Effects of ethyl pyruvate administration on female rats&#8217; pyramidal cells of cornu ammonis after brain ischemia: a stereological and histopathological study

Ayşe İKİNCİ; Ersan ODACI; Orhan BAŞ

Article Details

Effects of ethyl pyruvate administration on female rats’ pyramidal cells of cornu ammonis after brain ischemia: a stereological and histopathological study

Authors:

Ayşe İKİNCİ | Ersan ODACI | Orhan BAŞ

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2013 Vol.43 Issue 3, pp.354-361

Document Type:

Article

Publication Date:

2/2013

Document Language:

Turkish

Document ID (Org No.):

2000753707

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Keywords:

Abstract:

 

Since ethyl pyruvate (EP) is a known neuroprotective agent, this study was intended to investigate the effects of EP on pyramidal cell numbers and morphology in the hippocampus cornu ammonis after brain ischemia.  Materials and methods: Female rats were divided into 5 groups: control, ischemia, ischemia + EP, incision + EP, and incision + Ringer's lactate (groups I, II, III, IV, and V, respectively). No intervention was performed in group I. Ischemia was established in groups II and III, and neck incisions were performed in groups IV and V. EP was intraperitoneally injected in groups III and IV. Ringer's lactate was also administered to group V. Brains were evaluated stereologically and histopathologically.  Results: The total number of pyramidal cells in group II was significantly lower than those in groups I, IV, and V. The total number of pyramidal cells in group III was significantly lower than those in groups I and IV.   Conclusion: Ischemia reduces the number of pyramidal cells in the cornu ammonis, and EP has no effect on the number of pyramidal cells in the 16-week-old female rat cornu ammonis after brain ischemia.

 

Since ethyl pyruvate (EP) is a known neuroprotective agent, this study was intended to investigate the effects of EP on pyramidal cell numbers and morphology in the hippocampus cornu ammonis after brain ischemia.  Materials and methods: Female rats were divided into 5 groups: control, ischemia, ischemia + EP, incision + EP, and incision + Ringer's lactate (groups I, II, III, IV, and V, respectively). No intervention was performed in group I. Ischemia was established in groups II and III, and neck incisions were performed in groups IV and V. EP was intraperitoneally injected in groups III and IV. Ringer's lactate was also administered to group V. Brains were evaluated stereologically and histopathologically.  Results: The total number of pyramidal cells in group II was significantly lower than those in groups I, IV, and V. The total number of pyramidal cells in group III was significantly lower than those in groups I and IV.   Conclusion: Ischemia reduces the number of pyramidal cells in the cornu ammonis, and EP has no effect on the number of pyramidal cells in the 16-week-old female rat cornu ammonis after brain ischemia.

Article Details

Effects of ethyl pyruvate administration on female rats’ pyramidal cells of cornu ammonis after brain ischemia: a stereological and histopathological study

Authors:

Ayşe İKİNCİ | Ersan ODACI | Orhan BAŞ

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2013 Vol.43 Issue 3, pp.354-361

Document Type:

Article

Publication Date:

2/2013

Document Language:

Turkish

Document ID (Org No.):

2000753707

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Ethyl pyruvate

hippocampus

ischemia

stereology

rat

Issues

Article Details

Effects of ethyl pyruvate administration on female rats&#8217; pyramidal cells of cornu ammonis after brain ischemia: a stereological and histopathological study

Authors: Ayşe İKİNCİ | Ersan ODACI | Orhan BAŞ

Publisher: TUBITAK

Journal: Turkish Journal of Medical Sciences 2013 Vol.43 Issue 3, pp.354-361

Document Type: Article

Publication Date: 2/2013

Document Language: Turkish

Document ID (Org No.): 2000753707

Frequency: Bimonthly

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Ethyl pyruvate

hippocampus

ischemia

stereology

rat

Issues

Effects of ethyl pyruvate administration on female rats’ pyramidal cells of cornu ammonis after brain ischemia: a stereological and histopathological study

Authors:

Ayşe İKİNCİ | Ersan ODACI | Orhan BAŞ

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2013 Vol.43 Issue 3, pp.354-361

Document Type:

Article

Publication Date:

2/2013

Document Language:

Turkish

Document ID (Org No.):

2000753707

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144