Antioxidant, Antimicrobial and Anticancer Activities of the Aspergillin PZ and Terphenyllin Secondary Metabolites: An in vitro Study

Yavuz ERDEN; Suat TEKIN; Kevser BETUL CEYLAN; Cigdem TEKIN; Sevda KIRBAG

doi:https://doi.org/10.35378/gujs.467166

Article Details

Antioxidant, Antimicrobial and Anticancer Activities of the Aspergillin PZ and Terphenyllin Secondary Metabolites: An in vitro Study

Authors:

Yavuz ERDEN | Suat TEKIN | Kevser BETUL CEYLAN | Cigdem TEKIN | Sevda KIRBAG

Publisher:

Gazi University

Main Topics:

Applied physics

Journal:

Gazi University Journal of Science 2019 Vol.32 Issue 3, pp.792-800

Document Type:

Article

Publication Date:

8/2019

Document Language:

English

Document ID (Org No.):

2000427936

eISSN:

2147-1762

DOI:

https://doi.org/10.35378/gujs.467166

Abstract:

 


The importance of secondary metabolites obtained from fungi is increasing day by day in terms of human health. Many physiological and pharmacological effects, mainly antimicrobial, anticancer and antioxidant properties of these compounds have been reported. Aim of this study is to determine the anticancer, antioxidant and antimicrobial effects of aspergillin PZ and terphenyllin compounds, which are isolated from Aspergillus and also subjected to limited number of studies. The antimicrobial activity of aspergillin PZ and terphenyllin compounds was determined by using disc diffusion method using different bacteria. The antioxidant property of the compounds was determined by measuring the level of DPPH free radical scavenging. Cytotoxic activity was determined by experiments on human prostate cancer cell lines (PC3 and LNCaP) and over cancer cell line (A2780). Both compounds showed low antimicrobial activity on test bacteria (approximately 2-3 mm zone). High concentrations of applied compounds showed apparent DPPH free radical scavenging activity, while % scavenging activity was quite low at low concentrations. Both compounds showed significant anticancer activity on cancer cell lines (p <0.05). Our results suggest that these two compounds have important biological properties due to their antioxidant and anticancer activities.


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Article Details

Antioxidant, Antimicrobial and Anticancer Activities of the Aspergillin PZ and Terphenyllin Secondary Metabolites: An in vitro Study

Authors: Yavuz ERDEN | Suat TEKIN | Kevser BETUL CEYLAN | Cigdem TEKIN | Sevda KIRBAG

Publisher: Gazi University

Main Topics: Applied physics

Journal: Gazi University Journal of Science 2019 Vol.32 Issue 3, pp.792-800

Document Type: Article

Publication Date: 8/2019

Document Language: English

Document ID (Org No.): 2000427936

eISSN: 2147-1762

DOI: https://doi.org/10.35378/gujs.467166

Issues

Authors:

Yavuz ERDEN | Suat TEKIN | Kevser BETUL CEYLAN | Cigdem TEKIN | Sevda KIRBAG

Publisher:

Gazi University

Main Topics:

Applied physics

Journal:

Gazi University Journal of Science 2019 Vol.32 Issue 3, pp.792-800

Document Type:

Article

Publication Date:

8/2019

Document Language:

English

Document ID (Org No.):

2000427936

eISSN:

2147-1762

DOI:

https://doi.org/10.35378/gujs.467166