Contribution of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) measurements in determining response to treatment in lung cancer

Eser Bulut; Polat Koşucu; Tevfik Ozlu; Muge Kosucu; Halil Kavgacı; İsmet Miraç Çakır; Arzu Coskuner Bulut

Article Details

Contribution of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) measurements in determining response to treatment in lung cancer

Authors:

Eser Bulut | Polat Koşucu | Tevfik Ozlu | Muge Kosucu | Halil Kavgacı | İsmet Miraç Çakır | Arzu Coskuner Bulut

Publisher:

Cukurova University

Main Topics:

Klinik Tıp Bilimleri

Journal:

Cukurova Medical Journal Vol.48 Issue 1, pp.187-193

Document Type:

Article

Publication Date:

3/2023

Document Language:

English

Document ID (Org No.):

2001282241

pISSN:

2602-3032

Keywords:

Abstract:

 Purpose: The purpose of this study was to evaluate the role of diffusion-weighted imaging DWI in evaluating tumor response to chemotherapy in stage III-IV lung cancer. Materials and Methods: Chest and DWI were performed with 3T MRI before and after 3 courses of chemotherapy on 32 patients diagnosed with stage III-IV lung cancer. DWI were acquired with a b factor of 50, 400 and 800 smm using a single-shot echo-planar sequence. Histopathological types before and after chemotherapy were compared by measuring mean apparent diffusion coefficient mADC values on the basis of regression and progression groups. Results: 32 cases, 7 18.5 were in the progression group PG, and 25 81.5 were in the regression group RG. mADC in the PG was 1.060.43 x 10ˉ³ before chemotherapy and 0.850.24 x 10ˉ³ after chemotherapy. mADC in the RG was 0.920.27 x 10ˉ³ before chemotherapy and 1.200.26 x 10ˉ³ after chemotherapy. There was a statistically significant difference between the mADC values in the PG and RG before and after chemotherapy. There was no statistically significant difference in mADC values before and after chemotherapy in small cell lung cancer SCLC tumor type in the PG . There was a statistically significant difference in mADC values before and after chemotherapy in SCLC and non-small cell lung cancer NSCLC tumor types in the RG and NSCLC tumor type in the PG Conclusion: DWI and ADC measurements can be used in assessing response to treatment in malignant pulmonary tumors.

 Purpose: The purpose of this study was to evaluate the role of diffusion-weighted imaging DWI in evaluating tumor response to chemotherapy in stage III-IV lung cancer. Materials and Methods: Chest and DWI were performed with 3T MRI before and after 3 courses of chemotherapy on 32 patients diagnosed with stage III-IV lung cancer. DWI were acquired with a b factor of 50, 400 and 800 smm using a single-shot echo-planar sequence. Histopathological types before and after chemotherapy were compared by measuring mean apparent diffusion coefficient mADC values on the basis of regression and progression groups. Results: 32 cases, 7 18.5 were in the progression group PG, and 25 81.5 were in the regression group RG. mADC in the PG was 1.060.43 x 10ˉ³ before chemotherapy and 0.850.24 x 10ˉ³ after chemotherapy. mADC in the RG was 0.920.27 x 10ˉ³ before chemotherapy and 1.200.26 x 10ˉ³ after chemotherapy. There was a statistically significant difference between the mADC values in the PG and RG before and after chemotherapy. There was no statistically significant difference in mADC values before and after chemotherapy in small cell lung cancer SCLC tumor type in the PG . There was a statistically significant difference in mADC values before and after chemotherapy in SCLC and non-small cell lung cancer NSCLC tumor types in the RG and NSCLC tumor type in the PG Conclusion: DWI and ADC measurements can be used in assessing response to treatment in malignant pulmonary tumors.

 Purpose: The purpose of this study was to evaluate the role of diffusion-weighted imaging DWI in evaluating tumor response to chemotherapy in stage III-IV lung cancer. Materials and Methods: Chest and DWI were performed with 3T MRI before and after 3 courses of chemotherapy on 32 patients diagnosed with stage III-IV lung cancer. DWI were acquired with a b factor of 50, 400 and 800 smm using a single-shot echo-planar sequence. Histopathological types before and after chemotherapy were compared by measuring mean apparent diffusion coefficient mADC values on the basis of regression and progression groups. Results: 32 cases, 7 18.5 were in the progression group PG, and 25 81.5 were in the regression group RG. mADC in the PG was 1.060.43 x 10ˉ³ before chemotherapy and 0.850.24 x 10ˉ³ after chemotherapy. mADC in the RG was 0.920.27 x 10ˉ³ before chemotherapy and 1.200.26 x 10ˉ³ after chemotherapy. There was a statistically significant difference between the mADC values in the PG and RG before and after chemotherapy. There was no statistically significant difference in mADC values before and after chemotherapy in small cell lung cancer SCLC tumor type in the PG . There was a statistically significant difference in mADC values before and after chemotherapy in SCLC and non-small cell lung cancer NSCLC tumor types in the RG and NSCLC tumor type in the PG Conclusion: DWI and ADC measurements can be used in assessing response to treatment in malignant pulmonary tumors.

