The effects of non-steroid anti-inflammatory drugs on healing of colonic anastomosis in rats

Ersoy ESEN; İlker SUCULLU; Huseyin SİNAN; Zafer KÜÇÜKODACI; Ali İlker FİLİZ; Ergun YUCEL; Mehmet Levhi AKIN

Article Details

The effects of non-steroid anti-inflammatory drugs on healing of colonic anastomosis in rats

Authors:

Ersoy ESEN | İlker SUCULLU | Huseyin SİNAN | Zafer KÜÇÜKODACI | Ali İlker FİLİZ | Ergun YUCEL | Mehmet Levhi AKIN

Publisher:

Van Yuzuncu Yıl University

Journal:

EASTERN JOURNAL OF MEDICINE 2008 Vol.13 Issue 1-2, pp.1-18

Document Type:

Article

Publication Date:

1/2013

Document Language:

English

Document ID (Org No.):

2000773279

Frequency:

Monthly

eISSN:

1301-0883

pISSN:

1301-0883

Abstract:

 


Abstract. NSAIDs have dual roles of providing analgesia and promoting healing.  This study investigated the effects of 3 different NSAIDs on healing of colonic anastomosis in rats.  The aim is to provide an evidence-based rationale for choice of postoperative analgesic agent in surgical patients who undergo this procedure. Forty-eight Sprague-Dawley conventional rats were separated into 4 groups of 12 rats, with one group as control, and the other groups receiving tenoxicam, metamizole, or diclofenac, respectively.  Each group was subdivided into 2 subgroups according to sacrifice on postoperative day 3 or 7. Anastomotic healing was assessed by 3 parameters: (1) physical evaluation (bursting pressure), (2) histological evaluation (fibrotic index), and (3) biochemical evaluation (tissue hydroxyproline levels). Diclofenac had a negative effect on bursting pressures.  Tenoxicam significantly increased the fibrotic index at day 7. Metamizole increased tissue hydroxyproline levels at day 3, but there was no significant difference between control and NSAID groups at day 7. Each drug showed benefits and drawbacks. Because tenoxicam promoted fibrosis, and metamizole increased collagen synthesis, with both agents showing few disadvantages, these 2 agents are recommended above diclofenac for promoting healing.

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Article Details

The effects of non-steroid anti-inflammatory drugs on healing of colonic anastomosis in rats

Authors: Ersoy ESEN | İlker SUCULLU | Huseyin SİNAN | Zafer KÜÇÜKODACI | Ali İlker FİLİZ | Ergun YUCEL | Mehmet Levhi AKIN

Publisher: Van Yuzuncu Yıl University

Journal: EASTERN JOURNAL OF MEDICINE 2008 Vol.13 Issue 1-2, pp.1-18

Document Type: Article

Publication Date: 1/2013

Document Language: English

Document ID (Org No.): 2000773279

Frequency: Monthly

eISSN: 1301-0883

pISSN: 1301-0883

Issues

Authors:

Ersoy ESEN | İlker SUCULLU | Huseyin SİNAN | Zafer KÜÇÜKODACI | Ali İlker FİLİZ | Ergun YUCEL | Mehmet Levhi AKIN

Publisher:

Van Yuzuncu Yıl University

Journal:

EASTERN JOURNAL OF MEDICINE 2008 Vol.13 Issue 1-2, pp.1-18

Document Type:

Article

Publication Date:

1/2013

Document Language:

English

Document ID (Org No.):

2000773279

Frequency:

Monthly

eISSN:

1301-0883

pISSN:

1301-0883