main Topics:

Mühendislik

Journal:

Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi Vol.23 Issue 2, pp.532-546

Document Type:

Article

Publication Date:

3/2023

Document Language:

Turkish

Document ID (Org No.):

2001288780

pISSN:

2149-3367