 Amaç: Bu çalışmada evre III-IV akciğer kanserinde kemoterapiye tümör yanıtının değerlendirilmesinde difüzyon ağırlıklı görüntülemenin DAG rolünü değerlendirmektir. Gereç ve Yöntem: Evre III-IV akciğer kanseri tanılı 32 hastaya 3 kür kemoterapi öncesi ve sonrası 3T MRG ile toraks MRG ve DAG uygulandı. DAG, tek atımlık bir eko-düzlemsel dizi kullanılarak 50, 400 ve 800 smmlik bir b faktörü ile elde edildi. Kemoterapi öncesi ve sonrası histopatolojik tipler, regresyon ve progresyon grupları temelinde ortalama görünür difüzyon katsayısı mADC değerleri ölçülerek istatistiksel olarak karşılaştırıldı. Bulgular: 32 olgudan 7si 18,5 progresyon grubunda PG, 25i 81,5 regresyon grubunda RG yer aldı. PGdeki mADC, kemoterapiden önce 1,060,43 x 10ˉ³ ve kemoterapiden sonra 0,850,24 x 10ˉ³ ölçüldü. RGdeki mADC, kemoterapiden önce 0,920,27 x 10ˉ³ ve kemoterapiden sonra 1,200,26 x 10ˉ³ ölçüldü. Kemoterapi öncesi ve sonrası PG ve RGde mADC değerleri arasında istatistiksel olarak anlamlı fark vardı. PGde küçük hücreli akciğer kanseri KHAK tümör tipinde, kemoterapi öncesi ve sonrası mADC değerlerinde istatistiksel olarak anlamlı fark yoktu. RGde KHAK ve küçük hücreli dışı akciğer kanseri KHDAK tümör tiplerinde ve PGde KHDAK tümör tipinde kemoterapi öncesi ve sonrası mADC değerlerinde istatistiksel olarak anlamlı fark vardı. Sonuç: Malign akciğer tümörlerinde DAG ve ADC ölçümleri tedaviye yanıtı değerlendirmede kullanılabilir.

Article Details

Contribution of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) measurements in determining response to treatment in lung cancer

Authors:

Eser Bulut | Polat Koşucu | Tevfik Ozlu | Muge Kosucu | Halil Kavgacı | İsmet Miraç Çakır | Arzu Coskuner Bulut

Publisher:

Cukurova University

Main Topics:

Klinik Tıp Bilimleri

Journal:

Cukurova Medical Journal Vol.48 Issue 1, pp.187-193

Document Type:

Article

Publication Date:

3/2023

Document Language:

English

Document ID (Org No.):

2001282241

pISSN:

2602-3032

Inoperable lung cancer

treatment response

diffusion-weighted magnetic resonance imaging

İnoperabl akciğer kanseri

tedavi yanıtı

difüzyon ağırlıklı manyetik rezonans görüntüleme

Issues

Article Details

Contribution of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) measurements in determining response to treatment in lung cancer

Authors: Eser Bulut | Polat Koşucu | Tevfik Ozlu | Muge Kosucu | Halil Kavgacı | İsmet Miraç Çakır | Arzu Coskuner Bulut

Publisher: Cukurova University

Main Topics: Klinik Tıp Bilimleri

Journal: Cukurova Medical Journal Vol.48 Issue 1, pp.187-193

Document Type: Article

Publication Date: 3/2023

Document Language: English

Document ID (Org No.): 2001282241

pISSN: 2602-3032

Inoperable lung cancer

treatment response

diffusion-weighted magnetic resonance imaging

İnoperabl akciğer kanseri

tedavi yanıtı

difüzyon ağırlıklı manyetik rezonans görüntüleme

Issues

Authors:

Eser Bulut | Polat Koşucu | Tevfik Ozlu | Muge Kosucu | Halil Kavgacı | İsmet Miraç Çakır | Arzu Coskuner Bulut

Publisher:

Cukurova University

Main Topics:

Klinik Tıp Bilimleri

Journal:

Cukurova Medical Journal Vol.48 Issue 1, pp.187-193

Document Type:

Article

Publication Date:

3/2023

Document Language:

English

Document ID (Org No.):

2001282241

pISSN:

2602-3032