An effective treatment for progressive keratoconus with two-year outcomes: accelerated epithelium-on corneal cross-linking

Muhammet Kaim; Murat Okutucu; Hüseyin Fındık; Feyzahan Uzun

Article Details

An effective treatment for progressive keratoconus with two-year outcomes: accelerated epithelium-on corneal cross-linking

Authors:

Muhammet Kaim | Murat Okutucu | Hüseyin Fındık | Feyzahan Uzun

Publisher:

Pamukkale University

Main Topics:

Göz Hastalıkları

Journal:

Pamukkale Tıp Dergisi Vol.17 Issue 4, pp.764-772

Document Type:

Article

Publication Date:

9/2024

Document Language:

English

Document ID (Org No.):

2001315054

pISSN:

1308-0865

Keywords:

Abstract:

 Purpose: Corneal collagen cross-linking CXL is a surgical technique for progressive keratoconus. There are several technical modifications with varying clinical outcomes. This study aimed to evaluate the long-term outcomes of the accelerated epithelium-on CXL. Materials and methods: A retrospective study was performed on progressive keratoconus patients treated via the accelerated epithelium-on CXL who completed the 24th-month follow-up. We included 111 eyes of 77 patients. Clinical variables, including visual acuity, aberrometry, topographic measurements, and refractive outcomes, were evaluated at the postoperative 12th and 24th months. Results: There was a significant improvement in postoperative visual acuity in 50.4 of patients p0.001. Baiocchi Calossi Versaci total index and lower low-order aberration values determined at the 12th-month and 24th-month follow-up visits were significantly higher than the baseline values p0.044 and p0.033. The depths of the anterior chapter and its aqueous part, the anterior chamber volume, front apical keratometry, and the mean power of the pupil were significantly lower in the 12th and 24th-month evaluations than the baseline values p0.05. For the 12th-month evaluation, significant increments in the central corneal thickness p0.043 and back apical keratometry p0.034 were detected than the baseline values. The horizontal anterior chamber diameter p0.005 and the keratoconus area p0.001 were significantly different in the 24th-month evaluation than in the preoperative period. Conclusion: The study findings indicated that accelerated epithelium-on CXL stabilized disease progression and significantly improved visual acuity. Therefore, accelerated epithelium-on CXL stands out as one of the better options among the modified CXL techniques to treat progressive keratoconus surgically.

 Purpose: Corneal collagen cross-linking CXL is a surgical technique for progressive keratoconus. There are several technical modifications with varying clinical outcomes. This study aimed to evaluate the long-term outcomes of the accelerated epithelium-on CXL. Materials and methods: A retrospective study was performed on progressive keratoconus patients treated via the accelerated epithelium-on CXL who completed the 24th-month follow-up. We included 111 eyes of 77 patients. Clinical variables, including visual acuity, aberrometry, topographic measurements, and refractive outcomes, were evaluated at the postoperative 12th and 24th months. Results: There was a significant improvement in postoperative visual acuity in 50.4 of patients p0.001. Baiocchi Calossi Versaci total index and lower low-order aberration values determined at the 12th-month and 24th-month follow-up visits were significantly higher than the baseline values p0.044 and p0.033. The depths of the anterior chapter and its aqueous part, the anterior chamber volume, front apical keratometry, and the mean power of the pupil were significantly lower in the 12th and 24th-month evaluations than the baseline values p0.05. For the 12th-month evaluation, significant increments in the central corneal thickness p0.043 and back apical keratometry p0.034 were detected than the baseline values. The horizontal anterior chamber diameter p0.005 and the keratoconus area p0.001 were significantly different in the 24th-month evaluation than in the preoperative period. Conclusion: The study findings indicated that accelerated epithelium-on CXL stabilized disease progression and significantly improved visual acuity. Therefore, accelerated epithelium-on CXL stands out as one of the better options among the modified CXL techniques to treat progressive keratoconus surgically.

