Action of Aspirin on Acetylcholine-Stimulated  Tear Secretion in Rats

Zerrin KAPICIOĞLU

Article Details

Action of Aspirin on Acetylcholine-Stimulated Tear Secretion in Rats

Authors:

Zerrin KAPICIOĞLU

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 6, pp.623-626

Document Type:

Article

Publication Date:

5/1999

Document Language:

Turkish

Document ID (Org No.):

2000757780

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Keywords:

Abstract:

 

In this study we investigated the effect of acetylsalicylic acid (ASA) on tear secretion in rats. The animals were   anesthetized intraperitoneally (ip) with urethane (1,2g/kg). The treatment was injected subcutaneously (s.c.). Tear samples were collected by folding a 5 mm section of a Schirmer strip over the lower lid margin to absorb tear fluid from the lower conjunctival sac for 5 min. Forty animals were divided into four groups (n=10). Group 1 (control) received 1ml of saline, group 2 received 60mg/kg of ASA, group 3 received 50mg/kg of Acetylcholine (Ach), and group 4 received   60mg/kg of ASA and 30 min later 50mg of Ach. While Ach alone significantly increased tear secretion, ASA reduced it when compared to saline (control) (p.

 

In this study we investigated the effect of acetylsalicylic acid (ASA) on tear secretion in rats. The animals were   anesthetized intraperitoneally (ip) with urethane (1,2g/kg). The treatment was injected subcutaneously (s.c.). Tear samples were collected by folding a 5 mm section of a Schirmer strip over the lower lid margin to absorb tear fluid from the lower conjunctival sac for 5 min. Forty animals were divided into four groups (n=10). Group 1 (control) received 1ml of saline, group 2 received 60mg/kg of ASA, group 3 received 50mg/kg of Acetylcholine (Ach), and group 4 received   60mg/kg of ASA and 30 min later 50mg of Ach. While Ach alone significantly increased tear secretion, ASA reduced it when compared to saline (control) (p.

Article Details

Action of Aspirin on Acetylcholine-Stimulated Tear Secretion in Rats

Authors:

Zerrin KAPICIOĞLU

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 6, pp.623-626

Document Type:

Article

Publication Date:

5/1999

Document Language:

Turkish

Document ID (Org No.):

2000757780

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Aspirin

acetylsalicylic acid

acetylcholine

tear secretion

rat.

Issues

Article Details

Action of Aspirin on Acetylcholine-Stimulated Tear Secretion in Rats

Authors: Zerrin KAPICIOĞLU

Publisher: TUBITAK

Journal: Turkish Journal of Medical Sciences 1999 Vol.29 Issue 6, pp.623-626

Document Type: Article

Publication Date: 5/1999

Document Language: Turkish

Document ID (Org No.): 2000757780

Frequency: Bimonthly

eISSN: 1303-6165

pISSN: 1300-0144

Aspirin

acetylsalicylic acid

acetylcholine

tear secretion

rat.

Issues

Authors:

Zerrin KAPICIOĞLU

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 6, pp.623-626

Document Type:

Article

Publication Date:

5/1999

Document Language:

Turkish

Document ID (Org No.):

2000757780

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144