A GREEN AND EFFICIENT METHOD FOR THE SYNTHESIS OF HOMODIMERIC (Β-DICARBONYL) ARYLMETHANES AND DIHYDROPYRIDINE FROM DIMEDONE IN WATER

Bayou-khier N.; Amari M.; Fodili M.; Grau S.g.; Hoffmann P.

Article Details

A GREEN AND EFFICIENT METHOD FOR THE SYNTHESIS OF HOMODIMERIC (Β-DICARBONYL) ARYLMETHANES AND DIHYDROPYRIDINE FROM DIMEDONE IN WATER

Authors:

Bayou-khier N. | Amari M. | Fodili M. | Grau S.g. | Hoffmann P.

Publisher:

Université d'El Oued

Journal:

Revue des Sciences Fondamentales Appliquées Vol.8 Issue 3, pp.945-955

Document Type:

Article

Publication Date:

9/2016

Document Language:

English

Document ID (Org No.):

2001408870

pISSN:

2588-1914

Keywords:

Abstract:

 A direct method has been developed for the synthesis of the dihydropyridine ring system by means of Michael reaction. The reaction of dimedone with 1 .0 equiv. of amines in water provides intermediate product, which allowed dihydropyridine derivatives by intramolecular cyclization in various yields. Of particular interest is the use of the water as solvent of reaction and in absence of catalyst. Also these operating conditions protect the environment and economic points of view.

Article Details

A GREEN AND EFFICIENT METHOD FOR THE SYNTHESIS OF HOMODIMERIC (Β-DICARBONYL) ARYLMETHANES AND DIHYDROPYRIDINE FROM DIMEDONE IN WATER

Authors:

Bayou-khier N. | Amari M. | Fodili M. | Grau S.g. | Hoffmann P.

Publisher:

Université d'El Oued

Journal:

Revue des Sciences Fondamentales Appliquées Vol.8 Issue 3, pp.945-955

Document Type:

Article

Publication Date:

9/2016

Document Language:

English

Document ID (Org No.):

2001408870

pISSN:

2588-1914

aqueous synthesis

bioactivity

dihydropyridine

dimedone

green method

selective conditions

Issues

Article Details

A GREEN AND EFFICIENT METHOD FOR THE SYNTHESIS OF HOMODIMERIC (Β-DICARBONYL) ARYLMETHANES AND DIHYDROPYRIDINE FROM DIMEDONE IN WATER

Authors: Bayou-khier N. | Amari M. | Fodili M. | Grau S.g. | Hoffmann P.

Publisher: Université d'El Oued

Journal: Revue des Sciences Fondamentales Appliquées Vol.8 Issue 3, pp.945-955

Document Type: Article

Publication Date: 9/2016

Document Language: English

Document ID (Org No.): 2001408870

pISSN: 2588-1914

aqueous synthesis

bioactivity

dihydropyridine

dimedone

green method

selective conditions

Issues

Authors:

Bayou-khier N. | Amari M. | Fodili M. | Grau S.g. | Hoffmann P.

Publisher:

Université d'El Oued

Journal:

Revue des Sciences Fondamentales Appliquées Vol.8 Issue 3, pp.945-955

Document Type:

Article

Publication Date:

9/2016

Document Language:

English

Document ID (Org No.):

2001408870

pISSN:

2588-1914