 Purpose: Corneal collagen cross-linking CXL is a surgical technique for progressive keratoconus. There are several technical modifications with varying clinical outcomes. This study aimed to evaluate the long-term outcomes of the accelerated epithelium-on CXL. Materials and methods: A retrospective study was performed on progressive keratoconus patients treated via the accelerated epithelium-on CXL who completed the 24th-month follow-up. We included 111 eyes of 77 patients. Clinical variables, including visual acuity, aberrometry, topographic measurements, and refractive outcomes, were evaluated at the postoperative 12th and 24th months. Results: There was a significant improvement in postoperative visual acuity in 50.4 of patients p0.001. Baiocchi Calossi Versaci total index and lower low-order aberration values determined at the 12th-month and 24th-month follow-up visits were significantly higher than the baseline values p0.044 and p0.033. The depths of the anterior chapter and its aqueous part, the anterior chamber volume, front apical keratometry, and the mean power of the pupil were significantly lower in the 12th and 24th-month evaluations than the baseline values p0.05. For the 12th-month evaluation, significant increments in the central corneal thickness p0.043 and back apical keratometry p0.034 were detected than the baseline values. The horizontal anterior chamber diameter p0.005 and the keratoconus area p0.001 were significantly different in the 24th-month evaluation than in the preoperative period. Conclusion: The study findings indicated that accelerated epithelium-on CXL stabilized disease progression and significantly improved visual acuity. Therefore, accelerated epithelium-on CXL stands out as one of the better options among the modified CXL techniques to treat progressive keratoconus surgically.

 Amaç: Korneal kollajen çapraz bağlama CXL, progresif keratokonus için cerrahi bir tekniktir. Farklı klinik sonuçlara sahip çeşitli teknik modifikasyonları vardır. Bu çalışmada, hızlandırılmış epitelyum-on CXLnin uzun vadeli sonuçlarını değerlendirmeyi amaçladık. Gereç ve yöntem: Hızlandırılmış epitelyum-on CXL ile tedavi edilen ve 24. ay takibini tamamlayan progresif keratokonus hastaları üzerinde retrospektif bir çalışma yaptık. 77 hastanın 111 gözünü dahil ettik. Görme keskinliği, aberrometri, topografik ölçümler ve kırma kusurları gibi klinik değişkenleri cerrahi sonrası 12. ve 24. aylarda değerlendirdik. Bulgular: Hastaların 50,4ünde ameliyat sonrası görme keskinliğinde anlamlı artış görüldü p0,001. 12. ay ve 24. ay takiplerinde belirlenen Baiocchi Calossi Versaci total indeksi ve alt düşük dereceli aberasyon değerleri, başlangıç değerlerinden anlamlı derecede yüksekti p0,044 ve p0,033. Ön kamara derinliği, ön kamara hacmi, ön apikal keratometri ve gözbebeğinin ortalama gücü, 12. ve 24. ay değerlendirmelerinde başlangıç değerlerine göre anlamlı derecede düşüktü p0,05. 12. ay değerlendirmesinde santral kornea kalınlığında p0,043 ve arka apikal keratometride p0,034 başlangıç değerlerine göre anlamlı artışlar tespit edildi. Horizontal ön kamara çapı p0,005 ve keratokonus alanı p0,001 24. ay değerlendirmesinde ameliyat öncesine göre anlamlı olarak farklıydı. Sonuç: Çalışma bulguları, hızlandırılmış epitelyum-on CXLin görme keskinliğini önemli ölçüde artırdığını ve hastalığın progresyonunu durdurduğunu gösterdi. Böylece, hızlandırılmış epitelyum-on CXLin, progresif keratokonusun cerrahi tedavisinde modifiye CXL yöntemleri arasında iyi bir seçenek olduğu ortaya konuldu.

Article Details

An effective treatment for progressive keratoconus with two-year outcomes: accelerated epithelium-on corneal cross-linking

Authors:

Muhammet Kaim | Murat Okutucu | Hüseyin Fındık | Feyzahan Uzun

Publisher:

Pamukkale University

Main Topics:

Göz Hastalıkları

Journal:

Pamukkale Tıp Dergisi Vol.17 Issue 4, pp.764-772

Document Type:

Article

Publication Date:

9/2024

Document Language:

English

Document ID (Org No.):

2001315054

pISSN:

1308-0865

Aberrometry

corneal topography

epithelium-on corneal cross-linking

keratoconus

visual acuityAberometri

görme keskinliği

Epi-on korneal çapraz bağlama

keratokonus

korneal topografi

Issues

Article Details

Authors: Muhammet Kaim | Murat Okutucu | Hüseyin Fındık | Feyzahan Uzun

Publisher: Pamukkale University

Main Topics: Göz Hastalıkları

Journal: Pamukkale Tıp Dergisi Vol.17 Issue 4, pp.764-772

Document Type: Article

Publication Date: 9/2024

Document Language: English

Document ID (Org No.): 2001315054

pISSN: 1308-0865

Issues

Authors:

Muhammet Kaim | Murat Okutucu | Hüseyin Fındık | Feyzahan Uzun

Publisher:

Pamukkale University

Main Topics:

Göz Hastalıkları

Journal:

Pamukkale Tıp Dergisi Vol.17 Issue 4, pp.764-772

Document Type:

Article

Publication Date:

9/2024

Document Language:

English

Document ID (Org No.):

2001315054

pISSN:

1308-0865