Ischemia Modified Albumin Levels in Infants of Diabetic Mother : Relation to Maternal Glycemic Control

Rania A. El-Farrash; Eman A. Ismail; Ahmed S. Nada; Khaled Y. Hassan

doi:10.12816/0049210

Article Details

Ischemia Modified Albumin Levels in Infants of Diabetic Mother : Relation to Maternal Glycemic Control

Authors:

Rania A. El-Farrash | Eman A. Ismail | Ahmed S. Nada | Khaled Y. Hassan

Publisher:

Ain Shams University : Egyptian Paediatric Society

Main Topics:

Medicine

Journal:

Egyptian Journal of Pediatrics 2017 Vol.34 Issue 1-2, pp.39-47

Document Type:

Article

Publication Date:

6/2017

Document Language:

English

Document ID (Org No.):

123735

Frequency:

Quarterly

pISSN:

16871677

DOI:

10.12816/0049210

Descriptors:

Abstract:

 Background: Ischemia modified albumin (IMA) is an altered type of serum albumin that forms under conditions of oxidative stress. Few studies investigated the role of IMA as a marker of maternal-fetal oxidative stress in diabetic mothers and their infants
Aim: To determine levels of IMA in infants of diabetic mothers and to assess its relation to maternal glycemic control.
Methods: This study was conducted on 100 full term neonates delivered at Obstetrics and gynecology hospital, Ain Shams University; 50 infants were born to diabetic mothers and another 50 age- and sex-matched healthy infants were enrolled as controls. Patients were subjected to detailed medical history and examination focusing on the type of diabetes and its treatment. Maternal laboratory investigations included random blood glucose (RBG) and HbA1c. IMA levels were measured in cord blood.
Results: Upon comparison between diabetic mothers and control group as regards clinical data, it was found that infant of diabetic mothers had higher birth weight than control group and bigger occiptofrontal circumference (p<0.001). IMA levels were higher among infants of diabetic mothers than control group (median 58.5 versus 16 ng/mL; p<0.001). IMA was positively correlated to maternal RBG and HbA1c (p<0.001).
Conclusion: Oxidative stress is enhanced in infants of diabetic mothers as manifested by increased IMA levels. Proper metabolic control among diabetic mothers is mandatory to avoid oxidative stress and its postnatal complications.

Article Details

Ischemia Modified Albumin Levels in Infants of Diabetic Mother : Relation to Maternal Glycemic Control

Authors:

Rania A. El-Farrash | Eman A. Ismail | Ahmed S. Nada | Khaled Y. Hassan

Publisher:

Ain Shams University : Egyptian Paediatric Society

Main Topics:

Medicine

Journal:

Egyptian Journal of Pediatrics 2017 Vol.34 Issue 1-2, pp.39-47

Document Type:

Article

Publication Date:

6/2017

Document Language:

English

Document ID (Org No.):

123735

Frequency:

Quarterly

pISSN:

16871677

DOI:

10.12816/0049210

Descriptors:

ISCHAEMIA

CIRCULATORY DISORDERS

ALBUMINS

NEONATAL DISEASES

PAEDIATRICS

INFANTS

DIABETES

PREGNANCY

Issues

Article Details

Authors: Rania A. El-Farrash | Eman A. Ismail | Ahmed S. Nada | Khaled Y. Hassan

Publisher: Ain Shams University : Egyptian Paediatric Society

Main Topics: Medicine

Journal: Egyptian Journal of Pediatrics 2017 Vol.34 Issue 1-2, pp.39-47

Document Type: Article

Publication Date: 6/2017

Document Language: English

Document ID (Org No.): 123735

Frequency: Quarterly

pISSN: 16871677

DOI: 10.12816/0049210

Descriptors:

Issues

Authors:

Rania A. El-Farrash | Eman A. Ismail | Ahmed S. Nada | Khaled Y. Hassan

Publisher:

Ain Shams University : Egyptian Paediatric Society

Main Topics:

Medicine

Journal:

Egyptian Journal of Pediatrics 2017 Vol.34 Issue 1-2, pp.39-47

Document Type:

Article

Publication Date:

6/2017

Document Language:

English

Document ID (Org No.):

123735

Frequency:

Quarterly

pISSN:

16871677

DOI:

10.12816/0049210